ANTI-DNMT1

ANTI-DNMT1 Struktur
CAS-Nr.
Englisch Name:
ANTI-DNMT1
Synonyma:
Anti-MCMT;Anti-DNMT;Anti-MHsaI;Anti-CXXC9;ANTI-DNMT1;Anti-FLJ16293;Anti-MGC104992;Anti-DNA MTase HsaI;ANTI-DNA METHYLTRANSFERASE;ANTI-DNA METHYLTRANSFERASE-1
CBNumber:
CB0479747
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

ANTI-DNMT1 Eigenschaften

storage temp. 
-20°C
Aggregatzustand
buffered aqueous solution

Sicherheit

WGK Germany  -

ANTI-DNMT1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Anti-DNMT1 antibody produced in rabbit is suitable for microarray and immunoblotting at a working concentration of 0.5-1.0μg/mL using nuclear extracts of 293T or HeLa cells. It was used at 1:1000 working dilution for immunoblot analysis in a study to analyze whether some miRNAs are aberrantly expressed and target DNMT1 in NiS (nickel sulfide)-transformed cells. It was used for immunoprecipitation of DNMT1 from nuclear lysates of colon cancer cells transfected with DNMT1 vectors in a study. It was used as a primary antibody at a working dilution of 1:1000 for western blot analysis of total protein extracted from left murine testis tissue exposed to low-dose-rate radiation in a study.

Allgemeine Beschreibung

In humans, the gene encodes a DNA (cytosine-5)-methyltransferase with 1616 amino acids. The N-terminal contains the regulatory domain, while the C-terminal region contains the catalytic domain. Two isoforms of DNMT1 have been isolated, DNMT1a and DNMT1b, the difference residing in 16 extra amino acids within the latter.

Biochem/physiol Actions

DNMT1 (DNA (cytosine-5-)-methyltransferase 1) is involved in the maintenance of methylation in somatic cells. During DNA methylation, DNMT1 helps to form the correct pattern of DNA strand by arranging heterochromatin. The CXXC region shows higher binding affinity for unmethylated DNA compare to the hemimethylated or methylated DNA. By binding to the CpG dinucleotide, it hypermethylates CpG islands as well as helps in silencing of tumor suppressor genes. Alteration in DNMT1 activity leads to various human diseases such as cancer and genetic disorders.

ANTI-DNMT1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ANTI-DNMT1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 15)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80
Shanghai guandao biology engineering co., ltd 18818239863 18818239863
3171921642@qq.com China 8884 58

  • Anti-DNMT1 antibody produced in rabbit
  • Anti-CXXC9
  • Anti-DNMT
  • Anti-DNMT1 antibody produced in goat
  • Anti-FLJ16293
  • Anti-CXXC-type zinc finger protein 9
  • Anti-DNA (cytosine-5)-methyltransferase 1
  • Anti-DNA methyltransferase HsaI
  • Anti-DNA MTase HsaI
  • Anti-MCMT
  • Anti-MHsaI
  • Anti-MGC104992
  • Monoclonal Anti-DNMT1 antibody produced in mouse
  • Anti-DNMT1 antibody produced in chicken
  • ANTI-DNMT1
  • ANTI-DNA METHYLTRANSFERASE
  • ANTI-DNA METHYLTRANSFERASE-1
  • Primary Antibodies
  • Antibodies
  • Antibodies for Gene Regulation and Expression
  • Antibodies in Chromatin Remodeling
  • Antibodies to Modifying Enzymes/DNA Methylation
  • BioChemical
  • Cell Biology
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