2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
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- CAS-Nr.
- 729589-58-6
- Englisch Name:
- 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
- Synonyma:
- 2fLI;2-Fly;f-LIGRLO-NH2;2-f-LIGRLO-NH2;2F-LIGRLO-AMIDE;PAR-2 AGONIST II;2-Furoyl-LIGRLO-NH2;2-Furoyl-LIGRLO-amid;2-FUROYL-LIGRLO-AMIDE;2-(2-FUROYL)-LIGRLOAMIDE
- CBNumber:
- CB1382037
- Summenformel:
- C36H63N11O8
- Molgewicht:
- 777.95
- MOL-Datei:
- 729589-58-6.mol
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2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Eigenschaften
- Dichte
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- Löslichkeit
- Soluble in H2O
- Aggregatzustand
- powder
- pka
- 12.91±0.46(Predicted)
- Farbe
- white
- Wasserlöslichkeit
- Soluble to 1 mg/ml in water
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi |
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| R-Sätze: |
36/37/38 |
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| S-Sätze: |
26 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten Räumen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
2-Furoyl-LIGRLO-amide trifluoroacetate salt may be used as a protease-activated receptor 2 (PAR2) agonist in endothelial progenitor cells (EPCs) and in transient receptor potential cation channel subfamily V member (TRPV4)-transfected HEK293t cells.
Allgemeine Beschreibung
2-Furoyl-LIGRLO-amide trifluoroacetate salt is a peptide that acts as a proteinase-activated receptor-2 (PAR
2) agonist, and contains a furoyl group addition at its N-terminal.
Biochem/physiol Actions
2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist. PAR-2 activation is associated with increases in cAMP and intracellular Ca(2+). Immunoblot analysis revealed increases in phosphorylation of epidermal growth factor (EGF) receptor (EGFR) tyrosine kinase, Src, Pyk2, cRaf, and ERK1/2 in response to PAR-2 activation. 2-Furoyl-LIGRLO-amide is nearly 100-fold more potent than SLIGRL-NH2 (Cat. No. S9317). 2-Furoyl-LIGRLO-amide caused both an endothelium-dependent relaxation and an endothelium-independent contraction. It produced delayed (6 hours later) facilitation of capsaicin-evoked visceral nociception, an effect being much more potent than SLIGRL-NH2. Such effects were mimicked by i.col. trypsin. 2-f-LIGRL-NH2, coadministered repeatedly with caerulein six times in total, abolished the caerulein-evoked abdominal hyperalgesia/allodynia in WT, but not PAR2-KO, mice. Repeated doses of 2-f-LIGRL-NH2 moderately attenuated the severity of caerulein-induced pancreatitis in WT animals. It induced a similar dose-dependent increase in Ca2 levels in the presence and absence of b-arrestins.
2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 67)Lieferanten
- PAR-2 AGONIST II
- PROTEINASE ACTIVATED RECEPTOR-2 AGONIST II
- 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
- 2-(2-FUROYL)-LIGRLOAMIDE
- 2-(2-FUROYL)-PAR-2 (2-6)-ORN AMIDE (MOUSE, RAT)
- 2F-LIGRLO-AMIDE
- 2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2
- 2-FUROYL-LIGRLO-AMIDE
- (2-Furoyl)-PAR-2 (2-6)-Orn amide (mouse, rat)
- 2fLI
- 2-f-LIGRLO-NH2
- 2-Fly
- 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt
- 2-Furoyl-LIGRLO-amide trifluoroacetate salt
- f-LIGRLO-NH2
- 2-Furoyl-LIGRLO-NH2 Potent and Selective Protease-Activated Receptor 2 (PAR2) Agonist
- L-Ornithinamide, N-(2-furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucyl-
- N-(2-Furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucyl-L-ornithinamide
- 2-Furoyl-LIGRLO-amid
- 2-Furoyl-LIGRLO-NH2
- Potent and Selective Protease-Activated Receptor2 (PAR2) Agonist
- 729589-58-6
- C36H63N11O8
