Metacetamol
|
|
|
- CAS-Nr.
- 621-42-1
- Bezeichnung:
- Metacetamol
- Englisch Name:
- 3-ACETAMIDOPHENOL
- Synonyma:
- Nebs;bs479;BS 749;BS 479;Rystal;Metalid;Pyrapap;Pedituss;NSC 3990;metacetamol
- CBNumber:
- CB0108898
- Summenformel:
- C8H9NO2
- Molgewicht:
- 151.16
- MOL-Datei:
- 621-42-1.mol
|
Metacetamol Eigenschaften
- Schmelzpunkt:
- 145-148 °C(lit.)
- Siedepunkt:
- 273.17°C (rough estimate)
- Dichte
- 1.249
- Brechungsindex
- 1.5810 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Löslichkeit
- Chloroform (Slightly), DMSO (Slightly), Methanol
- Aggregatzustand
- Crystals, Crystalline Powder or Needles
- pka
- 9.50±0.10(Predicted)
- Farbe
- Off-white to tan or light gray
- PH
- 6-7 (H2O)(saturated solution)
- BRN
- 907998
- CAS Datenbank
- 621-42-1(CAS DataBase Reference)
- EPA chemische Informationen
- 3'-Hydroxyacetanilide (621-42-1)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi,Xn |
|
|
| R-Sätze: |
36/37/38 |
|
|
| S-Sätze: |
26-36 |
|
|
| RIDADR |
2811 |
|
|
| WGK Germany |
2 |
|
|
| RTECS-Nr. |
AE4100000 |
|
|
| F |
1-8 |
|
|
| Hazard Note |
Irritant |
|
|
| TSCA |
Yes |
|
|
| HazardClass |
6.1(b) |
|
|
| PackingGroup |
III |
|
|
| HS Code |
29242995 |
|
|
| Toxizität |
LD50 intraperitoneal in mouse: 1025mg/kg |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P332+P313 |
Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
|
Metacetamol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
off-white to tan or light grey crystals,
Definition
ChEBI: A derivative of phenol which has an acetamido substituent located meta to the phenolic -OH group. It is a non-toxic regioisomer of paracetamol with analgesic properties, but has never been marketed as a drug.
Allgemeine Beschreibung
Light gray solid.
Air & Water Reaktionen
Water insoluble.
Reaktivität anzeigen
Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Brandgefahr
Flash point data for 3-ACETAMIDOPHENOL are not available. 3-ACETAMIDOPHENOL is probably combustible.
läuterung methode
Recrystallise the phenol from water. The 3,5-dinitrobenzamide complex gives orange-yellow crystals from hot H2O and has m 212o. [Beilstein 13 H 415, 13 I 132, 13 II 213, 13 III 950, 13 IV 977.]
Metacetamol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Metacetamol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 222)Lieferanten
621-42-1(Metacetamol)Verwandte Suche:
- N-(3-HYDROXYPHENYL)ACETAMIDE
- M-HYDROXYACETANILIDE
- 3-(Acetylamino)-1-hydroxybenzene
- 3-(Acetylamino)phenol
- 3’-hydroxy-acetanilid
- 3-Hydroxy-4-trimethylammoniobutanoate3'-hydroxyacetanilide
- Acetamide, N-(3-hydroxyphenyl)-
- Acetanilide, 3'-hydroxy-
- BS 479
- BS 749
- bs479
- m-(Acetylamino)phenol
- metacetamol
- Metalid
- n-(3-hydroxyphenyl)-acetamid
- N-Acetyl-m-Aminophenol
- Nebs
- Pedituss
- Pyrapap
- Rystal
- 3-ACETAMIDOPHENOL
- 3-ACETAMINOPHENOL
- 3'-HYDROXYACETANILIDE
- 3-HYDROXYACETANILIDE
- M-ACETAMIDOPHENOL
- M-ACETAMINOPHENOL
- ACETAMIDOPHENOL-3
- 3-Acetamidophenol;N-Acetyl-m-aminophenol;m-Hydroxyacetanilide;3-Hydroxyacetanilide
- META-HYDROXYACETANILIDE
- N-ACETYL-META-AMINOPHENOL
- 3-ACETAMIDOPHENOL 99+%
- m-Hydroxyacetanilide N-(3-Hydroxyphenyl)acetamide
- N-(3-Hydroxyphenyl)acetamide, tech
- 3-AcetaMidophenol, 99+% 25GR
- N-Acetyl-3-hydroxyaniline
- NSC 3990
- 3'-Hydroxyacetanilide , 98.0%(T)
- 3-Acetamidophenol 97%
- Bosutinib Impurity 10
- Neratinib-001
- Prucalopride Impurity42
- 3'-Hydroxyacetanilide>
- N-(3-hydroxyphenyl)acetamide-d3
- 3'-Hydroxyacetanilide
- 621-42-1
- Building Blocks
- Phenols
- Oxygen Compounds
- Organic Building Blocks
- Aromatic Phenols
- Phenol&Thiophenol&Mercaptan
- Anilines, Amides & Amines
- Phenols
