1-Butylbiguanidmonohydrochlorid
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- CAS-Nr.
- 1190-53-0
- Bezeichnung:
- 1-Butylbiguanidmonohydrochlorid
- Englisch Name:
- BuforMin Hydrochloride
- Synonyma:
- BUTYL-BIGUANIDE HYDROCHLORIDE;Andere;Adebit;TideMol;Biforon;Sindiatil;PanforMin;Ziavetine;NSC528218;Aids126511
- CBNumber:
- CB0407151
- Summenformel:
- C6H16ClN5
- Molgewicht:
- 193.68
- MOL-Datei:
- 1190-53-0.mol
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1-Butylbiguanidmonohydrochlorid Eigenschaften
- Schmelzpunkt:
- 177-179?C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Stabilität:
- Hygroscopic
- CAS Datenbank
- 1190-53-0
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| R-Sätze: |
22-43-36 |
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| S-Sätze: |
36/39-46 |
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| HS Code |
29212900 |
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| Toxizität |
LD50 i.p. in mice: 380 mg/kg (Rikimaru) |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H318 |
Verursacht schwere Augenschäden. |
Schwere Augenschädigung |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P280, P305+P351+P338, P310 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P271 |
Nur im Freien oder in gut belüfteten Räumen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P332+P313 |
Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
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1-Butylbiguanidmonohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Buformin is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. It can also deactivate the glycolytic pathway by suppressing glyceraldehyde 3-phosphate dehydrogenase gene expression, which can lead to lactic acidosis. Biguanides, such as buformin, are reported to inhibit the mitochondrial respiratory complex I by inhibiting ubiquinone reduction and by stimulating reactive oxygen species production
via the complex I flavin. Some biguanides, including buformin, can also inhibit the mitochondrial ATP synthase. Buformin has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.
Chemische Eigenschaften
White Solid
Verwenden
BuforMin Hydrochloride is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. BuforMin Hydrochloride has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.
1-Butylbiguanidmonohydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-Butylbiguanidmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 97)Lieferanten
1190-53-0(1-Butylbiguanidmonohydrochlorid)Verwandte Suche:
Guanidiniumchlorid
Chlorhexidindihydrochlorid
Chlorhexidindi(acetat)
Biguanid
1-Butylbiguanidmonohydrochlorid
D-Gluconsure, Verbindung mit N,N''-Bis(4-chlorphenyl)-3,12-diimino-2,4,11,13-tetraazatetradecandiamidin (2:1)
Alexidin
N,N''-Bis(4-chlorphenyl)-3,12-diimino-2,4,11,13-tetraazatetrade-candiimidamid
1-Cyclohexylbiguanidmonohydrochlorid
- 1-Butylbigyanidine hydrochloride
- 1-Butylbiguanide Hydrochloride
- N-ButylidodicarboniMidic DiaMide Hydrochloride
- PanforMin
- Sindiatil
- TideMol
- Ziavetine
- Adebit
- Aids126511
- Aids-126511
- Andere
- Biforon
- Biguanide, 1-butyl-, hydrochloride
- BUFORMINE HCL
- BUFORMINE HYDROCHLORIDE
- N-BUTYL BIGUANIDE HYDROCHLORIDE
- 1-butylbiguanide monohydrochloride
- n-butylbiguanideHCl
- 1-Butyl-3-carbamimidoyl-guanidine hydrochloride
- Buformin hydrochloride (JAN)
- Dibetos-B (TN)
- N-butylimidodicarbonimidic diamide hydrochloride
- buformin hydrochloride
- Buformin hydrochloride solution in Methanol，100μg/mL
- BuforMin Hydrochloride USP/EP/BP
- Buformin HclQ: What is
Buformin Hcl Q: What is the CAS Number of
Buformin Hcl Q: What is the storage condition of
Buformin Hcl Q: What are the applications of
Buformin Hcl
- Imidodicarbonimidic diamide, N-butyl-, hydrochloride (1:1)
- NSC 528218
- NSC528218
- NSC-528218
- BUTYL-BIGUANIDE HYDROCHLORIDE
- agent,Type II diabete,inhibit,Buformin hydrochloride,Inhibitor,SKBR3,cervical cancer,breast cancer,AMPK,biguanide analog,BT474,1-Butylbiguanide,antidiabetic,AMP-activated protein kinase,Buformin
- N-Butylbiguanide Hydrochloride v
- Buformin hydrochloride >=98% (HPLC)
- 1190-53-0
- C6H16ClN5
- C6H15N5HCl
- Amines
- Intermediates & Fine Chemicals
- Pharmaceuticals
