(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron
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- CAS-Nr.
- 480-18-2
- Bezeichnung:
- (2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron
- Englisch Name:
- Taxifolin
- Synonyma:
- DIHYDROQUERCETIN;distylin;taxifoliol;Larch extract;(+)-TAXIFOLIN;(2R,3R)-(+)-Taxifolin;(2R,3R)-DIHYDROQUERCETIN;Taxifolin (Dihydroquercetin);CPD-474;Lavitol
- CBNumber:
- CB0402424
- Summenformel:
- C15H12O7
- Molgewicht:
- 304.25
- MOL-Datei:
- 480-18-2.mol
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(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron Eigenschaften
- Schmelzpunkt:
- 230-233°C (dec.)
- Siedepunkt:
- 365.09°C (rough estimate)
- Dichte
- 1.3326 (rough estimate)
- Brechungsindex
- 1.4790 (estimate)
- storage temp.
- -20°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 7.39±0.60(Predicted)
- Farbe
- White to Yellow
- BRN
- 5299277
- InChI
- InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1
- InChIKey
- CXQWRCVTCMQVQX-LSDHHAIUSA-N
- SMILES
- [C@H]1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O
- LogP
- 0.950
- CAS Datenbank
- 480-18-2(CAS DataBase Reference)
- EPA chemische Informationen
- 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)- (480-18-2)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| R-Sätze: |
22 |
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| S-Sätze: |
22-24/25 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
LK6920000 |
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| HazardClass |
IRRITANT |
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| HS Code |
29329990 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P332+P313 |
Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
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(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Taxifolin, a chemical substance extracted from pine plants such as larch
and Douglas fir. It belongs to the bioflavonoid pseudo-vitamin P, and
its scientific name is dihydroquercetin. Japanese scholar Fukui first
isolated it from the leaves of conifers (Chamaecyparis obtusa), and its
biological activity was subsequently discovered and confirmed.
Chemische Eigenschaften
Yellow Solid
Verwenden
An antioxidant flavenoid.
Definition
ChEBI: A taxifolin that has (2R,3R)-configuration.
Application
Taxifolin is a flavonoid commonly found in onion, milk, French maritime
pine bark and Douglas fir bark. It is also used in
various commercial preparations like Legalon?, Pycnogenol?, and
Venoruton?. This review focuses on taxifolin’s biological activities and
related molecular mechanisms. It showed promising pharmacological
activities in the management of inflammation, tumors, microbial
infections, oxidative stress, cardiovascular, and liver disorders. The
anti-cancer activity was more prominent than other activities evaluated
using different in vitro and in vivo models. Further research on the
pharmacokinetics, in-depth molecular mechanisms, and safety profile
using well-designed randomized clinical studies are suggested to develop
a drug for human use.
Allgemeine Beschreibung
Taxifolin is a plant flavonoid, which may find applications in the treatment of coronary heart disease, angina pectoris, cerebral thrombosis, cerebral infarction and sequelae.
(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 422)Lieferanten
480-18-2((2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron)Verwandte Suche:
(S)-2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4-benzopyron
Quercetin dihydrate
Paclitaxel
Docetaxel
5-Hydroxy-2-methyl-1,4-naphthochinon
3β-Hydroxyolean-12-en-28-sure
1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylen-7,14-dion
1,8-Dihydroxy-3-methylanthrachinon
Quercetin
(2R-trans)-2,3-Dihydro-3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4-benzopyron
(+)-TAXIFOLIN
(2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyron
- 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4h-1-benzopyran-4-on
- 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4h-1-benzopyran-4-on(
- 2,3-dihydro-3,3’,4’,5,7-pentahydroxy-flavon
- 2theta-trans)-
- 3,3’,4’,5,7-pentahydroxy-flavanon
- dihydro-querceti
- TAXIFOLIN(P)
- TAXIFOLIN, (+)-(RG)
- (2R-trans)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyrone
- Dihydroquercetin,~99%
- TAXIFOLIN SNAP-N-SHOOT 0.1mg/mL(P)
- (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-4-one
- (+)-Taxifolin ,98%
- (+)-trans Taxifolin
- 2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)-
- 2-(3,4,5-Trihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-4H-1-benzopyran-4-one
- (3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one
- 4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro
- taxifolin or dihydroquercetin
- CPD-474
- trans dihydroquercetin
- (2R,3R)-3,3′,4′,5,7-Pentahydroxyflavanone
(2R,3R)-Dihydroquercetin
- (2R,3R)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-1-benzopyran-4-one
- Diquertin
- Lariksin
- Lavitol
- (+)-3,3',4',5,7-PENTAHYDROXYFLAVANONE
- 3,3',4',5,7-PENTAHYDROXYFLAVANONE
- (2R,3R)-3,3',4',5,7-PENTAHYDROXYFLAVANONE
- 3,5,7,3',4'-PENTAHYDROXYFLAVANONE
- (+)-DIHYDROQUERCETIN
- TAXIFOLIN
- TAXIFOLIN, (+)-
- Taxifoliol,Distylin
- 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroMan-4-one
- Taxifolin SynonyMs (2R,3R)-3,3',4',5,7-Pentahydroxyflavanone
- 4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-
- (2S,3S)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one
- 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4-chromanone
- 3,3',4',5,7-Pentahydroxydihydroflavone
- 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R-trans)-
- FLAVANONE, 3,3',4',5',7-PENTAHYDROXY
- (2R,3R)-2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-5-olate
- Taxifolin，TAX
- Taxifolin USP/EP/BP
- (+)-(2R,3R)-Dihydroquercetin
- (+)-Dihydroquercetin
- Dihydroquercetin/Taxifolin
- (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one
- distylin
- (2R,3R)-(+)-Taxifolin
- DIHYDROQUERCETIN
- Taxifolin (Dihydroquercetin)
- Larch extract
- (2R,3R)-DIHYDROQUERCETIN
- (+)-TAXIFOLIN
- taxifoliol
- (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one
