Ilomastat
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- CAS-Nr.
- 142880-36-2
- Englisch Name:
- Ilomastat
- Synonyma:
- CS-1405;SANTACRUZ;IlloMastat;sc-203979A;galardin tm;Ilomastat, >=98%;GM 6001 Ilomastat;Ilomastat (GM 6001);Galardin
CS 610;IloMastat (GM6001, Galardin)
- CBNumber:
- CB11178927
- Summenformel:
- C20H28N4O4
- Molgewicht:
- 388.46
- MOL-Datei:
- 142880-36-2.mol
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Ilomastat Eigenschaften
- Dichte
- 1.228±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- Soluble in DMSO, and 100% ethanol.
- pka
- 9.16±0.20(Predicted)
- Aggregatzustand
- Off-white solid
- Farbe
- White
- Sensitive
- Moisture Sensitive
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChIKey
- NITYDPDXAAFEIT-DYVFJYSZSA-N
Ilomastat Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
Ilomastat is a metalloprotease inhibitor.
Allgemeine Beschreibung
A cell-permeable, potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). [K
i = 0.4 nM for skin fibroblast collagenase (MMP-1); K
i = 0.5 nM for gelatinase A (MMP-2); K
i = 27 nM for stromelysin (MMP-3); K
i = 0.1 nM for neutrophil collagenase (MMP-8); and K
i = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-α
in vivo and
in vitro and abrogates endotoxin-induced lethality in mice.
Biochem/physiol Actions
GM6001 promotes cardiovascular and hepatocellular function.
Ilomastat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ilomastat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 129)Lieferanten
142880-36-2()Verwandte Suche:
- (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-butanediamide Ilomastat (GM6001, Galardin)
- Galardin
CS 610
- Ilomastat, >=98%
- (r)-n4-hydroxy-n1-[(s)-2-(1h-indol-3-yl)-1-methylcarbamoly-ethyl]-2-isobutyl-succinamide
- galardin tm
- (R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide
- Galardin, GM6001, Ilomastat
- SANTACRUZ
- sc-203979A
- IlloMastat
- (R)-N1-((S)-3-(1H-Indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinami
- IloMastat (GM6001, Galardin)
- (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-butanediamide
- Butanediamide, N4-hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-, (2R)-
- GM 6001 - CAS 142880-36-2 - Calbiochem
- GALARDIN; ILOMASTAT; GM 6001; GM-6001
- GM6001 (galardin, ilomastat)
- CS-1405
- GM 6001 Ilomastat
- Ilomastat (GM 6001)
- (R)-N1-((S)-3-(1H-Indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide
- Ilomastat,GM 6001,inhibit,Matrix metalloproteinases,GM-6001,MMP,Inhibitor
- 142880-36-2
- Inhibitors
