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Methyl-4-hydroxybenzoat Produkt Beschreibung

Methylparaben Struktur
99-76-3
CAS-Nr.
99-76-3
Bezeichnung:
Methyl-4-hydroxybenzoat
Englisch Name:
Methylparaben
Synonyma:
Abiol;Moldex;Septos;metaben;NIPAGIN;Nigagin;Paraben;Paridol;Solbrol;methaben
CBNumber:
CB0184566
Summenformel:
C8H8O3
Molgewicht:
152.15
MOL-Datei:
99-76-3.mol

Methyl-4-hydroxybenzoat Eigenschaften

Schmelzpunkt:
125-128 °C(lit.)
Siedepunkt:
298.6 °C
Dichte
1,46g/cm
Dampfdruck
0.000005 hPa (20 °C)
FEMA 
2710 | METHYL P-HYDROXYBENZOATE
Brechungsindex
1.4447 (estimate)
Flammpunkt:
280°C
storage temp. 
0-6°C
Löslichkeit
ethanol: soluble0.1M, clear, colorless
pka
pKa 8.15(H2O,t =20.0) (Uncertain)
Aggregatzustand
Crystalline Powder
Farbe
White to almost white
PH
5.8 (H2O, 20°C) (saturated solution)
Wasserlöslichkeit
Slightly soluble in water.
FreezingPoint 
131℃
Merck 
14,6107
BRN 
509801
Stabilität:
Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey
LXCFILQKKLGQFO-UHFFFAOYSA-N
CAS Datenbank
99-76-3(CAS DataBase Reference)
NIST chemische Informationen
Benzoic acid, 4-hydroxy-, methyl ester(99-76-3)
EPA chemische Informationen
Benzoic acid, 4-hydroxy-, methyl ester(99-76-3)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi,Xn
R-Sätze: 36/37/38-20/21/22-36
S-Sätze: 26-36-24/25-39
RIDADR  UN 2769
WGK Germany  1
RTECS-Nr. DH2450000
Selbstentzündungstemperatur >600 °C
TSCA  Yes
HS Code  29182930
Giftige Stoffe Daten 99-76-3(Hazardous Substances Data)
Toxizität LD50 orally in Rabbit: 2100 mg/kg
Bildanzeige (GHS)
Alarmwort
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H412 Schädlich für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 3 P273, P501
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.

Methyl-4-hydroxybenzoat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

Colorless crystals or white, crystallinepowder; odorless or faint characteristic odor; slightburning taste. Soluble in alcohol,ether; slightly soluble in water, benzene, and carbontetrachloride.

Chemische Eigenschaften

Methylparaben occurs as colorless crystals or a white crystalline powder. It is odorless or almost odorless and has a slight burning taste.

Chemische Eigenschaften

Methyl p-hydroxybenzoate is odorless or has a faint characteristic odor and a slight burning taste. Methyl p-hydroxybenzoate is more commonly known as methyl paraben and is an ester of p-hydroxybenzoic acid.

Occurrence

Reported present in cloudberry, yellow passion fruit juice, white wine, botrytised wine and Bourbon vanilla.

Verwenden

parabens is one of the most commonly used group of preservatives in the cosmetic, pharmaceutical, and food industries. Parabens provide bacteriostatic and fungistatic activity against a diverse number of organisms, and are considered safe for use in cosmetics, particularly in light of their low sensitizing potential. An evaluation of preservatives for use in leave-on cosmetic preparations lists parabens among the least sensitizing. The range of concentrations used in cosmetics varies between 0.03 and 0.30 percent, depending on the conditions for use and the product to which the paraben is added.

Verwenden

Methylparaben is an antimicrobial agent which is a white free-flowing powder. it is active against yeast and molds over a wide ph range. see parabens.

Verwenden

It is used as preservative in foods, beverages and cosmetics.

Verwenden

As preservative in foods, beverages and cosmetics.

Definition

ChEBI: A 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. It is the most frequently used antimicrobial preservative in cosmetics. It occurs naturally in several fruits, particularly in blu berries.

Vorbereitung Methode

Methylparaben is prepared by the esterification of p-hydroxybenzoic acid with methanol.

synthetische

Produced by the methanol esterification of p-hydroxybenzoic acid in the presence of sulfuric acid. The materials are heated for distillation in a glass-lined reactor under reflux. The acid is then neutralized with caustic soda and the product is crystallized by cooling. The crystallized product is centrifuged, washed, dried under vacuum, milled and blended, all in corrosion-resistant equipment to avoid metallic contamination.

Aroma threshold values

Detection: 2.6 ppm.

Hazard

Toxic. Use in foods restricted to 0.1%.

