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Oxazolidinone Produkt Beschreibung

Oxazolidinone Struktur
51667-26-6
CAS-Nr.
51667-26-6
Englisch Name:
Oxazolidinone
Synonyma:
Oxazolidinone;(R)-(-)-4-ISOPROPYL-3-PROPIMYL-2-OXAZOLIDINOE
CBNumber:
CB01028254
Summenformel:
C3H5NO2
Molgewicht:
87.0773
MOL-Datei:
Mol file

Oxazolidinone Eigenschaften

Sicherheit

Oxazolidinone Chemische Eigenschaften,Einsatz,Produktion Methoden

Pharmazeutische Anwendungen

The oxazolidinones are a novel class of synthetic antimicrobial agents unrelated to any other antibacterial drug class. They were originally developed as monoamine oxidase inhibitors for treatment of depression, with subsequent recognition of their antimicrobial properties. The first members of the group to emerge exhibited potent activity against Gram-positive organisms, but were not developed for human use owing to toxicity in animal models. In the 1990s two less toxic oxazolidinones were developed: eperezolid, a piperazine derivative, and linezolid, a morpholine derivative. Linezolid exhibited the more favorable pharmacokinetic profile and was subsequently licensed for human use.
Numerous chemical analogs have been screened in a search for compounds with enhanced potency, a broader spectrum of activity or a more favorable side effect profile. Several promising candidates have been described, but linezolid remains the only oxazolidinone currently available.
These drugs are characterized by activity against Gram-positive organisms including methicillin-resistant Staphylococcus aureus, penicillin-resistant pneumococci and vancomycin-resistant enterococci. They are inactive against most Gram-negative species, although some investigational compounds are active against fastidious Gramnegative bacteria including Haemophilus influenzae. They have potentially useful activity against mycobacteria, including multiresistant isolates of Mycobacterium tuberculosis. Resistance among Grampositive organisms remains very uncommon (<0.5%) among clinical isolates.

Oxazolidinone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Oxazolidinone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 4)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
XIANG DING CHEMICAL INTL CO.,LTD --
-- China 4375 63
Shanghai International Pharmaceutical Co., Ltd --
-- ronghua@wzpharm.com China 117 51
ecochem international chemical broker --
-- export@ecochem.dk Europe 6423 66
kemikalieimport --
-- Sales@kemikalieimport.dk Europe 6739 47

  • Oxazolidinone
  • (R)-(-)-4-ISOPROPYL-3-PROPIMYL-2-OXAZOLIDINOE
  • 51667-26-6
  • Oxazolidinone
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