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2'-(beta-D-Glucopyranosyloxy)-4,'6'-dihydroxy-3-(4-hydroxyphe-nyl)propiophenon Produkt Beschreibung

Phlorizin Struktur
60-81-1
CAS-Nr.
60-81-1
Bezeichnung:
2'-(beta-D-Glucopyranosyloxy)-4,'6'-dihydroxy-3-(4-hydroxyphe-nyl)propiophenon
Englisch Name:
Phlorizin
Synonyma:
NSC 2833;Floridzin;PHLORIZIN;Phlorinin;phlorhizin;phlorizine;PHLORIDZIN;phloridzine;phlorrhizin;Phlorrhizen
CBNumber:
CB0331801
Summenformel:
C21H24O10
Molgewicht:
436.41
MOL-Datei:
60-81-1.mol

2'-(beta-D-Glucopyranosyloxy)-4,'6'-dihydroxy-3-(4-hydroxyphe-nyl)propiophenon Eigenschaften

Schmelzpunkt:
113-114 °C(lit.)
Siedepunkt:
468.89°C (rough estimate)
Dichte
1.3178 (rough estimate)
Brechungsindex
-54 ° (C=3.2, 95% EtOH)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
7.15±0.40(Predicted)
Merck 
14,7327
CAS Datenbank
60-81-1(CAS DataBase Reference)
EPA chemische Informationen
Phlorizin (60-81-1)

Sicherheit

Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26-36
WGK Germany  3
RTECS-Nr. UC2080000
3-10-23
HS Code  29389090

2'-(beta-D-Glucopyranosyloxy)-4,'6'-dihydroxy-3-(4-hydroxyphe-nyl)propiophenon Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

Light Yellow Powder

Verwenden

It is a dihydrochalcone occurring in all parts of the apple tree except the mature fruit. Once thought to occur in pear, plum, cherry trees and other Rosaceae

Verwenden

induces experimental glucosuria, antifeedant

Verwenden

Sodium-glucose cotransporter 1 (SGLT1) is a high affinity, low capacity transporter abundant in the small intestine, with some expression in the kidney as well. SGLT2 is a low affinity, high capacity transporter in the kidney that accounts for approximately 90% of glucose reabsorption into the blood stream. Selective inhibition of SGLT2 is a potential strategy for reducing plasma glucose levels as a treatment for diabetes. Phlorizin is a natural product, first isolated from the bark of apple trees, that reduces plasma glucose levels by blocking renal and intestinal glucose absorption through inhibition of SGLT1 and SGLT2. It competitively inhibits the initial rate of a-methyl-D-glucopyranoside (a-MDG) uptake in human COS-1 cells expressing hSGLT1 and hSGLT2 with IC50 values of 400 and 65 nM, respectively. In HEK293T cells expressing human SGLT1 and SGLT2, phlorizin exhibits Ki values of 140 and 11 nM, respectively, at 37°C.

Definition

ChEBI: An aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 2' via a glycosidic linkage.

läuterung methode

-D-glucoside] [60-81-1] M 472.5, m 110o, [] 20 -62o (c 3.2, EtOH). Phlorizin crystallises as the dihydrate from water and causes glycosuria. [Brazy & Dennis Am J Physiol 234 1279 1978, Zemplen & Bognár Chem Ber 17B 1040 1943, Beilstein 17/7 V 177.]

2'-(beta-D-Glucopyranosyloxy)-4,'6'-dihydroxy-3-(4-hydroxyphe-nyl)propiophenon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2'-(beta-D-Glucopyranosyloxy)-4,'6'-dihydroxy-3-(4-hydroxyphe-nyl)propiophenon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 235)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13815430202 0086 13815430202
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+86-571-56059825 fandachem@gmail.com CHINA 8882 55
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027-59599243 linda@hubeijusheng.com CHINA 28229 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
BOC Sciences
1-631-485-4226
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60-81-1(2'-(beta-D-Glucopyranosyloxy)-4,'6'-dihydroxy-3-(4-hydroxyphe-nyl)propiophenon)Verwandte Suche:


  • 1-propanone,1-(2-(beta-d-glucopyranosyloxy)-4,6-dihydroxyphenyl)-3-(4-hydroxyp
  • phlorhizin
  • phloridzine
  • phlorizine
  • phlorizoside
  • 1-Propanone, 1-[2-(β-D-glucopyranosyloxy)-
  • 4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-
  • Floridzin
  • 1-(2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)-propan-1-on
  • phlorrhizin
  • TIMTEC-BB SBB005924
  • PHLORIZIN HYDRATE
  • PHLORETIN-2'-BETA-D-GLUCOPYRANOSIDE DIHYDRATE
  • PHLORETIN-2'-BETA-D-GLUCOSIDE
  • PHLORETIN 2'-BETA-D-GLUCOSIDE DIHYDRATE
  • PHLORETIN-2'-O-GLUCOSIDE DIHYDRATE
  • PHLORIDZIN
  • PHLORIDZIN DIHYDRATE
  • PHLORIZIN
  • 4',6'-DIHYDROXY-2'-(BETA-D-GLUCOSIDO)-3-(4-HYDROXYPHENYL) PROPIOPHENONE
  • 1-[2-(BETA-D-GLUCOPYRANOSYLOXY)-4,6-DIHYDROXYPHENYL]-3-(4-HYDROXYPHENYL)-1-PROPANONE
  • 2'-O-GLUCOSYL-4',6',4-TRIHYDROXYDIHYDROCHALCONE
  • 2'-O-GLUCOSYL-4',6',4-TRIHYDROXYDIHYDROCHALCONE DIHYDRATE
  • 2'-(beta-D-glucopyranosyloxy)-4',6'-dihydroxy-3-(4-hydroxyphenyl)propiophenone
  • 1-[2-(b-D-Glucopyranosyl-oxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
  • Phloretin-2b-glucosid
  • Phlorrhizen
  • 1-(2-(beta-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)-propan-1-on
  • phloridzosid
  • PHLORIDZIN(P)
  • 1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)oxan-2-yl]oxy}phenyl)-3-(4-hydroxyphenyl)propan-1-one
  • Phlorizin(Phloridzin)
  • 1-Propanone, 1-[2-(β-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-
  • Phlorizin 60-81-1
  • Phloridzin n-Hydrate, from Apple
  • NSC 2833
  • Phlorizin,>98%
  • Phlorinin
  • hot selling phloridzin
  • 60-81-1
  • C21H24O10xH2O
  • C21H24O10
  • C21H24O10H2O
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