Bazedoxifene

198481-32-2

CAS-Nr.: 198481-32-2

Englisch Name:: Bazedoxifene

Synonyma:: Tse-424;CS-1993;Batoxifene;Bazedoxifen;Bazedoxifene;Bazedoxifeno;Unii-Q16tt9C5bk;BAZEDOXIFENE BASE;Bazedoxifene [inn];Bazedoxifene free base

CBNumber:: CB01458163

Summenformel:: C30H34N2O3

Molgewicht:: 470.6

MOL-Datei:: 198481-32-2.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 112

Bazedoxifene Eigenschaften

Schmelzpunkt:: 98-102°

Siedepunkt:: 694.4±55.0 °C(Predicted)

Dichte: 1.19

storage temp.: Sealed in dry,Store in freezer, under -20°C

Löslichkeit: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Aggregatzustand: Solid

pka: 10.12±0.15(Predicted)

Farbe: White to Very Dark Beige

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

Bildanzeige (GHS)

Alarmwort

Achtung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H360	Kann die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen.	Fertility (Fruchtbarkeit)	Kategorie 1	Achtung	src="/GHS08.jpg" width="20" height="20" />

Sicherheit

P201	Vor Gebrauch besondere Anweisungen einholen.
P202	Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P281	Vorgeschriebene persönliche Schutzausrüstung verwenden.
P308+P313	BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P405	Unter Verschluss aufbewahren.
P501	Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Bazedoxifene Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

Bazedoxifene, 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol (Viviant), was declared to be “approvable” bythe FDA in 2007 for the prevention of postmenopausalosteoporosis. As of mid-2009, final approval in the UnitedStates is still pending. Bazedoxifene was approved inEurope in 2009 for the treatment of post–menopausalosteoporosis.

Clinical Use

Bazedoxifene is an indole-based SERM that is under investigation for the treatment and prevention of postmenopausal osteoporosis. It also is being evaluated in combination with Premarin (conjugated estrogens). Bazedoxifene displaces 17β-estradiol from estrogen receptors and has excellent binding affinity for the receptor itself. Unlike raloxifene, this agent does not cause hot flashes at the doses required to have a beneficial effect on bone. In addition, it does not cause uterine or mammary gland stimulation.

Enzyminhibitor

This potent and selective estrogen receptor modulator, or SERM (FW = 530.65 g/mol; CAS 198481-33-3; Solubility: 00 mM in DMSO), also named 1-[[4-[2- (hexahydro-1H-azepin-1-yl) ethoxy]phenyl]methyl]-2- (4- hydroxyphenyl) -3-methyl-1H-indol-5-ol, selectivity targets the extrogen receptor ERα (IC50 = 26 nM), with weaker action against ERβ (IC50 = 99 nM), inhibiting 17β-estradiol-induced proliferation of MCF-7 cells. Bazedoxifene represents a promising new treatment for osteoporosis, one with a potential for less uterine and vasomotor effects than selective estrogen receptor modulators now used clinically.

Bazedoxifene Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1H-Indol-5-ol, 1-[[4-(2-aminoethoxy)phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl- 1H-Azepine-2,7-dione, tetrahydro-1-[2-[4-[[5-hydroxy-2-(4-hydroxyphenyl)-3-methyl-1H-indol-1-yl]methyl]phenoxy]ethyl]- 1H-Indol-5-ol, 2-[4-(acetyloxy)phenyl]-3-methyl-, 5-acetate Adipaldehyd 1-[4-(2-AZEPAN-1-YL-ETHOXY)-BENZYL]-5-BENZYLOXY-2-(4-BENZYLOXY-PHENYL)-3-METHYL-1H-INDOLE 2-(4-hydroxyphenyl)-3-Methyl-1H-indol-5-ol 4-[2-(1-AZEPANYL)ETHOXY]BENZYL CHLORIDE HCL Perhydroazepin

Downstream Produkte

Bazedoxifene Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 112)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
ChemExpress	+86-021-58950125	info@chemexpress.com	China	557	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58

198481-32-2()Verwandte Suche:

Flavoxat Baclofen p-[2-(Dimethylamino)ethoxy]benzylamin 1-Ethyl-2-phenyl-1H-indol

1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-indol-5-ol
1-((4-(2-Hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
1H-Indol-5-ol, 1-((4-(2-(hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl-
Bazedoxifene
Bazedoxifene [inn]
Bazedoxifeno
Bazedoxifeno [inn-spanish]
Tse-424
Unii-Q16tt9C5bk
Bazedoxifen
CS-1993
Batoxifene
BAZEDOXIFENE BASE
Bazedoxifene free base
1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphen...
1-(4-(2-(Azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
198481-32-2
C30H34N2O3
Aromatics
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals