AGM-1470

129298-91-5

CAS-Nr.: 129298-91-5

Englisch Name:: AGM-1470

Synonyma:: Tnp-470;AGM-1470;NSC642492;TNP470,TNP 470;Fumagillin Impurity 1;O-Chloracetyl-carbamoyl fumagillol;O-(chloroacetylcarbamoyl)fumagillol;6-O-chloroacetylcarbamoylfumagillol;TNP-470 - CAS 129298-91-5 - Calbiochem;O-(chloroacetyl-carbaMoyl) fuMagillol,TNP-470

CBNumber:: CB11251062

Summenformel:: C19H28ClNO6

Molgewicht:: 401.88

MOL-Datei:: 129298-91-5.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 57

AGM-1470 Eigenschaften

Schmelzpunkt:: 90-93°C

alpha: D24 -46.6° (c = 0.44 in CHCl3)

Dichte: 1.26±0.1 g/cm3(Predicted)

storage temp.: -20°C

Löslichkeit: DMSO: >15mg/mL

pka: 7.19±0.46(Predicted)

Aggregatzustand: White to light yellow solid

Farbe: White to Pale Yellow Waxy

Stabilität:: Hygroscopic

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26
WGK Germany	2

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizität (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung	src="/GHS07.jpg" width="20" height="20" />

Sicherheit

P261	Einatmen von Staub vermeiden.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

AGM-1470 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

TNP-470 is a synthetic analog of fumagillin that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC₅₀ = 2 μM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis.

Verwenden

TNP-470 is a synthetic analog of fumagillin that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 μM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis.

Definition

ChEBI: A carbamate ester that is fumagillol in which the hydroxy group has been converted to the corresponding N-(chloroacetyl)carbamate derivative.

Allgemeine Beschreibung

TNP-470 is a synthetic analogue of fumagillin. It is a natural product of Aspergillus fumigatus. TNP-470 serves as an angiogenesis inhibitor.

Biologische Aktivität

Analog of Fumagillin ((2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2 -methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5] oct-6-yl] 2,4,6,8-decatetraenedioic acid ester) that displays potent antiangiogenic activity in vitro and in vivo . Inhibits methionine aminopeptidase type II (MetAP2).

AGM-1470 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

AGM-1470 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 57)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 18112977050	cb6@aikonchem.com	China	16687	50
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Hubei Yangxin Medical Technology Co., Ltd.	15374522761	3003392093@qq.com	China	7851	55

129298-91-5()Verwandte Suche:

Thiophanat-methyl Acetylspiramycin Tribenuron methyl 2-[[[[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester Phenyloxiran Ethylenoxid Sineptina Methylacetat Kresoxim-methyl Methylsalicylat Leucomycin V, 3B,9-Diacetat-3,4B-dipropanoat POLYETHYLENE, OXIDIZED Methyl Fumagillin Brommethan Methoxy

NSC642492
O-(chloroacetylcarbamoyl)fumagillol
O-(CHLOROACETYLCARBAMOYL)FUMAGILLOLTNP-470 AGM-1470
[(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] N-(2-chloroacetyl)carbamate
AGM-1470
Carbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[ (2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
Tnp-470
N-(2-Chloroacetyl)carbamicacid(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-ylester
O-(chloroacetyl-carbaMoyl) fuMagillol,TNP-470
(Chloracetyl) carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
O-Chloracetyl-carbamoyl fumagillol
(3R,4S,5S,6R)-5-Methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2
Carbamic acid, N-(2-chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester
TNP-470 - CAS 129298-91-5 - Calbiochem
6-O-chloroacetylcarbamoylfumagillol
TNP470,TNP 470
Fumagillin Impurity 1
129298-91-5
C19H28CINO6