KENPAULLONE

KENPAULLONE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

Tan Solid

Verwenden

The paullones are a novel class of kinase inhibitors, initially identified as CDK inhibitors. Kenpaullone has been found to be a useful GSK-3?inhibitor (IC50=23nM).

Allgemeine Beschreibung

A potent, cell-permeable, and reversible inhibitor of glycogen synthase kinase-3β (IC₅₀ = 230 nM), Lck (IC₅₀ = 470 nM), and cyclin-dependent kinases (Cdks). Inhibits Cdk1/cyclin B (IC₅₀ = 400 nM), Cdk2/cyclin A (IC₅₀ = 680 nM), Cdk2/cyclin E (IC₅₀ = 7.5 μM), and Cdk5/p25 (IC₅₀ = 850 nM). Also inhibits other kinases such as c-Src (IC₅₀ = 15 μM), casein kinase II (IC₅₀ = 20 μM), ERK1 (IC₅₀ = 20 μM), and ERK2 (IC₅₀ = 9 μM). Inhibition is competitive with respect to ATP binding.

Biologische Aktivität

Potent inhibitor of CDK1/cyclin B and GSK-3 β (IC 50 values are 0.4 and 0.23 μ M respectively). Also inhibits CDK2/cyclin A, CDK2/cyclin E and CDK5/cyclin/p35 (IC 50 values are 0.68, 7.5 and 0.85 μ M respectively). Selective over c-src (IC 50 = 15 μ M), casein kinase 2 (IC 50 = 20 μ M), ERK1 (IC 50 = 20 μ M), ERK2 (IC 50 = 9 μ M) and a range of other protein kinases (IC 50 values > 35 μ M). Generates induced pluripotent stem cells (iPSCs) from somatic cells when used in combination with reprogramming factors; can replace Klf4.

KENPAULLONE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

KENPAULLONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12468	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58

142273-20-9()Verwandte Suche:

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• 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one, NSC 664704
• 9-BroMopaullone
• Kenpaullon
• 9-BROMO-7,12-DIHYDRO-INDOLO[3,2-D][1]BENZAZEPIN-6(5H)-ONE
• 8-BROMO-7,12-DIHYDRO-INDOLO[3,2-D][1]-BENZAZEPIN-6(5H)-ONE
• KENPAULLONE
• NSC-664704
• Kenpaullone 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
• 9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one
• 9-Bromo-7,12-dihydrobenzo[2,3]azepino[4,5-b]indol-6(5H)-one
• Kenpaullone (NSC-664704)
• NSC664704;NSC 664704
• Kenpaullone - CAS 142273-20-9 - Calbiochem
• CS-498
• NSC-664704(Kenpaullone)
• NSC664704;NSC 664704;9-BROMOPAULLONE
• Kenpaullone Kenpaullone
• Kenpaullone>
• KenpauL
• Indolo[3,2-d][1]benzazepin-6(5H)-one, 9-bromo-7,12-dihydro-
• 142273-20-9
• 142273-29-9
• C16H11BrN2O
• Cell Biology
• Cell Signaling and Neuroscience
• Cell Cycle
• Cell Cycle Regulators
• Apoptosis and Cell Cycle
• BioChemical
• All Inhibitors
• Inhibitors
• Aromatics
• Heterocycles
• Intermediates & Fine Chemicals
• Pharmaceuticals
• Protein Kinase