Metoclopramide hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Metoclopramide Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and biological fluids by chromatography and chemiluminescence techniques.
Indications
Metoclopramide (Reglan) stimulates upper GI tract
motility and has both central and peripheral actions.
Centrally, it is a dopamine antagonist, an action that is
important both for its often desirable antiemetic effect
and other less desirable effects. Peripherally, it stimulates
the release of intrinsic postganglionic stores of
acetylcholine and sensitizes the gastric smooth muscle
to muscarinic stimulation. The ability of metoclopramide
to antagonize the inhibitory neurotransmitter
effect of dopamine on the GI tract results in increased
gastric contraction and enhanced gastric emptying and
small bowel transit.
Definition
ChEBI: A hydrate that is the monohydrate form of metoclopramide monohydrochloride.
Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Metoclopramide Hydrochloride is an antiemetic drug and is generally used for the treatment of gastrointestinal disorders. It can also exhibit sedative, extrapyrimidal, and prolactin secretion stimulation actions.
Mechanism of action
Metoclopramide is rapidly absorbed following an
oral dose in a patient with intact gastric emptying. Peak
plasma concentration is achieved within 40 to 120 minutes.
With normal renal function, plasma half-life is
about 4 hours.About 20% of an oral dose is eliminated
unchanged in the urine, while 60% is eliminated as sulfate
or glucuronide conjugates.
Clinical Use
Improved gastric emptying will frequently alleviate
symptoms in patients with diabetic, postoperative, or idiopathic
gastroparesis. Since metoclopramide also can
decrease the acid reflux into the esophagus that results
from slowed gastric emptying or lower esophageal
sphincter pressure, the drug can be used as an adjunct in
the treatment of reflux esophagitis.
Nebenwirkungen
Side effects include fatigue, insomnia, and altered motor
coordination. Parkinsonian side effects and acute dystonic
reactions also have been reported. Metoclopramide
stimulates prolactin secretion, which can cause galactorrhea
and menstrual disorders. Extrapyramidal side effects
seen following administration of the phenothiazines,
thioxanthenes, and butyrophenones may be accentuated
by metoclopramide.
Metoclopramide hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
