2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

RN 1734 is a novel TRPV4 modulator.

Allgemeine Beschreibung

A cell-permeable benzenesulfonamide compound that acts as a selective TRPV4 antagonist and inhibits TRPV4 agonist 4α-PDD- (Cat. No. 524394) stimulated Ca²⁺ influx (IC₅₀ = 2.3, 3.2 and 5.9 μM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC₅₀ >30 μM).

Biologische Aktivität

Selective TRPV4 antagonist (IC 50 values are 2.3, 5.9 and 3.2 μ M for hTRPV4, mTRPV4 and rTRPV4 receptors respectively). Displays selectivity for over other TRP channels (IC 50 values are 2.3, >30, >30 and >100 μ M for TRPV4, TRPV3, TRPM8 and TRPV1 respectively).

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Syntechem Co.,Ltd		info@syntechem.com	China	12990	57

946387-07-1()Verwandte Suche:

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• 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
• RN 1734
• 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734)
• 2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide
• TRPV4 Antagonist I, RN-1734
• TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem
• 2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide
• Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]-
• RN-1734 (2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide)
• PM-0016
• RN1734,Inhibitor,RN-1734,Transient receptor potential channels,TRP Channel,inhibit,RN 1734
• 946387-07-1