Miconazolnitrat

Miconazole nitrate Struktur
22832-87-7
CAS-Nr.
22832-87-7
Bezeichnung:
Miconazolnitrat
Englisch Name:
Miconazole nitrate
Synonyma:
monistat;Isoconazole IMpurity C Nitrate (Miconazole Nitrate);Ecobi;Vodol;Daktar;Florid;Aflorix;Brentan;Hi-Pick;Micatin
CBNumber:
CB0705402
Summenformel:
C18H15Cl4N3O4
Molgewicht:
479.14
MOL-Datei:
22832-87-7.mol

Miconazolnitrat Eigenschaften

Schmelzpunkt:
170-185 C
Dichte
1.5000 (rough estimate)
Brechungsindex
1.6200 (estimate)
storage temp. 
2-8°C
Löslichkeit
pyridine: soluble50mg/mL
Farbe
white to off-white
Optische Aktivität
[α]25/D 0°, c = 10 in water
Wasserlöslichkeit
Slightly soluble in water. Soluble in propylene glycol or pyridine.
Merck 
14,6178
InChIKey
MCCACAIVAXEFAL-UHFFFAOYSA-N
CAS Datenbank
22832-87-7(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22-43-40
S-Sätze: 36/37
RIDADR  3249
WGK Germany  3
RTECS-Nr. NI4771000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933290000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Miconazolnitrat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R43:Sensibilisierung durch Hautkontakt möglich.
R40:Verdacht auf krebserzeugende Wirkung.

S-Sätze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Beschreibung

Miconazole is a widely used antifungal imidazole that acts by inhibiting the 14α-demethylation of lanosterol, which consequently leads to the inhibition of ergosterol synthesis in fungal cell membranes. Additionally, miconazole has been shown to induce reactive oxygen species in fungal biofilms, demonstrating a MIC value of ≥256 μM against Candida spp.

Chemische Eigenschaften

White Solid

Verwenden

Antifungal (topical).

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Miconazole nitrate is an imidazole derivative and a broad spectrum antifungal drug used in the management of fungal outbreak in humans and veterinary animals.

Biologische Aktivität

Antifungal agent. Inhibits lanosterol demethylase and induces formation of reactive oxygen species.

Clinical Use

1-[2-(2,4-Dichlorophenyl)-2-[2,4-dichlorophenyl]-methoxy]ethyl]-1H-imidazole mononitrate (Monistat,Micatin) is a weak base with a pKa of 6.65. The nitric acidsalt occurs as white crystals that are sparingly soluble inwater and most organic solvents.
The free base is available in an injectable form, solubilized with polyethylene glycol and castor oil, and intended for the treatment of serious systemic fungal infections, such as candidiasis, coccidioidomycosis, cryptococcosis, petriellidiosis, and paracoccidioidomycosis. It may also be used for the treatment of chronic mucocutaneous candidiasis. Although serious toxic effects from the systemic administration of miconazole are comparatively rare, thrombophlebitis, pruritus, fever, and gastrointestinal upset are relatively common. Miconazole nitrate is supplied in various dosage forms (cream, lotion, powder, and spray) for the treatment of tinea infections and cutaneous candidiasis. Vaginal creams and suppositories are also available for the treatment of vaginal candidiasis. A concentration of 2% of the salt is used in most topical preparations.

Miconazolnitrat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Miconazolnitrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 635)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666
sales@hbmojin.com China 12409 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5960 58
Changzhou Rokechem Technology Co., Ltd.
18758118018
sales001@rokechem.com China 255 58
Shanghai Bojing Chemical Co.,Ltd.
+86-86-02137122233 +8613795318958
bj1@bj-chem.com China 297 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21703 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714
fandachem@gmail.com China 9359 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
bruce@xrdchem.cn CHINA 566 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763
info@tnjchem.com China 2989 55
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29919 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58

22832-87-7(Miconazolnitrat)Verwandte Suche:


  • NSC 169434 Nitrate
  • 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-, nitrate (1:1)
  • ()-MICONAZOLE NITRATE SALT, IMIDAZO
  • 1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole 1-[2-(2,4-Dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole Nitrate
  • MICONAZOLE NITRATE USP
  • MiconazoleNitrate-Bp/Ep/Usp
  • 1-(2,4-dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole
  • MICONAZOLE(RG)
  • Miconazole Nitrate (200 mg)
  • Miconazole Nitrate (200 mg)J0D0110.997mg/mg(dr)
  • MICONAZOLE NITRATE SALT, (+/-)-(RG)
  • LABOTEST-BB LT00134678
  • 1-[2,4-DICHLORO BETA-[2,4-DICHLOROBENZYL]OXY]-PHENETHYL]IMIDAZOLE NITRATE
  • 1-[2,4-DICHLORO-BETA-([2,4-DICHLOROBENZYL]OXY)-PHENETHYL]IMIDAZOLE NITRATE SALT
  • 1-[2-(2,4-DICHLOROBENZYLOXY)-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE NITRATE
  • (+/-)MICONAZOLE NITRATE SALT
  • 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)-imidazolmononitra
  • 1h-imidazole,1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)
  • daktacort
  • daktarin
  • daktarintalc
  • Miconazole nitrate
  • 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazolenitrate
  • (±)-Miconazole nitrate salt,1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole
  • [2,4-Dichloro-b-(2,4-dichlorobenzyloxy)phenethyl]imidazole nitrate
  • 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-, mononitrate (9CI)
  • Aflorix
  • Albistat
  • Andergin
  • Antifungal Cream
  • Brentan
  • Conoderm
  • Conofite
  • Daktar
  • Deralbine
  • Dermonistat
  • Ecobi
  • Epi-Monistat
  • Florid
  • Fungiderm
  • Fungisdin
  • Gyno-Daktarin
  • Gyno-Monistat
  • Hi-Pick
  • Loptrimin AF Jock-Itch Powder Aerosol
  • Lotrimin AF Powder
  • Lotrimin AF Powder Aerosol
  • Lotrimin AF Spray Liquid
  • Micatin
  • Miconal
  • Micotef
  • Monistat Cream and Suppositories
  • Monistat-Derm
  • NSC 169434
  • Prilagin
  • R 14889
  • Vodol
  • MICONAZOLE NITRATE USP24
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