Progabid
|
|
|
- CAS-Nr.
- 62666-20-0
- Bezeichnung:
- Progabid
- Englisch Name:
- Progabide
- Synonyma:
- Gabren;Gabrene;SL-76．002;progabide;Halogabide;C-abren(e);Progabide USP/EP/BP;4-[α-(p-Chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino]butyramide;4-[[(4-Chlorophenyl)(5-fluoro-2hydroxyphenyl)methylene]amino]butanamide;(E)-4-((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyleneamino)butanamide
- CBNumber:
- CB1296044
- Summenformel:
- C17H16ClFN2O2
- Molgewicht:
- 334.77
- MOL-Datei:
- 62666-20-0.mol
|
Progabid Eigenschaften
- Schmelzpunkt:
- 133-135°; mp 142.5° (Kaplan, J. Med. Chem.)
- Siedepunkt:
- 525.4±50.0 °C(Predicted)
- Dichte
- 1.2822 (estimate)
- storage temp.
- 2-8°C
- Löslichkeit
- Chloroform (Slightly, Sonicated), DMSO, Methanol (Slightly, Sonicated)
- Aggregatzustand
- Solid
- pka
- pKa 3.41 ± 0.04(0.4% MeOH,t=37,Iundefined)(Approximate)
- Farbe
- Light Yellow to Yellow
- Wasserlöslichkeit
- 37.16mg/L(37 ºC)
- CAS Datenbank
- 62666-20-0
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Toxizität |
LD50 i.p. in mice: 900 mg/kg (Kaplan) |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
|
|
| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
|
Progabid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Progabide is a broad-spectrum anticonvulsant agent indicated for the treatment of
a wide variety of seizure disorders. Synthesized as a GABA-prodrug, anticonvulsant
activity appears due to the parent drug and its acid metabolite, as
well as to GABAmide and GABA liberated therefrom.
Chemische Eigenschaften
Bright Yellow Solid
Verwenden
Progabide is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity.
Weltgesundheitsorganisation (WHO)
Progabide, an anticonvulsant, was introduced in France in 1985
for the treatment of epilepsy. Its use has occasionally been associated with
clinically evident signs of icteric hepatitis developing within the first six months of
treatment. These signs are generally reversible on withdrawal of the drug but
continuation of treatment has been associated with three reported fatalities (two of
which are doubtfully related to the drug). The manufacturer revised the data sheet
in March 1986 advising that use of progabide should be reserved for patients
unresponsive to other anticonvulsants.
Progabid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Progabid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 49)Lieferanten
62666-20-0(Progabid)Verwandte Suche:
- progabide
- BUTANAMIDE, 4-[[(4-CHLOROPHENYL)(5-FLUORO-2-HYDROXYPHENYL)METHYLENE]AMINO]-
- Halogabide
- (E)-4-((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyleneamino)butanamide
- 4-[[(Z)-(4-Chlorophenyl)-(3-fluoro-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]butanamide
- 4-[[(4-Chlorophenyl)(5-fluoro-2hydroxyphenyl)methylene]amino]butanamide
- C-abren(e)
- SL-76．002
- 4-[α-(p-Chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino]butyramide
- Gabren
- Gabrene
- Progabide USP/EP/BP
- 62666-20-0
- C17H16ClFN2O2
- Amines
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
