Colistimethatnatrium
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- CAS-Nr.
- 8068-28-8
- Bezeichnung:
- Colistimethatnatrium
- Englisch Name:
- Colistin sodium methanesulfonate
- Synonyma:
- Colistin Methanesulfonate;Colistimethate sodium CRS;COLISTIN SODIUM METHANESULFONATE;w1929;Promixi;colistinat;colimycinm;colymycinm;Coly-mycin M (TN);colistinsulfomethat
- CBNumber:
- CB1371673
- Summenformel:
- Unspecified
- Molgewicht:
- 1749.82
- MOL-Datei:
- 8068-28-8.mol
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Colistimethatnatrium Eigenschaften
- Schmelzpunkt:
- >228°C (dec.)
- storage temp.
- 2-8°C
- Löslichkeit
- H2O: soluble10mg/mL
- Aggregatzustand
- powder
- Farbe
- white to faintly beige
- PH
- 6-8 (10mg/mL in H2O)
- Wasserlöslichkeit
- Freely soluble in water
- Merck
- 13,2503
- CAS Datenbank
- 8068-28-8
- EPA chemische Informationen
- Colistimethate sodium (8068-28-8)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| RIDADR |
3249 |
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| WGK Germany |
2 |
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| RTECS-Nr. |
GH1650000 |
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| F |
3 |
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| TSCA |
Yes |
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| HazardClass |
6.1(b) |
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| PackingGroup |
III |
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| HS Code |
2941906000 |
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| Toxizität |
LD50 i.v. in mice: >550 mg/kg (Barnett) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H361 |
Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. |
Reproduktionstoxizität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
| H362 |
Kann Säuglinge über die Muttermilch schädigen. |
Reproductive toxicity, effects on or via lactation |
Additional category |
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P201, P260, P263, P264, P270,P308+P313 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P263 |
Kontakt während der Schwangerschaft /und der Stillzeit vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P281 |
Vorgeschriebene persönliche Schutzausrüstung verwenden. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Colistimethatnatrium Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White or almost white, hygroscopic powder.
Definition
ChEBI: A mixture where R = H or Me. Colistin in which each of the primary amino groups is converted to the corresponding aminomethanesulfonic acid sodium salt, commonly by the action of formaldehyde followed by sodium bisulfite. A polymyxin antibiotic derivative,
it is used in the treatment of severe infections, particularly of multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii.
Pharmakokinetik
Colistin is administered intravenously as the non-active prodrug, colistin methanesulfonate sodium (CMS). Colistin methanesulfonate sodium (Colistin sodium methanesulfonate) is eliminated mainly by renal clearance. If CMS is cleared rapidly by the kidney, less CMS is converted to colistin resulted in low colistin that could lead to ineffective antibacterial therapy. In patients with normal renal function (1–2 MIU of CMS), approximately 30–60% of a dose of CMS is converted to colistin. The renal clearance of CMS is much more efficient than the conversion of CMS to colistin. Therefore, to achieve a targeted concentration of >2 mg/L, patients must receive four to five times the amount of CMS. There was wide variability of colistin Cmax values (0.6–8.7 mg/L) in plasma among single-dose studies receiving 2–3 MIU of CMS in critically ill patients with preserved renal function. Almost none of the ICU patients achieved a colistin concentration of more than 2 mg/L in the Plachouras et al. and Mohamed et al. studies[4].
