4-(Hydroxyamino)-4-oxobutanoic acid
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- CAS-Nr.
- 4743-99-1
- Englisch Name:
- 4-(Hydroxyamino)-4-oxobutanoic acid
- Synonyma:
- Tofacitinib Impurity 208;N-Hydroxysuccinamidic acid;4-(Hydroxyamino)-4-oxobutanoic acid;Butanoic acid, 4-(hydroxyamino)-4-oxo-;3-(Hydroxyaminocarbonyl)propionic acid
- CBNumber:
- CB02174169
- Summenformel:
- C4H7NO4
- Molgewicht:
- 133.1
- MOL-Datei:
- 4743-99-1.mol
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4-(Hydroxyamino)-4-oxobutanoic acid Eigenschaften
- Schmelzpunkt:
- 82-86 °C(Solv: acetonitrile (75-05-8))
- Dichte
- 1.436±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 5.28±0.10(Predicted)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
4-(Hydroxyamino)-4-oxobutanoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
synthetische
To a refluxing solution of 5.0 gm (0.05 mole) of succinic anhydride in 100 ml of benzene is added a solution of 6.3 gm (0.05 mole) of O-ben- zylhydroxylamine in 20 ml of benzene. As soon as the addition has been completed, the reaction mixture is cooled, and the precipitated product is separated. Upon recrystallization from a benzene-methyl ethyl ketone mixture, 7.6 gm (68.2%) of N-benzyloxysuccinamic acid, m.p. 95-96°C isolated.
A suspension of 4.3 gm (0.0193 mole) of this intermediate and a stron- tium carbonate catalyst containing 5% palladium in methyl ethyl ketone is hydrogenated. Upon working up the reaction mixture, 1.45 gm (56.7%) of succinomonohydroxamic acid, m.p. 95-96°C is isolated.
4-(Hydroxyamino)-4-oxobutanoic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-(Hydroxyamino)-4-oxobutanoic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 18)Lieferanten
4743-99-1()Verwandte Suche:
- 3-(Hydroxyaminocarbonyl)propionic acid
- 4-(Hydroxyamino)-4-oxobutanoic acid
- N-Hydroxysuccinamidic acid
- Butanoic acid, 4-(hydroxyamino)-4-oxo-
- Tofacitinib Impurity 208
- 4743-99-1
