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N-Methylhyosciniumbromid Produkt Beschreibung

METHSCOPOLAMINE BROMIDE Struktur
155-41-9
CAS-Nr.
155-41-9
Bezeichnung:
N-Methylhyosciniumbromid
Englisch Name:
METHSCOPOLAMINE BROMIDE
Synonyma:
blocan;diopal;nutrop;pamine;ampyrox;holopan;holopon;mescopil;paraspan;-tropate
CBNumber:
CB0746986
Summenformel:
C18H24BrNO4
Molgewicht:
398.29
MOL-Datei:
155-41-9.mol

N-Methylhyosciniumbromid Eigenschaften

Schmelzpunkt:
214-217 °C (decomp)
Brechungsindex
-24 ° (C=1, H2O)
Löslichkeit
H2O: 50 mg/mL
Aggregatzustand
powder
Farbe
white
Optische Aktivität
[α]25/D 25°, c = 5 in H2O(lit.)
Merck 
14,6003
CAS Datenbank
155-41-9
EPA chemische Informationen
3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9,9-dimethyl-, bromide (1:1), (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)- (155-41-9)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,N,Xn
R-Sätze: 23/24/25-50/53-20/21/22-20/21
S-Sätze: 36/37/39-45-61-60-36/37
RIDADR  UN 1544 6.1/PG 3
WGK Germany  3
RTECS-Nr. YM3675000
HazardClass  6.1
PackingGroup  III
HS Code  29399990
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H400 Sehr giftig für Wasserorganismen. Kurzfristig (akut) gewässergefährdend Kategorie 1 Warnung P273, P391, P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

N-Methylhyosciniumbromid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.

S-Sätze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.

Originator

Pamine,Upjohn,US,1953

Verwenden

anticholinergic

Verwenden

METHSCOPOLAMINE BROMIDE is the methylated derivative of Scopolamine (S200000), a muscarinic antagonist that is similar to acetylcholine. METHSCOPOLAMINE BROMIDE have been used for the treatment of peptic ulcers by reducing acid secretion of the stomach and is used to treat morning sickness.

Definition

ChEBI: A quaternary ammonium salt resulting from the reaction of the amino group of scopolamine with methyl bromide.

Manufacturing Process

In a one-liter separatory funnel, 94 g (0.215 mol) of scopolamine hydrobromide trihydrate was dissolved in 250 ml of water, made alkaline by shaking with 40 g (1 mol) of sodium hydroxide in 150 ml of water, and the free base immediately extracted with ether. As scopolamine is somewhat soluble in water, the aqueous layer was saturated with potassium carbonate and again extracted with ether. The combined ether extracts were dried over anhydrous magnesium sulfate and the ether removed by distillation, leaving 65 g (0.214 mol; 100% yield) of nearly colorless oil. Then 100 g (1.05 mols) of cold methyl bromide was added to a chilled, 500-ml pressure flask containing the 65 g of scopolamine, the flask stoppered tightly with a clamp, and allowed to stand at room temperature for 96 hours.
The flask was cooled before opening, excess methyl bromide removed by filtration, and the white solid washed thoroughly with dry ether. The yield of crude scopolamine methyl bromide was 80g (94% yield; 93.5% over-all yield).
The salt was recrystallized from 550 ml of alcohol; first crop, 70 g, MP 212° to 214°C; second crop, 6 g, MP 195° to 200°C. The combined crops were again recrystallized from 500 ml of 3-A alcohol; MP 210° to 212°C. The third recrystallization from 600 ml of alcohol yielded 64 g, MP 214° to 216°C, a 75% yield based on scopolamine hydrobromide trihydrate starting material.

Therapeutic Function

Spasmolytic

N-Methylhyosciniumbromid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


N-Methylhyosciniumbromid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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155-41-9(N-Methylhyosciniumbromid)Verwandte Suche:


  • METHSCOPOLAMINE BROMIDE
  • (-)SCOPOLAMINE METHYL BROMIDE
  • SCOPOLAMINE METHYL BROMIDE
  • (-)-tropate
  • ,9-dimethyl-,bromide,[7(s)-(1alpha,2beta,4beta,5alpha,7beta)]-
  • .0(2,4)]nonanebromide
  • 1alphah,5alphah-tropanium,6beta,7beta-epoxy-3alpha-hydroxy-8-methyl-,bromide,
  • 3-oxa-9-azoniatricyclo(3.3.1.0(2,4))nonane,7-(3-hydroxy-1-oxo-2-phenylpropoxy)
  • 3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane,7-(3-hydroxy-1-oxo-2-phenyl-
  • 3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane,7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9
  • 5-alpha-h-tropanium,6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-1-alpha-b
  • 5-alpha-h-tropanium,6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-1-alpha-br
  • 6beta,7beta-epoxy-3alpha-hydroxy-8-methyl-1alphah,5alphah-tropaniumbromide(-)
  • 7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9,9-dimethyl-3-oxo-9-azoniatricyclo-[3.3.1
  • -9,9-dimethyl-,bromide,(7(s)-(1alpha,2bet///
  • ampyrox
  • blocan
  • diopal
  • epoxymethaminebromide
  • epoxytropinetropatemethylbromide
  • holopan
  • holopon
  • lescopinebromide
  • mescopil
  • methoscopylaminebromide
  • methylbromidescopolamine
  • methylscopolaminebromide
  • methylscopolaminehydrobromide
  • neo-avagal
  • n-methylhyoscinebromide
  • n-methylscopolammoniumbromide
  • nutrop
  • omide,(-)-tropate(ester)
  • pamine
  • paminebromide
  • N-methylhyoscinium bromide
  • (-)-SCOPOLAMINE METHYL BROMIDE CHOLINERG IC ANTAGONIS
  • Hyoscine methobromide
  • Hyoscine methyl bromide, Methscopolamine bromide
  • (-)-Tropate(ester)
  • 1.alpha.-H,5.alpha.H-Tropanium, 6.beta.,7.beta.-epoxy-3.alpha.-hydroxy-8-methyl-, bromide, (-)-tropate
  • 1.alpha.H,5.alpha.H-Tropanium, 6.beta.,7.beta.-epoxy-3.alpha.-hydroxy-8-methyl-, bromide, (-)-tropate
  • 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9,9-dimethyl-, bromide, [7(S)-(1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)]-
  • Methscopolamine Bromide (200 mg)
  • 3-Oxa-9-azoniatricyclo3.3.1.02,4nonane, 7-(2S)-3-hydroxy-1-oxo-2-phenylpropoxy-9,9-dimethyl-, bromide, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-
  • (-)-Scopolaminmethylbromid
  • HYOSCINE METHYL BROMIDE
  • Hyoscine Butylbromide Impurity C
  • (1α,2β,4β,5α,7β)-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane, bromide (1:1)
  • paraspan
  • proscomide
  • restropin
  • romide,(-)-tropate(ester)
  • scopolaminemethobromide
  • -tropate
  • Hyoscine Hydrobromide EP Impurity C
  • Oxitropium bromide impurity B CRS
  • Homatropine Methylbromide EP Impurity D
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