N-OXALYL GLYCINE
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- CAS-Nr.
- 5262-39-5
- Englisch Name:
- N-OXALYL GLYCINE
- Synonyma:
- NOG;SYM1;SYNS1;N-OXALYL GLYINE;N-OXALYL GLYCINE;Mouse bearing tumor;N-Oxalylglycine (NOG);In vivo drug screening;Tumor modeling services;Human NOG Protein, Fc Tag
- CBNumber:
- CB0250467
- Summenformel:
- C4H5NO5
- Molgewicht:
- 147.09
- MOL-Datei:
- 5262-39-5.mol
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N-OXALYL GLYCINE Eigenschaften
- Dichte
- 1.638±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- deionized water: >10mg/mL
- Aggregatzustand
- solid
- pka
- 2.83±0.20(Predicted)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi,Xn |
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| R-Sätze: |
22 |
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| WGK Germany |
3 |
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| HazardClass |
IRRITANT |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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N-OXALYL GLYCINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
The jumonji domain-containing protein 2 (JMJD2) subfamily of histone demethylases have been shown to catalyze demethylation of the methylated forms of histone 3 lysine 9 (H3K9) and H3K36 in vitro and in cells. Because histone demethylases are implicated in certain diseases, including cancer, selective inhibitors are candidate anticancer agents as well as potential tools for elucidating the biological functions of JMJDs. N-Oxalylglycine, the amide analog of α-ketoglutarate, is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E (IC50s = 250, 500, and 24 μM, respectively). It can also inhibit the prolyl hydroxylase domain-containing proteins PHD1 and PHD2 with IC50 values of 2.1 and 5.6 μM, respectively.[Cayman Chemical]
Definition
ChEBI: An amino dicarboxylic acid that is iminodiacetic acid with an oxo substituent. It is used as an inhibitor of alpha-ketoglutarate dependent (EC 1.14.11.*) enzymes.
Biochem/physiol Actions
N-Oxalylglycine is an inhibitor of α-ketoglutarate-dependent enzymes and mimics the initial steps but does not initiate the hydroxylation process. N-Oxalylglycine has been used to inhibit Jumonji C-domain-containing histone lysine demethylases.
N-OXALYL GLYCINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-OXALYL GLYCINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 87)Lieferanten
- N-OXALYL GLYINE
- 2-((Carboxymethyl)amino)-2-oxoacetic acid
- SYM1
- SYNS1
- N-OXALYL GLYCINE
- NOG
- Glycine,N-(carboxycarbonyl)-
- Human NOG Protein, His Tag
- Human NOG Protein, Fc Tag
- N-OXALYL GLYCINE USP/EP/BP
- N-Oxalylglycine (NOG)
- N Oxalylglycine,NOxalylglycine
- Tumor modeling services
- In vivo drug screening
- Mouse bearing tumor
- 5262-39-5
- C4H5NO5
- Bio-material
- NONE
- Other
