Sancycline
|
|
|
- CAS-Nr.
- 808-26-4
- Englisch Name:
- Sancycline
- Synonyma:
- Sancycline Hydrochloride;(4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide;CS-676;GS 2147;Bonomycin;NSC-51812;Norcycline;SANCYCLINE;Sancyclinum;808-26-4 Sancycline
- CBNumber:
- CB0420370
- Summenformel:
- C21H22N2O7
- Molgewicht:
- 414.41
- MOL-Datei:
- 808-26-4.mol
|
Sancycline Eigenschaften
- Schmelzpunkt:
- 224-2280C (dec)
- Siedepunkt:
- 750.9±60.0 °C(Predicted)
- Dichte
- 1.61±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- Löslichkeit
- Aqueous Acid (Slightly), Chloroform (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 4.50±1.00(Predicted)
- Farbe
- Beige to Dark Beige
- Stabilität:
- Hygroscopic
- CAS Datenbank
- 808-26-4
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H362 |
Kann Säuglinge über die Muttermilch schädigen. |
Reproductive toxicity, effects on or via lactation |
Additional category |
|
|
P201, P260, P263, P264, P270,P308+P313 |
|
| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P263 |
Kontakt während der Schwangerschaft /und der Stillzeit vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
|
Sancycline Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC
90s = 1 and 32 μg/ml, respectively). Sancycline is active against tetracycline-resistant
E. coli,
S. aureus, and
E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml.
In vivo, sancycline is active against
S. aureus in mice with ED
50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively.
Chemische Eigenschaften
Yellow Solid
Verwenden
Sancycline is a rare semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of declomycin, first reported in 1962. As the simplest of the early tetracyclines, sancycline was the first to be totally synthesised by Conover and co-workers. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.
Sancycline Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Sancycline Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 181)Lieferanten
808-26-4()Verwandte Suche:
Salinomycin
Salicylanilid
Minocycline
Metacyclinhydrochlorid
[4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacen-2-carboxamidmonohydrochlorid
N,N-Dimethyl-1,3-diaminopropan
Cyclosporin A
Oxytetracyclinhydrochlorid
Deslanosid
Doxycyclin
Pipacyclin
Meclocyclin
Tetracyclinhydrochlorid
Chlortetracyclin
2-Naphthacencarboxamid, N-[[4-[[(Aminoiminomethyl)amino]iminomethyl]-1-piperazinyl]methyl]-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Dihydrochlorid, [4S-(4α,4aα,5aα,6β,12aα)]-
Metaphosphorsure, Natriumsalz, Verbindung mit [4S-(4α,4aα,5aα,6β,12aα)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacencarboxamid
2-Naphthacencarboxamid, 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochlorid, [4S-(4α,4aα,5α,5aα,6α,12aα)]-
Tetracyclin
- SANCYCLINE
- (4S,4aS,5aR,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1-11-dioxo-2-naphthacenecarboxamide
- 6-Demethyl-6-deoxytetracycline
- Bonomycin
- GS 2147
- Norcycline
- (4S,4aS,5aR,12aS)-4-(Dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-naphthacenecarboxamide
- NSC-51812
- Minocycline IMpurity B
- 2-NaphthacenecarboxaMide,4-(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,(4S,4aS,5aR,12aS)-
- 6-DeMethyl-6-deoxytetracycline, BonoMycin, Norcycline
- BONOMYCIN; NORCYCLINE;6-DEMETHYL-6-DEOXYTETRACYCLINE
- Minocycline EP Impurity B/Sancycline/(4S,5aS,8Z,10E,14aS)-4-(dimethylamino)-3,11,14,14a-tetrahydroxy-1,13-dioxo-1,4,4a,5,5a,6,7,12,13,14a-decahydrocyclodeca[b]naphthalene-2-carboxamide
- CS-676
- Sancycline in stock Factory
- Sancycline (Bonomycin
- Sancyclinum
- Minocycline EP Impurity B (Sancycline)
- SancyclineQ: What is
Sancycline Q: What is the CAS Number of
Sancycline Q: What is the storage condition of
Sancycline Q: What are the applications of
Sancycline
- 808-26-4 Sancycline
- Sancycline Hydrochloride
- (4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
- 808-26-4
- 208538-73-6
- C21H22N2O7
- C21H23ClN2O7
- Intermediates & Fine Chemicals
- Pharmaceuticals
