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Uridin-2',3',5'-triacetat

2',3',5'-Tri-O-acetyluridine Struktur
4105-38-8
CAS-Nr.
4105-38-8
Bezeichnung:
Uridin-2',3',5'-triacetat
Englisch Name:
2',3',5'-Tri-O-acetyluridine
Synonyma:
TAU;Uridine triacetate;(2R,3R,4R,5R)-2-(AcetoxyMethyl)-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate;MTBT1;MAPTL;RG 2133;Vistonuridine;2',3',5'-TriacetyL;Tri-O-acetyl uridine;2',3',5'-Tri-O-acety
CBNumber:
CB0687805
Summenformel:
C15H18N2O9
Molgewicht:
370.31
MOL-Datei:
4105-38-8.mol
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Uridin-2',3',5'-triacetat Eigenschaften

Schmelzpunkt:
127.0 to 131.0 °C
Dichte
1.43±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
Löslichkeit
Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly)
Aggregatzustand
Solid
pka
9.39±0.10(Predicted)
Farbe
Off-White
InChI
InChI=1S/C15H18N2O9/c1-7(18)23-6-10-12(24-8(2)19)13(25-9(3)20)14(26-10)17-5-4-11(21)16-15(17)22/h4-5,10,12-14H,6H2,1-3H3,(H,16,21,22)/t10-,12-,13-,14-/m1/s1
InChIKey
AUFUWRKPQLGTGF-QRMSVCKNSA-N
SMILES
C(OC(=O)C)[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC(=O)C)[C@@H]1OC(=O)C
CAS Datenbank
4105-38-8(CAS DataBase Reference)

Sicherheit

S-Sätze: 24/25
WGK Germany  3
HS Code  29349990

Uridin-2',3',5'-triacetat Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Uridine triacetate is an orally available pro-drug of uridine approved by the FDA for the treatment of the rare autosomal recessive disorder called hereditary orotic aciduria. The drug was also approved for treating overdose of two chemotherapies (fluorouracil and capecitabine). Uridine triacetate was developed by Wellstat Therapeutics and licensed to BTG.

Chemische Eigenschaften

White or almost white crystalline powder

Verwenden

2’,3’,5’-Triacetyluridine is used in the treatment of Alzheimer’s disease in mice and provide neuroprotective effects. Shown to also decrease depressive symptoms and increases in brain pH bipolar patients.

Definition

ChEBI: Uridine triacetate is an acetate ester that is uracil in which the three hydroxy hydrogens are replaced by acetate group. A prodrug for uridine, it is used for the treatment of hereditary orotic aciduria and for management of fluorouracil toxicity. It has a role as a prodrug, a neuroprotective agent and an orphan drug. It is a member of uridines and an acetate ester.

Uridin-2',3',5'-triacetat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

5-Bromuridin 3-METHYL URIDINE

Uridin-2',3',5'-triacetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 300)Lieferanten
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Wuhu Nuowei chemistry Co., Ltd.
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Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
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Accela ChemBio Inc. 		(+1)-858-699-3322
info@accelachem.com United States 19965 58

4105-38-8(Uridin-2',3',5'-triacetat)Verwandte Suche:

Guanosin-2',3',5'-triacetat 1-β-D-Arabinofuranosyl-(1H,3H)-pyrimidin-2,4-dion Doxifluridin 5-Fluor-2'-desoxyuridin Sodium triacetoxyborohydride Trifluridin uridine diphosphate glucose {= UDP-glucose} Uracil Oxydiethylendi(acetat) Tetrahydrofurfurylacetat 2-(1-Methylethoxy)ethylacetat 2'-Desoxyuridin Uridin-2',3',5'-tribenzoat Uridin-2',3',5'-triacetat
  • 2'', 3'', 5''-TRIACETYLURIDINE (2'', 3'', 5''-TRI-O-ACETYLURIDINE)
  • RG 2133
  • Tri-O-acetyl uridine
  • Vistonuridine
  • 1-((2R,3R,4R,5R)-3,4-Diacetyl-3,4-dihydroxy-5-(1-hydroxy-2-oxopropyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
  • 2',3',5'-Tri-O-acetyl-rU
  • 1-((2R,3R,4R,5R)-3,4-Diacetyl-3,4-dihydroxy-5-(1-hydroxy-2-oxopropyl)tetrahydrofuran-2-yl)pyrimid
  • ANTI-TAU(C-TERMINAL) antibody produced in rabbit
  • MAPTL
  • Microtubule-associated protein tau
  • MTBT1
  • ANTI-TAU (MAPT) (S720) antibody produced in rabbit
  • [4-acetoxy-2-(acetoxymethyl)-5-(2,4-dioxopyrimidin-1-yl)tetrahydrofuran-3-yl] acetate
  • [4-acetyloxy-2-(acetyloxymethyl)-5-(
  • [4-acetyloxy-2-(acetyloxymethyl)-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl] acetate
  • 2-(acetoxymethyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate
  • 2-[(acetyloxy)methyl]-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate
  • acetic acid [4-acetoxy-2-(acetoxymethyl)-5-(2,4-diketopyrimidin-1-yl)tetrahydrofuran-3-yl] ester
  • acetic acid [4-acetoxy-2-(acetoxymethyl)-5-(2,4-dioxo-1-pyrimidinyl)-3-tetrahydrofuranyl] ester
  • 1-((2R,3R,4R,5R)-3,4-Diacetyl-3,4-dihydroxy-5-(1-hydroxy-2-oxopropyl)tetrahydrofuran-2-yl)pyri
  • (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4
  • 2',3',5'-tri-O-Acetyluridine≥ 98% (HPLC)
  • URIDINE 2',3',5'-TRIACETATE
  • 2',3',5'-TRI-O-ACETYLURIDINE
  • 2',3',5'-TRIACETYLURIDINE
  • 1-(2-O,3-O,5-O-Triacetyl-β-D-ribofuranosyl)-4-hydroxypyrimidine-2(1H)-one
  • [(2R,3R,4R,5R)-4-acetyloxy-2-(acetyloxymethyl)-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl] acetate
  • [(2R,3R,4R,5R)-4-acetyloxy-2-(acetyloxymethyl)-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl] ethanoate
  • acetic acid [(2R,3R,4R,5R)-4-acetoxy-2-(acetoxymethyl)-5-(2,4-diketopyrimidin-1-yl)tetrahydrofuran-3-yl] ester
  • 2',3',5'-Tri-O-acety
  • [(2S,3R,4S,5S)-3,4-bis(acetyloxy)-5-(2,4-dioxo-1,2,3,4-tetrahydropyriMidin-1-yl)oxolan-2-yl]Methyl acetate
  • 2',3',5'-Tri0acetyluridine
  • 2`,3`,5`-Tracetyluridine
  • 2',3',5'-Tri-O-acetyl-D-uridine
  • (Ser232) BioAssay&trade
  • Phospho-14-3-3 &theta
  • phosphorylated (S232)
  • 2',3',5'-TriacetyL
  • 2',3',5'-Tri-O-acetyluridine USP/EP/BP
  • Uridine triacetate
  • (2R,3R,4R,5R)-2-(AcetoxyMethyl)-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate
  • TAU
  • Mouse Anti-Tau antibody
  • 2',3',5'-Tri-O-acetyluridine
  • 4105-38-8
  • 4105-38-3
  • C15H18N2O9
  • Biochemicals and Reagents
  • BioChemical
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides
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