ChemicalBook Deutsch Chinesisch   Japanisch   Englisch   Korea
ChemicalBook > Produktkatalog >Aktive pharmazeutische Wirkstoffe (APIs) >Antibiotika >Andere Antibiotika >Epothilone B

Epothilone B Produkt Beschreibung

CAS-Nr.152044-54-7
Bezeichnung:
Englisch Name:Epothilone B
Synonyma:
EPO 906A;atupilone;Patupilone;EPOTHILONE;Epothilone B;Epothilone B, >=98%;Epothilone B(EPO906);Patupilone(Epothilone B);Epothilone B(Patupilone);EPO906, EpoB, Patupilone
CBNumber:CB0972824
Summenformel:C27H41NO6S
Molgewicht:507.68
MOL-Datei:152044-54-7.mol
Epothilone B physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 95-97°C
alpha : D21 -35° (c = 0.7 in methanol)
Dichte: 1.136
storage temp. : Store at -20°C
Aggregatzustand: White to off-white solid
Farbe: colorless
InChIKey: QXRSDHAAWVKZLJ-PVYNADRNSA-N
CAS Datenbank: 152044-54-7
Sicherheit
WGK Germany : 3
HS Code : 29419090

Epothilone B Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White Powder
Verwenden
Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.
Verwenden
Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Like epothilone A, epothilone B acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.
Verwenden
Epothilone B (Epo B) is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis. It induces mitotic arrest at the G2-M transition in Hs578T and HeLa cells (IC50 = 3 and 32 nM, respectively) as well as in multidrug resistant KB3-1 and KBV-1 cells (IC50 = 16 and 92 nM, respectively). Epo B causes cell cycle arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer.
Definition
ChEBI: An epithilone that is epithilone D in which the double bond in the macrocyclic ring has been oxidised to the corresponding epoxide (the S,S stereoisomer).
Biologische Aktivität
Microtubule stabilization agent that promotes tubulin polymerization and induces G 2 -M cell cycle arrest (EC 50 = 3 - 92 nM). Potently inhibits a variety of human cancer cell lines (IC 50 values are 0.13 - 0.64 nM), including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent anticancer activity in numerous human tumor xenografts in vivo .
Epothilone B Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Epothilone B Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 138)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21968 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733sales@mainchem.com CHINA 32457 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20095 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409orders@qcchemical.com United States 8409 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19923 58
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499sales@biochembest.com; market@biochembest.com China 5967 61
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512
+86-510-68873513sales@cegchem.com China 1796 58
 
152044-54-7(Epothilone B)Verwandte Suche:
Amphotericin B Methyl-4-hydroxybenzoat 4-Hydroxybenzoesure 5-(2-Amino-5-O-carbamoyl-2-desoxy-L-xylonamido-1,5-didesoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1(2H)-pyrimidinyl)-β-D-allofuranuronsure [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacen-2-carboxamidmonohydrochlorid Gentamicin 10-Hydroxycamptothecin Doxycyclin Glykolsaeure Hydroxyacetonitril Clindamycin Lincomycin 2-(3,6-Dihydroxy-2,4,5,7-tetrabromxanthen-9-yl)-benzoesure Azithromycin Rapamycin 4-Hydroxybenzaldehyd Hydroxy silicone oil 4-Methoxyphenol
Epothilone B, >=98% Patupilone(Epothilone B) atupilone 4,17-Dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1S,3S,7S,10R,11S,12S,16R)- EPO 906A (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Epothilone B Patupilone ()-Epothilone B,EPO906, EpoB, Patupilone EPO906, EpoB, Patupilone Epothilone B(EPO906) Epothilone B HOUSE STANDARD 152044-54-7 Inhibitors Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds Epothilone B(Patupilone) (3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentaMethyl-3-((E)-1-(2-Methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dione Epothilone B (EPO906, Patupilone) EPOTHILONE (1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione Patupilone (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Urheberrecht 2017 © ChemicalBook. Alle Rechte vorbehalten.