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Epothilone B Produkt Beschreibung

Englisch Name:Epothilone B
EPO 906A;atupilone;Patupilone;EPOTHILONE;Epothilone B;Epothilone B, >=98%;Epothilone B(EPO906);Patupilone(Epothilone B);Epothilone B(Patupilone);EPO906, EpoB, Patupilone
Epothilone B physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 95-97°C
alpha : D21 -35° (c = 0.7 in methanol)
Dichte: 1.136
storage temp. : Store at -20°C
Aggregatzustand: White to off-white solid
Farbe: colorless
CAS Datenbank: 152044-54-7
WGK Germany : 3
HS Code : 29419090

Epothilone B Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White Powder
Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.
Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Like epothilone A, epothilone B acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.
Epothilone B (Epo B) is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis. It induces mitotic arrest at the G2-M transition in Hs578T and HeLa cells (IC50 = 3 and 32 nM, respectively) as well as in multidrug resistant KB3-1 and KBV-1 cells (IC50 = 16 and 92 nM, respectively). Epo B causes cell cycle arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer.
ChEBI: An epithilone that is epithilone D in which the double bond in the macrocyclic ring has been oxidised to the corresponding epoxide (the S,S stereoisomer).
Biologische Aktivität
Microtubule stabilization agent that promotes tubulin polymerization and induces G 2 -M cell cycle arrest (EC 50 = 3 - 92 nM). Potently inhibits a variety of human cancer cell lines (IC 50 values are 0.13 - 0.64 nM), including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent anticancer activity in numerous human tumor xenografts in vivo .
Epothilone B Upstream-Materialien And Downstream Produkte
Downstream Produkte
Epothilone B Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 138)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21968 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32457 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114 CHINA 6374 58
Chemwill Asia Co.,Ltd.
86-21-51086038;;; CHINA 24001 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20095 58
(323) 306-3136
(626) United States 8409 58
career henan chemical co
+86-371-86658258 CHINA 19923 58
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0); China 5967 61
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512 China 1796 58
152044-54-7(Epothilone B)Verwandte Suche:
Amphotericin B Methyl-4-hydroxybenzoat 4-Hydroxybenzoesure 5-(2-Amino-5-O-carbamoyl-2-desoxy-L-xylonamido-1,5-didesoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1(2H)-pyrimidinyl)-β-D-allofuranuronsure [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacen-2-carboxamidmonohydrochlorid Gentamicin 10-Hydroxycamptothecin Doxycyclin Glykolsaeure Hydroxyacetonitril Clindamycin Lincomycin 2-(3,6-Dihydroxy-2,4,5,7-tetrabromxanthen-9-yl)-benzoesure Azithromycin Rapamycin 4-Hydroxybenzaldehyd Hydroxy silicone oil 4-Methoxyphenol
Epothilone B, >=98% Patupilone(Epothilone B) atupilone 4,17-Dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1S,3S,7S,10R,11S,12S,16R)- EPO 906A (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Epothilone B Patupilone ()-Epothilone B,EPO906, EpoB, Patupilone EPO906, EpoB, Patupilone Epothilone B(EPO906) Epothilone B HOUSE STANDARD 152044-54-7 Inhibitors Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds Epothilone B(Patupilone) (3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentaMethyl-3-((E)-1-(2-Methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dione Epothilone B (EPO906, Patupilone) EPOTHILONE (1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione Patupilone (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
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