1,1'-Carbonylbis-1H-imidazol

1,1'-Carbonylbis-1H-imidazol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R34:Verursacht Verätzungen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.

Chemische Eigenschaften

The substance appears as a white to slightly pale-yellow crystalline powder with a melting point range of 115.5-116°C. It exhibits poor solubility in water, while displaying solubility in alcohol and ether.

Verwenden

CDI, also known as 1,1'-carbonyldiimidazole, is a commonly used peptide coupling reagent in the synthesis of peptides and nucleoside triphosphates. It usually contains approximately 10% imidazole and reacts rapidly with carboxylic acids to produce acyl imidazoles. Later, it readily reacts with amines to create amides. In addition, CDI is useful in converting alcohols and amines into a range of chemical compounds, including carbamates, esters, and ureas.

Application

Peptide coupling reagent1,1'-Carbonyldiimidazole acts as a coupling reagent and utilized for coupling of amino acids in order to prepare peptide in organic synthesis. It is also used in the preparation of beta-keto sulfones, sulfoxides and beta-enamino acid derivatives. It is used to convert alcohols and amines into carbamates, esters, and ureas. It is involved in the preparation of formylized imidazole by reaction with formic acid. Further, it is used in the synthesis of dipolar polyamides compounds. In addition to this, it is considered as an equivalent of phosgene and used to prepare asymmetric bis alkyl carbonate.

synthetische

1,1'-Carbonyldiimidazole has been prepared by the reaction of imidazole and phosgene in anhydrous benzene and anhydrous tetrahydrofuran. It has also been obtained by the reaction of 1-(trimethylsilyl)imidazole and phosgene in anhydrous benzene, but that method offers no advantages that justify the more extensive preparative effort required.
DOI: 10.15227/orgsyn.048.0044

Allgemeine Beschreibung

1,1′-Carbonyldiimidazole (N,N′-carbonyldiimidazole) is a versatile peptide-forming reagent.

läuterung methode

Crystallise it from *benzene or tetrahydrofuran in a dry-box and store it dry. [Hearn Methods Enzymol 135 102 1987, Beilstein 23/4 V 245.]

1,1'-Carbonylbis-1H-imidazol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

1,1'-Carbonylbis-1H-imidazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Suzhou Highfine Biotech Co., Ltd	0512-69209928 18796809688	zhouyingxiang@highfine.com	China	472	75
Nantong Xiaochang Pharmaceutical Trading Co., Ltd.	0513-82104991 18862997351	sales11@btcpharm.com	China	861	58
Jinan Dexinjia Bio&Tech Co., Ltd	0531-82375818 15064153060	1329217348@qq.com	China	1447	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 13913916777	cfzhang@aikonchem.com	China	19902	55
Jiangsu zhenri Chemical Co., Ltd	0510-85686299,0510-85686399 400-628-6299	2458891188@qq.com	China	23	58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	13396369453 18678026865	sdfantai@163.com	China	904	58
Changzhou Success Chemical Co., Ltd.	18961148122; 18961148122	278954761@qq.com	China	34	58
Nanjing Labmediate Co., Ltd.	18913390967	tonywu@chemdiate.com	China	18	58
Jiangxi JinKai Chemical Co.,Ltd	15376072011	sales3@dyckbiotech.com	China	15	58
Qingdao Haizhi Weiyuan Biotechnology Co., Ltd.	18317699790 18317699790	l202008112023@163.com	China	7733	58

530-62-1(1,1'-Carbonylbis-1H-imidazol)Verwandte Suche:

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• LABOTEST-BB LT00233203
• IM2 C O
• (DIIMIDAZOL-1-YL)KETONE
• AKOS BBS-00004316
• RARECHEM AK HZ 0060
• 1.1'-CARBONYL-BIS-IMIDAZOLE
• 1H-IMIDAZOLE, 1,1'-CARBONYLBIS-
• 1,1’-carbonylbis-1h-imidazol
• 1,1’-Carbonyldiimidazol
• 1,1'-Carbonylbis-1H-imidazole [Coupling Agent for Peptides Synthesis]
• 1,1'-Carbonyldiimidazole [Coupling Agent for Peptides Synthesis]
• Bis(1H-imidazol-1-yl) ketone
• Bis(1-imidazolyl) ketone
• carbonyl-1,1’-bis-1H-diimidazole
• 1,1'-Carbonyldiimidazole,97%
• 1’-Carbonyldiimidazole
• 1,1'-Carbonyldiimida
• 1,1'-CarbonyldiiMidazole, >90%
• N'-CarbonyldiiMidazole (CDI)
• Product 2: N,N'-CarbonyldiiMidazole
• N,Nzzhlxy-Carbonyldiimidazole (CDI)
• CDI (Carbonyl Diimidazole)
• CARBONYLDIIMIDAZOLE N,N
• CDI (N,N'-Carbonyldiimidazole)
• 1,1-Carbonyldiimidazole99%
• N,N'-Carbonyldiimidazole, 98%+
• N,N'-Carbonyl diimidazole (CDI)
• N,N'-Carbonyldiimidazole,97%
• N,N'-CARBONYL-BIS-(IMIDAZOLE)
• N,NCARBONYLDIIMIDAZOLE,HIGHPURITY
• N,N'-Carbonyldiimidazole 98%
• 1,1''-CARBONYLDIIMIDZOLE
• CDI 1,1''-CARBONYLDIIMIDAZOLE
• N.N''-CARBONYL DICMIDAZOLE
• 1H-Imidazole,1,1-carbonylbis-(9CI)
• Bis(iMidazol-1-yl) Ketone
• Bis(iMidazol-1-yl)Methanone
• NSC 67203
• 1,1'-Carbonylbis-1H-imidazole CDI
• 1,1'-CarbonyldiiMdazole
• 1,1''-CARBONYLDIIMIDAZOLE FOR SYNTHESIS
• CarbonyldiiMaidiazole
• n,ni-carbonyldiimidazole
• CDI >=97.0% (T)
• CDI reagent grade
• 1,1′-Carbonyldiimidazole solution
• CDI Vetec(TM) reagent grade, 97%
• Methanone, di-1H-imidazol-1-yl-
• N,N-Carbonyldiimidazole≥ 98% (Titration)
• N,N-Carbonyldiimidazole Manufacturer
• 97.0%(W)
• 1,1'-Carbonyldiimidazole [Coupling Agent for Peptides Synthesis]>
• 1,1'-Carbonyldiimidazole, >
• CDI 1,1'-Carbonyldiimidazole,98%
• 1,1'-CarbonyL
• e (CDI)
• China CARBONYLDIIMIDAZOLE
• 1,1'-Carbonyldiimidazole USP/EP/BP