Teicoplanin

Teicoplanin Struktur
61036-62-2
CAS-Nr.
61036-62-2
Englisch Name:
Teicoplanin
Synonyma:
TEIC;8327a;Tagocid;18-[(3AS;Ticoplanin;Teicalnine;Telcoplanin;TEICOPLANIN;Teocoplanin;teichomycin
CBNumber:
CB1308141
Summenformel:
C78H77Cl2N8O32R
Molgewicht:
1709.39
MOL-Datei:
61036-62-2.mol

Teicoplanin Eigenschaften

Schmelzpunkt:
310 °C (decomp)
RTECS-Nr.
WY1559000
storage temp. 
2-8°C
Löslichkeit
H2O: soluble10mg/mL
Aggregatzustand
powder
Farbe
white to faint yellow
Wasserlöslichkeit
Sparingly soluble in water
CAS Datenbank
61036-62-2
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
WGK Germany  3
HS Code  2941900000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Teicoplanin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Teicoplanin is a new antibiotic, the second glycopeptide to be developed in over 30 years. Compared with vancomycin, the only such agent currently available, teicoplanin is equiefficacious, and has milder side-effects and a longer half-life, allowing once-daily dosing and bolus injection. Teicoplanin is claimed to have an overall cure rate of 92% in infections involving skin, joint and bone, endocaditis and septicemia.

Chemische Eigenschaften

Yellowish, amorphous powder.

Verwenden

Teicoplanin complex is family of closely related metabolites produced by Actinoplanes teichomyceticus. Teicoplanin complex possesses potent broad spectrum antibiotic activity against Gram positive bacteria, including MRSA and E. faecalis. The metabolites share a common glycopeptide core (teicoplanin A-3) on which a family of fatty acids varying in length, degree of saturation and branching are linked as amides through one of the aminoglycoside moieties. The major component of the complex is teicoplanin A2 which itself has five major components (teicoplanin A2-1 to A2-5) and four minor components (teicoplanin RS-1 to RS-4).

Allgemeine Beschreibung

Teicoplanin (Teichomycin A2, Targocid) is a mixture offive closely related glycopeptide antibiotics produced bythe actinomycete Actinoplanes teichomyceticus. The teicoplanin factors differ only in the acyl group inthe northernmost of two glucosamines glycosidicallylinked to the cyclic peptide aglycone. Another sugar, Dmannose,is common to all of the teicoplanins. Thestructures of the teicoplanin factors were determined independentlyby a combination of chemical degradationand spectroscopic methods in three different groupsin 1984.
The teicoplanin complex is similar to vancomycin structurallyand microbiologically but has unique physical propertiesthat contribute some potentially useful advantages.While retaining excellent water solubility, teicoplanin has significantlygreater lipid solubility than vancomycin. Thus, teicoplaninis distributed rapidly into tissues and penetratesphagocytes well. The complex has a long elimination halflife,ranging from 40 to 70 hours, resulting from a combinationof slow tissue release and a high fraction of protein bindingin the plasma (~90%). Unlike vancomycin, teicoplanin isnot irritating to tissues and may be administered by intramuscularor intravenous injection. Because of its long half-life, teicoplaninmay be administered on a once-a-day dosing schedule.Orally administered teicoplanin is not absorbedsignificantly and is recovered 40% unchanged in the feces.
Teicoplanin exhibits excellent antibacterial activity againstGram-positive organisms, including staphylococci, streptococci,enterococci, Clostridium and Corynebacterium spp.,Propionibacterium acnes, and L. monocytogenes. It is not activeagainst Gram-negative organisms, including Neisseriaand Mycobacterium spp. Teicoplanin impairs bacterial cellwall synthesis by complexing with the terminal D-alanine-Dalaninedipeptide of the peptidoglycan, thus preventing crosslinkingin a manner entirely analogous to the action ofvancomycin.

Teicoplanin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Teicoplanin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 386)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+8613288715578
sales@hbmojin.com China 12456 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 7786 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806
sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21691 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
bruce@xrdchem.cn CHINA 566 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282
alice@crovellbio.com China 8823 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 906 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845
sales@amoychem.com China 6387 58

61036-62-2()Verwandte Suche:


  • Ticoplanin
  • Telcoplanin
  • Teicoplanin Complex (Tecoplanin)
  • TEICOPLANIN
  • 8327a
  • antibiotic8327a
  • teichomycin
  • TEICOPLANIN(PATENTED)
  • Teocoplanin
  • Telicoplanin
  • TEICOPLANIN, JP
  • TeicoplaninSodium
  • Telcoplanin,Tecoplanin
  • Tagocid
  • Teicoplanin sterile
  • lyophilised teicoplanin
  • TazobactuM SodiuM+Piperacillin SodiuM
  • TeichoMycin, Tecoplanin, Targocid, TeicoMid, 8327A, DL 507IT, L 12507, MDL 507, MW 1900
  • Teicoplanin coMplex
  • TEICOPLANIN [A(2-1) shown]
  • Antibiotic MDL-507
  • Teicoplanin for identification CRS
  • Teicoplanin CRS
  • Teicoplanin USP/EP/BP
  • Teicoplanin Complex Please see T015500
  • TeicoplaninQ: What is Teicoplanin Q: What is the CAS Number of Teicoplanin Q: What is the storage condition of Teicoplanin Q: What are the applications of Teicoplanin
  • 18-[(3AS
  • Teicomycin,、Targocid
  • TEIC
  • Teicoplanin (9CI, ACI)
  • Teicalnine
  • 61036-62-2
  • 616036-62-2
  • C78H77Cl2N8O32R
  • C89H99Cl2N9O29
  • C77H77N9O31Cl2R
  • Active Pharmaceutical Ingredients
  • API
  • HYAMATE
  • 61036-62-2
Copyright 2019 © ChemicalBook. All rights reserved