m-Aminobenzamid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
The poly(ADP-
ribose) polymerases (PARPs) comprise a family of enzymes which post-
translationally modify proteins by poly(ADP-
ribosyl)ation. Since some PARPs are activated by DNA strand breaks, PARP signaling has roles in DNA repair, apoptosis, inflammation, and other cellular responses. 3-
amino Benzamide is an inhibitor of PARPs (K
i = 1.8 μM). Through its effects on PARPs, 3-
amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-
mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.
Chemische Eigenschaften
beige powder
Verwenden
3-Aminobenzamide is used as an endogenous poly-ADP-ribosyltransferase inhibitor. Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It displays neuroprotective, anti-necrotic effects.
Definition
ChEBI: A substituted aniline that is benzamide in which one of the meta- hydrogens is replaced by an amino group.
m-Aminobenzamid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
