2-(2,2-Dicyclohexylethyl)piperidiniumhydrogenmaleat Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug in the 1970s. It inhibits rat heart and liver CPT1 (IC
50 = 77 and 148 μM, respectively) and rat heart CPT2 (IC
50 = 79 μM). Inhibition of CPT reduces uptake of long-chain fatty acids into the mitochondria, thereby shifting cellular metabolism from β-oxidation to glycolysis. Perhexilin inhibits mTORC1 signaling at 10 μM and induces autophagy ~7-fold at a concentration of 10 μM in MCF-7 cells.
Chemische Eigenschaften
White Solid
Verwenden
PERHEXILINE MALEATE SALT is a Vasodilator, used in treatments for angina.
Allgemeine Beschreibung
Perhexiline maleate regulates?coronary vasodilatation and blocks exercise-induced tachycardia. It is used to treat angina pectoris and variant angina. Perhexiline maleate functions as a cardiac metabolic agent. It is associated with peripheral neuropathy, high intracranial pressure with?papilledema?and proximal myopathy.
Sicherheitsprofil
Poison by intraperitoneal route. Moderately toxic by ingestion.Human systemic effects by ingestion: muscle weakness, paresthesia, and hepatitis. Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.
2-(2,2-Dicyclohexylethyl)piperidiniumhydrogenmaleat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
