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(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat Produkt Beschreibung

Enalapril maleate  Struktur
76095-16-4
CAS-Nr.
76095-16-4
Bezeichnung:
(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat
Englisch Name:
Enalapril maleate
Synonyma:
BQL;Pres;Ednyt;Envas;Nuril;Xanef;MK-421;Enaloc;Enaril;Hytrol
CBNumber:
CB1467853
Summenformel:
C24H32N2O9
Molgewicht:
492.52
MOL-Datei:
76095-16-4.mol

(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat Eigenschaften

Schmelzpunkt:
143-144,5°C
Siedepunkt:
0°C
alpha 
D25 -42.2° (c = 1 in methanol)
Flammpunkt:
0°C
storage temp. 
-20°C Freezer
Löslichkeit
methanol: ≥50 mg/mL, clear, colorless to yellow
Aggregatzustand
powder
pka
pKa1 3.0; pKa2 (25°) 5.4
Farbe
white to off-white
Wasserlöslichkeit
Soluble in water, methanol, and ethanol.
maximale Wellenlänge (λmax)
208nm(MeOH)(lit.)
Merck 
14,3567
CAS Datenbank
76095-16-4(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi,Xn
R-Sätze: 36/37/38-62-63
S-Sätze: 22-24/25-36/37-26
RIDADR  3077
WGK Germany  2
RTECS-Nr. TW3666000
HS Code  29339900
Giftige Stoffe Daten 76095-16-4(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H361 Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Reproduktionstoxizität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P281 Vorgeschriebene persönliche Schutzausrüstung verwenden.

(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Enalapril maleate is the second angiotensin converting enzyme inhibitor to reach the marketplace. Like captopril, the first entry in this area, enalapril is useful in the treatment of hypertension and congestive heart failure. It has a longer effective half-life than captopril, allowing once or twice-daily dosing, and appears to have a somewhat lower incidence of side effects.

Chemische Eigenschaften

White to Off-White Crystalline Powder

Originator

Merck (USA)

Verwenden

sunscreen

Verwenden

An antihypertensive. An angiotensin-converting enzyme (ACE) inhibitor.

Definition

ChEBI: The maleic acid salt of enalapril. It contains one molecule of maleic acid for each molecule of enalapril. Following oral administration, the ethyl ester group of enalapril is hydrolysed to afford the corresponding carboxylic acid, enalaprilat, an angioten in-converting enzyme (ACE) inhibitor. Enalapril is thus a prodrug for enalaprilat (which, unlike enalapril, is not absorbed by mouth), and its maleate is used in the treatment of hypertension and heart failure, for reduction of proteinuria and renal diseas in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients.

Trademarks

RENITEN

Allgemeine Beschreibung

Enalapril maleate, 1-[N[(S)-1-carboxy-3-phenylpropyl]-L-alanyl]-L-proline 1 -ethyl estermaleate (Vasotec), is a long-acting ACE inhibitor. It requiresactivation by hydrolysis of its ethyl ester to form thediacid enalaprilat. Enalapril is devoid of the side effects ofrash and loss of taste seen with captopril. These side effectsare similar to those of the mercapto-containing drugpenicillamine. The absence of the thiol group in enalaprilmaleate may free it from these side effects. The half-life is11 hours.

Veterinary Drugs and Treatments

The principle use of enalapril/enalaprilat in veterinary medicine at present is as a vasodilator in the treatment of heart failure. Recent studies have demonstrated that enalapril, particularly when used in conjunction with furosemide, does improve the quality of life in dogs with heart failure. It is not clear, however, whether it has any significant effect on survival times. It may also be of benefit in treating the effects associated with valvular heart disease (mitral regurgitation) and left to right shunts. It is being explored as adjunctive treatment in chronic renal failure and protein losing nephropathies.
While ACE inhibitors are a mainstay for treating hypertension in humans, they have not been particularly useful in treating hypertension in dogs or cats.

(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 300)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21672 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 535 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30003 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 295 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58

76095-16-4((S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat)Verwandte Suche:


  • alapril Maleate
  • ENALAPRIL MALEATE, IMP. D (EP): ETHYL(2S)-2-[(3S,8AS)-3-METHYL-1,4-DIOXO-OCTAHYDROPYRROLO[1,2-ALPHA]PYRAZIN-2-YL]-4-PHENYLBUTANOATE MM(CRM STANDARD)
  • ENALAPRIL MALEATE, MM(CRM STANDARD)
  • ENALAPRIL MALEATE, EP STANDARD
  • ENALAPRIL MALEATE, USP STANDARD
  • ENALAPRIL MALEATE EPE
  • ENALAPRIL MALEATE EPE(CRM STANDARD)
  • ENALAPRIL MALEATE MM
  • ENALAPRIL MALEATE USP
  • ENALAPRIL MALEATE USP(CRM STANDARD)
  • EnalaprilMaleateBase
  • Enalapril Maleate Salt
  • L-Proline, N-(1S)-1-(ethoxycarbonyl)-3-phenylpropyl-L-alanyl-, (2Z)-2-butenedioate (1:1)
  • (s)-n-[1-(ethoxycarbonyl)-3-phenylpropyl]-ala-pro maleate salt
  • Acetensil
  • Alphrin
  • Analept
  • Benalipril
  • (s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-proline (z)-2-butenedioate salt
  • (S)-1-[N-[1-(ETHOXYCARBONXYL)-3-PHENYLPROPYL]-L-ALANYL]-L-PROLINE
  • [S]-1-[N-(1-[ETHOXYCARBONYL]-3-PHENYLPROPYL)-6-ALANYL]-L-PROLINE MALEATE
  • N-[[(S)-1-ETHOXYCARBONYL-3-PHENYLPROPYL]-L-ALANYL]-L-PROLINE MALEATE(1: 1)
  • MK-421
  • ENALAPRIL MALEATE
  • CARDIOVET
  • BITENSIL
  • AMPRACE
  • Enalapril malete
  • Enalapril maleate salt,(S)-N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro maleate salt
  • Enalapril Maleate (200 mg)
  • Enalapril Maleate (200 mg)J1C2670.992mg/mg(ai)
  • (S,S,S)-Enalapril Maleate
  • Enalapril Maleate (Vasotec)
  • Acapril
  • N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline (2Z)-2-Butenedioate
  • Enalapril Maleate API
  • Enalapril Maleate (EP)
  • Enalapril male
  • N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline,(2Z)-2-butenedioate (1:1)
  • (2S)-1-(2-((1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)pyrrolidine-2-carboxylic acid compound with maleic acid (1:1)
  • 1-(2-{[1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl)proline maleate
  • (S)-1-((S)-2-((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-ylamino)propanoyl)pyrrolidine-2-carboxylic acid compound with maleic acid (1:1)
  • Converten, Enapren, Enaril, Innovace, Naprilene, Olivin, Pres, Renitec, Reniten, Renivace,Vasotec,Xanef,MK-421
  • Enalapril maleate, 98%, an angiotensin converting enzyme inhibitor
  • 1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-prolin(s)-l-prolin(z)-2-bu
  • 1-[n-[1-(ethoxycarbonyl)-3-phenylpropyl]-l-alanyl]-l-prolin(s)-l-prolin(z)-2-but
  • mk421maleate
  • Enalapril Maleate USP24,25,EP2000
  • Enalapril maleate BP2000/USP25
  • ENALAPRIL MALEATE, IMP. I (EP): 1H-IMIDAZOLE MM(CRM STANDARD)
  • (s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-prolinemaleate(1:1
  • Biocronil
  • BQL
  • Controlvas
  • Converten
  • Convertin
  • Ednyt
  • Elfonal
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