Tenofovir disoproxil

Tenofovir disoproxil Struktur
201341-05-1
CAS-Nr.
201341-05-1
Englisch Name:
Tenofovir disoproxil
Synonyma:
SRY;Tdf;CS-589;GS 4331;Aids080741;Aids-080741;Bis(poc)pmpa;Pmpa prodrug;enofovirdisoproxil;Tenofov ir Disoprox
CBNumber:
CB0949152
Summenformel:
C19H30N5O10P
Molgewicht:
519.44
MOL-Datei:
201341-05-1.mol

Tenofovir disoproxil Eigenschaften

Siedepunkt:
642.7±65.0 °C(Predicted)
Dichte
1.45±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit
DMSO: ≥ 38 mg/mL (73.16 mM)
pka
4.20±0.10(Predicted)
CAS Datenbank
201341-05-1

Sicherheit

Tenofovir disoproxil Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Tenofovir disoproxil is a prodrug in a manner similar to that of adefovir dipivoxil. In both cases, the phosphate esters are removed through the action of plasma esterase, leading in this case to tenofovir, which differs from adefovir by the presence of the indicated methyl group. Tenofovir disoproxil exhibits good bioavailability (25%), which is improved in the presence of food (35%). The drug is approved for the treatment of HIV infections in adult patients. Tenofovir diphosphate is an HIV RT inhibitor. The active form of tenofovir is the tenofovir diphosphate, which competes with dATP for incorporation into viral DNA, and when incorporated, tenofovir diphosphate results in premature termination of DNA growth and inhibition of DNA polymerase. Tenofovir disoproxil is indicated for treatment-experienced patients with HIV-1. The drug also appears to be effective in treatment-naive patients, but initial approval is for treatment-experienced patients. The drug is administered as one tablet taken once daily. It is recommended that the drug be combined with other RT inhibitors or HIV PIs, which results in additive or synergistic activity.

Verwenden

Tenofovir Disoproxil is a therapeutic option for nucleos(t)ide analog (NA)-experienced chronic hepatitis B (CHB) patients infected with hepatitis B virus (HBV). Also, it is an intermediate used in the synthesis of Tenofovir Disoproxil Dimer (T018515), which is a Tenofovir Disoproxil impurity.

Definition

ChEBI: An organic phosphonate that is the disoproxil ester of tenofovir. A prodrug for tenofovir, an HIV-1 reverse transcriptase inhibitor, tenofovir disoproxil is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.

Allgemeine Beschreibung

Tenofovir disoproxil is a prodrug analogously with abacavir.Plasma and tissue esterases cleave the phosphateprotecting groups, releasing the active drug. The bioavailabilityof tenofovir is about 35% when administered withfood. The drug is approved by the Food and DrugAdministration (FDA) for the treatment of HIV infectionsin adult patients. Recommendations are for the drug to beadministered with other RT inhibitors or PIs to achievesynergism.

Tenofovir disoproxil Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Tenofovir disoproxil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 248)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+8613288715578
sales@hbmojin.com China 12452 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21700 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
Anqing Chico Pharmaceutical Co., Ltd.
15380796838
chloewu@chicopharm.cn CHINA 341 58
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282
alice@crovellbio.com China 8823 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22968 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63711 58
Shaanxi Dideu Medichem Co. Ltd
18192627656
1012@dideu.com China 3911 58

201341-05-1()Verwandte Suche:


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