Meglutol
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- CAS-Nr.
- 503-49-1
- Bezeichnung:
- Meglutol
- Englisch Name:
- 3-HYDROXY-3-METHYLGLUTARIC ACID
- Synonyma:
- Meglutol;3-Hydroxymethylglutaric acid;3-HYDROXY-3-METHYLPENTANEDIOIC ACID;lipoglutaren;DICROTALIC ACID;hmga;cb-337;AKOS 91366;medroglutaricacid;3-HYDROXY-3-METHYLPENTANE-1
- CBNumber:
- CB1454369
- Summenformel:
- C6H10O5
- Molgewicht:
- 162.14
- MOL-Datei:
- 503-49-1.mol
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Meglutol Eigenschaften
- Schmelzpunkt:
- 105-108 °C (lit.)
- Siedepunkt:
- 120 °C / 13mmHg
- Dichte
- 1.2132 (rough estimate)
- Brechungsindex
- 1.4230 (estimate)
- storage temp.
- -20°C
- Löslichkeit
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 10 mg/ml
- Aggregatzustand
- powder to crystal
- pka
- 3.95±0.10(Predicted)
- Farbe
- White to Light yellow
- Merck
- 14,5808
- BRN
- 1769194
- CAS Datenbank
- 503-49-1(CAS DataBase Reference)
Meglutol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Meglutol (β-hydroxy-β-methylglutaric acid; HMG) is a hypolipidemic agent that
acts via the inhibition of cholesterol synthesis a t the stage of HMG-CoAreductase,
blocking the conversion of HMG-CoA to mevalonate. This conversion
is the rate-limiting step in cholesterol biosynthesis and is the point of
physiological feedback control; as such, it appears to be the ideal locus of action
for a hypolipidemic agent. Investigational compounds that act by this mechanism
include the natural products compactin and mevinolin.
Chemische Eigenschaften
White Solid
Verwenden
antihyperlipoproteinemia
Definition
ChEBI: A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase
(3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.
läuterung methode
Recrystallise the acid from diethyl ether/hexane and dry it under avacuum at 60o for 1hour. [Beilstein 3 IV 1166.]
Meglutol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Meglutol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 113)Lieferanten
503-49-1(Meglutol)Verwandte Suche:
- hmga
- medroglutaricacid
- 3-HYDROXY-3-METHYLPENTANEDIOIC ACID (HMG)
- 3-Hydroxy-3-methylglutaric acid ,98%
- 3-Hydroxy-3-Methylglutaric acid >=95%
- 3-HYDROXY-3-METHYLGLUTARIC ACID
- AKOS 91366
- B-METHYL-B-HYDROXYGLUTARIC ACID
- B-HYDROXY-B-METHYLGLUTARIC ACID
- 3-hydroxy-3-methyl-glutaricaci
- beta-hydroxy-beta-methylglutaricacid
- cb-337
- 3-Hydroxy-3-methylglutaricAcid>
- 3-HYDROXY-3-METHYLPENTANE-1
- Pentanedioic acid, 3-hydroxy-3-methyl-
- 3-HYDROXY-3-METHYLGLUTARIC ACID USP/EP/BP
- 3-Hydroxy-3-methylpentanedioic acid[Dicrotalic Acid
- 3-Hydroxy-3-methyl-pentanedioic acid, 98+%
- lipoglutaren
- 3-Hydroxymethylglutaric acid
- Meglutol
- 3-HYDROXY-3-METHYLPENTANEDIOIC ACID
- DICROTALIC ACID
- Autophagy,inhibit,Meglutol,Endogenous Metabolite,Inhibitor,HMG-CoA Reductase (HMGCR)
- Adipic acid impurity3（Meglutto）
- 503-49-1
- 1461426
- HOCCH3CH2CO2H2
- Organic Building Blocks
- C6
- Carboxylic Acids
- Carbonyl Compounds
- Building Blocks
- Miscellaneous Reagents
- Building Blocks
- C6
- Carbonyl Compounds
- Carboxylic Acids
- Chemical Synthesis
- Organic Building Blocks
- Pharmaceutical Raw Materials