Pharmazeutische Anwendungen

Methylparaben is widely used as an antimicrobial preservative in cosmetics, food products, and pharmaceutical formulations; see Table I. It may be used either alone or in combination with other methylparaben is the most frequently used antimicrobial preservative.
The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds. Antimicrobial activity increases as the chain length of the alkyl moiety is increased, but aqueous solubility decreases; therefore a mixture of parabens is frequently used to provide effective preservation. Preservative efficacy is also improved by the addition of propylene glycol (2–5%), or by using parabens in combination with other antimicrobial agents such as imidurea;
Owing to the poor solubility of the parabens, paraben salts (particularly the sodium salt) are more frequently used in formulations. However, this raises the pH of poorly buffered formulations.
Methylparaben (0.18%) together with propylparaben (0.02%) has been used for the preservation of various parenteral pharmaceutical formulations;

Kontakt-Allergie

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

Sicherheit(Safety)

Methylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics and oral and topical pharmaceutical formulations. Although parabens have also been used as preservatives in injections and ophthalmic preparations, they are now generally regarded as being unsuitable for these types of formulations owing to the irritant potential of the parabens. These experiences may depend on immune responses to enzymatically formed metabolites of the parabens in the skin.
Parabens are nonmutagenic, nonteratogenic, and noncarcinogenic. Sensitization to the parabens is rare, and these compounds do not exhibit significant levels of photocontact sensitization or phototoxicity.
Hypersensitivity reactions to parabens, generally of the delayed type and appearing as contact dermatitis, have been reported. However, given the widespread use of parabens as preservatives, such reactions are relatively uncommon; the classification of overstated. Immediate hypersensitivity reactions following injection of preparations containing parabens have also been reported.
Delayed-contact dermatitis occurs more frequently when parabens are used topically, but has also been reported to occur after oral administration.
Unexpectedly, preparations containing parabens may be used by patients who have reacted previously with contact dermatitis provided they are applied to another, unaffected, site. This has been termed the paraben paradox.
Concern has been expressed over the use of methylparaben in infant parenteral products because bilirubin binding may be affected, which is potentially hazardous in hyperbilirubinemic neonates.
The WHO has set an estimated total acceptable daily intake for methyl-, ethyl-, and propylparabens at up to 10 mg/kg bodyweight.
LD50 (dog, oral): 3.0 g/kg
LD50 (mouse, IP): 0.96 g/kg
LD50 (mouse, SC): 1.20 g/kg

Lager

Aqueous solutions of methylparaben at pH 3–6 may be sterilized by autoclaving at 120°C for 20 minutes, without decomposition. Aqueous solutions at pH 3–6 are stable (less than 10% decomposition) for up to about 4 years at room temperature, while aqueous solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days storage at room temperature);
Methylparaben should be stored in a well-closed container in a cool, dry place.

läuterung methode

Fractionally crystallise the ester from its melt, and recrystallise it from *benzene, then from *benzene/MeOH and dry it over CaCl2 in a vacuum desiccator. [Beilstein 10 IV 360.]

Inkompatibilitäten

The antimicrobial activity of methylparaben and other parabens is considerably reduced in the presence of nonionic surfactants, such as polysorbate 80, as a result of micellization.However, propylene glycol (10%) has been shown to potentiate the antimicrobial activity of the parabens in the presence of nonionic surfactants and prevents the interaction between methylparaben and polysorbate 80.
Incompatibilities with other substances, such as bentonite, magnesium trisilicate,talc,tragacanth,sodium alginate, essential oils,sorbitol,and atropine,have been reported. It also reacts with various sugars and related sugar alcohols. Absorption of methylparaben by plastics has also been reported; the amount absorbed is dependent upon the type of plastic and the vehicle. It has been claimed that low-density and high-density polyethylene bottles do not absorb methylparaben.
Methylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.

Regulatory Status

Methylparaben and propylparaben are affirmed GRAS Direct Food Substances in the USA at levels up to 0.1%. All esters except the benzyl ester are allowed for injection in Japan. In cosmetics, the EU and Brazil allow use of each paraben at 0.4%, but the total of all parabens may not exceed 0.8%. The upper limit in Japan is 1.0%.
Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM, IV, and SC injections; inhalation preparations; ophthalmic preparations; oral capsules, tablets, solutions and suspensions; otic, rectal, topical, and vaginal preparations). Included in medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Methyl-4-hydroxybenzoat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Methyl-4-hydroxybenzoat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 490)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 sales@zhonglanindustry.com CHINA 207 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21671 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 535 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-89880739
022-66880086 sales@tjzxchem.com CHINA 575 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2368 58

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