O-Phosphoserin
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- CAS-Nr.
- 407-41-0
- Bezeichnung:
- O-Phosphoserin
- Englisch Name:
- O-Phospho-L-serine
- Synonyma:
- L O;P-ser;L-SOP;L-O-(RG);Seriphos;P-serine;Fosforina;3-P-SERINE;Phospho Ser;Phospho?Ser
- CBNumber:
- CB0456205
- Summenformel:
- C3H8NO6P
- Molgewicht:
- 185.07
- MOL-Datei:
- 407-41-0.mol
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O-Phosphoserin Eigenschaften
- Schmelzpunkt:
- 190 °C(lit.)
- alpha
- [α]D20 +14～+18°(c=5,dil.HCl)
- Siedepunkt:
- 475.4±55.0 °C(Predicted)
- Dichte
- 1.809±0.06 g/cm3(Predicted)
- Dampfdruck
- 0Pa at 20℃
- storage temp.
- under inert gas
- Löslichkeit
- H2O: 50 mg/mL hot, clear, colorless to slightly yellow
- Aggregatzustand
- Crystalline Powder
- pka
- pK1:2.08;pK2:5.65;pK3:9.74 (25°C)
- Farbe
- White
- Wasserlöslichkeit
- 28.34g/L at 20℃
- Merck
- 14,7363
- BRN
- 1726826
- InChIKey
- BZQFBWGGLXLEPQ-UWTATZPHSA-N
- CAS Datenbank
- 407-41-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
21/22 |
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| S-Sätze: |
36/37 |
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| RIDADR |
UN 3261 8 / PGII |
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| WGK Germany |
3 |
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| F |
10 |
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| HS Code |
29225090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H314 |
Verursacht schwere Verätzungen der Haut und schwere Augenschäden. |
Ätzwirkung auf die Haut |
Kategorie 1B |
Achtung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P330+P331 |
BEI VERSCHLUCKEN: Mund ausspülen. KEIN Erbrechen herbeiführen. |
| P303+P361+P353 |
BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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O-Phosphoserin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
O-
Phospho-
L-
Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC
50s = 2-
5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.
Chemische Eigenschaften
White powder
Verwenden
O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.
Allgemeine Beschreibung
Monoclonal Anti-Phosphoserine (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
Biologische Aktivität
Group III metabotropic glutamate receptor agonist; analog of L-AP4 (L-(+)-2-Amino-4-phosphonobutyric acid ). Inhibits proliferation and enhances neuronal differentiation in progenitor cells.
läuterung methode
Recrystallise the phospho-serine by dissolving 10g in H2O (150mL) at 25o, stirring for up to 20minutes. Undissolved material is filtered off (Büchner), and 95% EtOH (85mL) is added dropwise during 4minutes, and set aside at 25o for 3hours, then at 3o overnight. The crystals are washed with 95% EtOH (100mL), then dry Et2O (50mL), and dried in a vacuum (yield 6.5g). A further quantity (1.5g) can be obtained by keeping the mother liquors and washings at -10o for 1 week. The DL-isomer has m 167-170o(dec) after recrystallisation from H2O/EtOH or MeOH. [Neuhaus & Korkes Biochemical Preparations 6 75 1958, Neuhaus & Byrne J Biol Chem 234 113 1959, IR: F.lsch & Mellander Acta Chem Scand 11 1232 1957, Beilstein 4 IV 3120.]
O-Phosphoserin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
O-Phosphoserin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 200)Lieferanten
407-41-0(O-Phosphoserin)Verwandte Suche:
- L-O-PHOSPHOSERINE
- L-SERINE-O-PHOSPHATE
- L-PHOSPHOSERINE
- H-SER(PO3H2)-OH
- PHOSPHATIDYLETHANOLAMINE(EGG)(RG)
- O-Phosho-L-serine
- O-Phosphorylserine
- Phospho-L-serine
- Serine O-phosphate
- (S)-2-aMino-3-(phosphonooxy)propanoic acid
- L-Serine, O-phosphono-
- L-O-Phosphoserine
- Monoclonal Anti-Phosphoserine?Agarose antibody produced in mouse
- Monoclonal Anti-Phosphoserine?Biotin antibody produced in mouse
- Monoclonal Anti-Phosphoserine antibody produced in mouse
- Monoclonal Anti-Phosphoserine?FITC antibody produced in mouse
- Phospho Ser
- Phospho?Ser
- H-Ser(PO3H2)
- L-Ser(H2PO3)-OH
- O-Phospho-L-serine≥ 99% (Titration)
- H-SER(P)-OH
- H-SER(H2PO3)-OH
- L-2-AMINO-3-HYDROXYPROPANOIC ACID 3-PHOSPHATE
- PHOSPHOSERINE
- PHOSPHOSERINE ANTIBODY INHIBITOR
- O-PHOSPHORYL-L-SERINE
- dexfosfoserine
- L-(+)-serine 3-(dihydrogen phosphate)
- L-Phosphoserine Anhydrous
- Phosphoserinebariumsalt
- O-PHOSPHO-L-SERINE
- SERINE(PO3H2)-OH
- O-phosphoserine
- Serine phosphate
- (2S)-2-amino-3-phosphonooxy-propanoic acid
- L-O-(RG)
- plasmenylserine
- L-Serine monophosphoric acid
- L-O-Phosphoserine 98+% T
- L-2-Amino-3-hydroxypropanoic acid 3-phosphate, L-Serine O-phosphate, L-SOP
- L-O-Serine phosphate
- L-Serine, dihydrogen phosphate (ester)
- Seriphos
- Fosforina
- L-Serine dihydrogen phosphate
- L-Serine O-phosphoric acid
- 3-phospho-L-serine
- 3-phosphoserine
- 3-phospho-serine
- 3-P-SERINE
- phosphorylserine
- P-ser
- P-serine
- L-SOP
- O-Phospho-L-Serine,>95%(Ti)
- O-Phospho-L-serine Standard
- L O
