AMASTATIN HYDROCHLORIDE
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- CAS-Nr.
- 100938-10-1
- Englisch Name:
- AMASTATIN HYDROCHLORIDE
- Synonyma:
- AMASTATIN;AMASTATIN HCL;AMASTATIN HYDROCHLORIDE;AMASTATIN HYDROCHLORIDE HYDRATE;H-(2S,3R)-AHMH-VAL-VAL-ASP-OH HCL;Amastatin hydrate hydrochloride;4-formylphenyl-O-β-d-allopyranoside;N((2S 3R)3-AMINO-2-HXY-5-ME.HEXANOYL)-L&;Amastatinhydrochloridebiochemikasynthetic;(2S,3R)-[3-AMINO-2-HYDROXY-5-METHYLHEXANOYL]-VAL-VAL-ASP-OH HCL
- CBNumber:
- CB0194817
- Summenformel:
- C21H39ClN4O8
- Molgewicht:
- 511.01
- MOL-Datei:
- 100938-10-1.mol
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AMASTATIN HYDROCHLORIDE Eigenschaften
- Schmelzpunkt:
- 202-205 °C
- storage temp.
- -20°C
- Löslichkeit
- methanol: 5 mg/mL, clear, colorless
- Aggregatzustand
- White to off-white powder.
- Farbe
- White to off-white
- BRN
- 8888370
AMASTATIN HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Amastatin is a slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of human serum AP-A (glutamyl AP; IC50 = 0.54 μg/ml) but not of AP-B (arginine AP). It also inhibits AP-N (AP-M, alanyl AP; Ki = 20-200 nM), leucyl-cystinyl AP (Ki = 20-220 nM), and endoplasmic reticulum AP 1 (Ki = 41.8 μM). Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin, or thermolysin.[Cayman Chemical]
Allgemeine Beschreibung
Chemical structure: peptide
Biochem/physiol Actions
It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.Effective concentration: 1-10 μM.
AMASTATIN HYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
AMASTATIN HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 97)Lieferanten
100938-10-1()Verwandte Suche:
- [(2S,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOYL]-VAL-VAL-ASP HYDROCHLORIDE
- (2S,3R)-[3-AMINO-2-HYDROXY-5-METHYLHEXANOYL]-VAL-VAL-ASP-OH HCL
- AMASTATIN HYDROCHLORIDE
- AMASTATIN HYDROCHLORIDE HYDRATE
- H-(2S,3R)-AHMH-VAL-VAL-ASP-OH HCL
- N((2S 3R)3-AMINO-2-HXY-5-ME.HEXANOYL)-L&
- Amastatinhydrochloridebiochemikasynthetic
- (2s,3r)-3-amino-2-hydroxy-5-methylhexanoyl-val-val-asp hydrochloride hydrate
- (Amino-2-hydroxy-5-methyl-hexanoyl)-L-valyl-L-valyl-L-aspartic acid hydrochloride salt
- (2S,3R)-3-Amino-2-hydroxy-5-methylhexanoyl-Val-Val-Asp hydrate hydrochloride
- Amastatin hydrate hydrochloride
- L-Aspartic acid,N-[(2S,3R)-3-amino-2-hydroxy-5-methyl-1-oxohexyl]-L-valyl-L-valyl-,monohydrochloride (9CI)
- 4-formylphenyl-O-β-d-allopyranoside
- AMASTATIN HCL
- AMASTATIN
- 100938-10-1
- C21H38N4O8HCl
- C21H38N4O8HClxH2O
- C21H38N4O8ClH
- BioChemical
- Antibiotics
- Antibiotics A to Z
- Antibiotics A-F
- peptides
- inhibitor
- Pepetides