Sicherheitsprofil
Human poison by intramuscular route. Experimental poison by intramuscular, intraperitoneal, subcutaneous, and intravenous routes. Mildly toxic by ingestion. An experimental teratogen. Human systemic effects by intramuscular route: convulsions or effect on seizure threshold, change in motor activity, change in lrldney tubules, and urine volume decrease or anuria. Experimental reproductive effects. Used as an antibiotic. When heated to decomposition it emits very toxic fumes of NOx, SOx, and NazO
Colistimethatnatrium Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Colistimethatnatrium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 149)Lieferanten
8068-28-8(Colistimethatnatrium)Verwandte Suche:
Natrium-(±)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-methansulfonat
Methansulfonsure
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')dysprosium
Aluminiumtris(2,4-pentandionato-O,O')
2-Methylpropylisocyanid
(p-Toluolsulfonyl)methylisocyanid
N-Butylisocyanid
Phenylselenol
Kupfer(II)-4-oxopent-2-en-2-olat
Tris(pentan-2,4-dionato)eisen(II)
(Pentan-2,4-dionato-O,O')silber
(Ethylenbis(nitrilomethylidyn)-2,2'-diphenolato)cobalt(II)
1,1,3,3-Tetramethylbutylisocyanat
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')europium
Methylisocyanacetat
Colistin
Benzylisocyanid
Ethylisocyanacetat
- COLIMYCIN SODIUM METHANESULFONATE
- COLISTIN METHANESULFONATE SODIUM SALT
- (METHANESULFONIC ACID DERIVATIVE OF POLYMYXIN E) SODIUM SALT
- POLYMYXIN E SODIUM METHANESULFONATE
- colimycinm
- colistinat
- colistinmethanesulfonicacid,sodiumsalt
- colistinsulfomethat
- colistinsulfomethate
- colistinsulfomethatesodium
- colistrimethatesodium
- coly-mycininjectable
- colymycinm
- coly-mycinmparenteral
- pentasodiumcolistinmethanesulfonate
- sodiumcolistimethate
- sodiumcolistinemethanesulfonate
- sodiumcolistinmethanesulfonate
- w1929
- COLISTIN METHANESULFONATE SODIUM
- COLISTIN SODIUM METHANESULFONATE FROM BA CILLUS COLISTINUS
- ColistimethaleSodium
- COLISTINSULPHOMETHATESODIUM
- Coly-mycin M (TN)
- COLISTIN METHANESULFATE SODIUM USP
- Colimycin sodium methanesulfonate, Methanesulfonic acid derivative of Polymyxin E, Polymyxin E sodium methanesulfonate
- colistinmethanesulfonicacid,sod
- pentasodium [[4-[[2-hydroxy-1-[[1-[[19-(1-hydroxyethyl)-7,10-diisobutyl-2,5,8,11,14,17,20-heptaketo-4,13,16-tris[2-(sulfonatomethylamino)ethyl]-3,6,9,12,15,18,21-heptazacyclotricos-1-yl]carbamoyl]-3-(sulfonatomethylamino)propyl]carbamoyl]propyl]amino]-4-keto-3-(6-methyloctanoylamino)butyl]amino]methanesulfonate
- pentasodium [[4-[[3-hydroxy-1-[[1-[[19-(1-hydroxyethyl)-7,10-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-4,13,16-tris[2-(sulfonatomethylamino)ethyl]-3,6,9,12,15,18,21-heptazacyclotricos-1-yl]amino]-1-oxo-4-(sulfonatomethylamino)butan-2-yl]amino]-1-oxo-butan-2-yl]amino]-3-(6-methyloctanoylamino)-4-oxo-butyl]amino]methanesulfonate
- pentasodium [[4-[[3-hydroxy-1-[[1-[[19-(1-hydroxyethyl)-7,10-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-4,13,16-tris[2-(sulfonatomethylamino)ethyl]-3,6,9,12,15,18,21-heptazacyclotricos-1-yl]amino]-1-oxo-4-(sulfonatomethylamino)butan-2-yl]amino]-1-oxobutan-2-yl]amino]-3-(6-methyloctanoylamino)-4-oxobutyl]amino]methanesulfonate
- ColistiMethate SodiuM, USP
- Colistimethate Sodium (200 mg)
- Promixi
- Colistin, methyl sulfate, sodium salt
- Methanesulfonic acid derivative of Polymyxin E
- E1 Colistimethate sodium for peak identification
- Sodium Colistin Methanesulfonate (Technical Grade)
- Colistimethate sodium for peak identification (Y0001888)
- Colistimethate sodiumQ: What is
Colistimethate sodium Q: What is the CAS Number of
Colistimethate sodium Q: What is the storage condition of
Colistimethate sodium Q: What are the applications of
Colistimethate sodium
- Colistimethate Sodium (1147009)
- COLISTIN SODIUM METHANESULFONATE
- Colistin Methanesulfonate
- Colistimethate sodium CRS
- 3a,6-Dimethyl-3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione
- colistimethatesodiumispreparedfromcolistinbytheactionofformaldehydeandsodiumhydrogensulfitetoformamixtureofditopentabis-sulfomethylatedprimaryaminederivatives,mainlypolymyxinse1ande2.
Semi-syntheticproductderivedfromafermentationproduct
- 8068-28-8
- C58H115N16Na5O28S5
- C57H102N16Na5O28S5R
- C58H105N16O28S5Na5
- C58H105N16Na5O25S5
- C58H105N16O28S55Na
- Antibiotics
- Antibiotics A-F
- Antibiotics A to Z
- BioChemical
- COLOMYCIN
