Anti-CD28 antibody, Mouse monoclonal

Anti-CD28 antibody, Mouse monoclonal Struktur
CAS-Nr.
Englisch Name:
Anti-CD28 antibody, Mouse monoclonal
Synonyma:
Anti-CD28 antibody, Mouse monoclonal
CBNumber:
CB14669097
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Anti-CD28 antibody, Mouse monoclonal Eigenschaften

storage temp. 
2-8°C
Aggregatzustand
buffered aqueous solution

Sicherheit

Anti-CD28 antibody, Mouse monoclonal Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Monoclonal Anti-CD28 antibody produced in mouse is suitable for the following applications:
  • Flow cytometry at a dilution of 5μL using 1 × 106 cells
  • Immunocytochemistry
  • Immunohistochemistry (frozen sections)
The antibody has been used for development of an assay to identify small molecules antagonists of CD28/CD86 binding.

Allgemeine Beschreibung

CD28 (Cluster of differentiation 28) is a glycosylated membrane protein. The protein exists as a homodimer. CD28 is encoded by the gene mapped to human chromosome 2q33. The encoded protein is a co-stimulatory receptor expressed on naive T-cells. CD28 is characterized with a short cytoplasmic tail and two proline-rich motifs.

Biochem/physiol Actions

CD28 (Cluster of differentiation 28) is a protein expressed on T-cells that provide co-stimulatory signals required for T-cell activation, survival and differentiation into effector T cells. CD28 is also expressed on multiple myeloma (MM) cells and is a key mediator of MM survival and apoptotic resistance. CD28 pro-survival signaling is dependent upon downstream activation of phosphatidylinositol 3-kinase (PI3K)/AKT (RAC-alpha serine/threonine-protein kinase), inactivation of the transcription factor FoxO3a and decreased expression of the pro-apoptotic molecule BIM. CD28 plays an important role as a mediator of MM survival during stress and can be targeted to overcome chemotherapy resistance. Inflammatory CD28- T-cells are found to be accumulated in livers of patients with primary sclerosing cholangitis (PSC) and are localized around bile ducts. Autoantibodies against CD28 are found in patients with autoimmune and atopic diseases.

Anti-CD28 antibody, Mouse monoclonal Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Anti-CD28 antibody, Mouse monoclonal Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 1)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80

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