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Fluticasone propionate Produkt Beschreibung

Fluticasone propionate Struktur
80474-14-2
CAS-Nr.
80474-14-2
Englisch Name:
Fluticasone propionate
Synonyma:
Zoflut;flutide;FLUNASE;FLONASE;FLOVENT;cci18781;CUTIVATE;FLIXONASE;FLIXOTIDE;Flutide N
CBNumber:
CB1252206
Summenformel:
C25H31F3O5S
Molgewicht:
500.57
MOL-Datei:
80474-14-2.mol

Fluticasone propionate Eigenschaften

Schmelzpunkt:
275 °C
alpha 
D +30° (c = 0.35)
Brechungsindex
31 ° (C=1, Dioxane)
storage temp. 
Store at RT
Löslichkeit
DMSO: ≥10 mg/mL
Aggregatzustand
solid
Farbe
white
Merck 
14,4211
InChIKey
WMWTYOKRWGGJOA-CENSZEJFSA-N
CAS Datenbank
80474-14-2(CAS DataBase Reference)

Sicherheit

S-Sätze: 22-24/25
WGK Germany  2
RTECS-Nr. BV7980000
HS Code  29372900

Fluticasone propionate Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Fluticasone propionate is a new glucocorticosteroid useful in the treatment of seasonal rhinitis and asthma. Compared to beclomethasone dipropionate, fluticasone propionate is reported to have a comparable side effect profile, but twice the activity in the treatment of asthma.

Chemische Eigenschaften

Crystalline Solid

Originator

Glaxo (United Kingdom)

Verwenden

An antiallergic and anti inflammatory

Verwenden

A derivative of Flumethasone. An antiallergic; anti-asthmatic; anti-inflammatory.

Verwenden

antiviral

Verwenden

Atorvastatin Intermediate

Verwenden

A high-affinity, selective glucocorticoid receptor agonist

Definition

ChEBI: A trifluorinated corticosteroid that consits of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a propionyl s bstituent at position 17; has anti-inflammatory, anti-asthmatic and anti-allergic activity.

Trademarks

Cutivate (Altana); Flonase (GlaxoSmithKline); Flovent (GlaxoSmithKline);Flixonase.

Allgemeine Beschreibung

Fluticasone propionate,S-(fluoromethyl) 6α,9-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(1-oxopropoxy)androsta-1,4-diene-17-carbothio-ate (Cutivate), is threefold to fivefold more potentthan dexamethasone in receptor binding assays.

Allgemeine Beschreibung

The main metabolite of fluticasonepropionate (Flovent, Flonase) found in circulationin humans is the 17β-carboxylate derivative. As expected,a charged carboxylate in place of the normal acetol functionalityat C17 greatly reduces affinity for the GR (2,000-fold less than the parent), and this metabolite is essentiallyinactive. The metabolite is formed via the CYP3A4 system,so care should be taken if fluticasone propionate iscoadministered with a CYP3A4 inhibitor such as ketoconazoleor ritonavir. Clinically induced Cushing syndromehas been observed when inhaled fluticasone propionatewas administered concurrently with ritonavir.Fluticasone is also available in an inhaled formulation incombination with the long-acting β2-agonist salmeterol(Advair Diskus).

Biologische Aktivität

High affinity, selective glucocorticoid receptor agonist (K d = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC 50 = 3.7 nM) in vitro . Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic, clinically-used anti-inflammatory agent with low oral bioavailability.

Veterinary Drugs and Treatments

While there are topical forms of fluticasone, most veterinary interests are in the inhaled versions of the drug. The aerosol for pulmonary inhalation appears to be effective in treating feline asthma, recurrent airway obstruction (RAO, heaves) or inflammatory airway disease (IAD) in horses, and dogs with chronic tracheobronchial disease. While the majority of small animal use has been with fluticasone, there are several other aerosol corticosteroids for inhalation (beclomethasone dipropionate, flunisolide, and triamcinolone acetonide) that theoretically could be used for the same purpose. The nasal inhalation corticosteroid products may be useful for allergyrelated chronic rhinosinusitis in cats and dogs.

Fluticasone propionate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Fluticasone propionate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 292)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21676 58
Chengdu Henghui Pharm Tec Co. Ltd.
13540674322 15828370308,QQ:2879822141
028-89481236 service@2hpharm.com CHINA 121 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 535 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 296 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58

80474-14-2()Verwandte Suche:


  • Fluticasone propionate - micronised pharma grade
  • androsta-1,4-diene-17-carbothioicacid,6,9-difluoro-11-hydroxy-16-methyl-3-oxo
  • cci18781
  • fluticasone17-propionate
  • flutide
  • (6A,11B,16A,17A)-6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)ANDROSTA-1,4-DIENE-17-CARBOTHIOIC ACID FLUOROMETHYL ESTER
  • (6 ALPHA,11 BETA,16 ALPHA,17 ALPHA)-6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)ANDROSTA-1,4-DIENE-17-CARBOTHIOIC ACID FLUOROMETHYL ESTER
  • (6ALPHA, 11BETA, 16ALPHA, 17ALPHA)-6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)ANDROSTA-1,4-DIENE-17-CARBOTHIOIC ACID S-(FLUOROMETHYL) ESTER
  • CCI-187881
  • CUTIVATE
  • FLUTICASONE-D5 PROPIONATE
  • FLUTICASONE PROPIONATE
  • FLUNASE
  • FLONASE
  • FLIXONASE
  • FLIXOTIDE
  • FLOVENT
  • Fluticasone Propionate - C25H31F3O5S
  • Fluticasonepropiponate
  • CCI-187881, Cutivate, Flixonase, Flixotide, Flonaase, Flovent, Flunase
  • Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, S-(fluoromethyl) ester, (6.alpha.,11.beta.,16.alpha.,17.alpha.)-
  • [(6S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
  • Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, S-(fluoromethyl) ester, (6α,11β,16α,17α)-
  • Atemur Mite
  • Cutivate cream
  • Flixonase Nasal Spray
  • Flixotide Disk
  • Flixotide Disks
  • Flixotide Inhaler
  • Flonase Aq
  • Flovent Diskus
  • Flutide N
  • Flutivate
  • Zoflut
  • FLUTICASOUE PROPIONATE
  • (6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester
  • (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester
  • S-fluoromethyl 6a,9a-difluoro-l l P-hydroxy-16 a- methyl-l7a-propionyloxy-3-oxoandrosta-l,4-diene-17~-carbothioat
  • (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluommethyl)ester
  • (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioicacidfluoromethylester
  • Fluticasone Propionate (100 mg)
  • Fluticasone propiona
  • luticasone-d5 propionate
  • Fluticasone propionate (Flonase, VeraMyst)
  • (6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-Methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-c
  • CARBOTHIOIC ACID FLUOROMETHYL ESTER
  • Fluticasone Furoate API
  • (6α,11β,16α,17α)-androsta-1,4-diene-17-carbothioic acid-6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-S-(fluoromethyl) ester
  • Fluticasone propionate S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate
  • Fluticasone propionate Solution, 100ppm
  • Fluticasone Propimonate
  • 80474-14-2
  • Fluticasone propiote
  • Fluticasone propionate for impurity G identification
  • Fluticasone propionate for impurity C identification
  • S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate
  • Fluticasone Propinate
  • 6α,9-Difluoro-17-[[(fluoromethyl)sulphanyl]carbonyl]-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-dien-17α-yl propanoate
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