ChemicalBook
Chinese english Germany Japanese Korea

4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-on Produkt Beschreibung

4-DiMethylaMino Antipyrine Struktur
58-15-1
CAS-Nr.
58-15-1
Bezeichnung:
4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-on
Englisch Name:
4-DiMethylaMino Antipyrine
Synonyma:
Febron;Dereuma;Dipirin;Dipyrin;Hyparon;Pirazon;Piridol;Amidozon;Amidofen;Dipyrine
CBNumber:
CB1476086
Summenformel:
C13H17N3O
Molgewicht:
231.29
MOL-Datei:
58-15-1.mol

4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-on Eigenschaften

Schmelzpunkt:
107-109 °C(lit.)
Siedepunkt:
373.38°C (rough estimate)
Dichte
1.0744 (rough estimate)
Brechungsindex
1.6140 (estimate)
storage temp. 
Refrigerator
pka
pKa 5.0 (Uncertain)
Aggregatzustand
Crystalline Powder, Crystals and/or Chunks
Farbe
Off-white to brownish
Wasserlöslichkeit
5.55 g/100 mL
Sensitive 
Air & Light Sensitive
Merck 
14,474
Stabilität:
Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive. Degrades under the action of mild oxidizing agents in the presence of moisture or water.
InChIKey
RMMXTBMQSGEXHJ-UHFFFAOYSA-N
CAS Datenbank
58-15-1(CAS DataBase Reference)
NIST chemische Informationen
Aminopyrine(58-15-1)
EPA chemische Informationen
Aminopyrine (58-15-1)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22-36/37/38-21/22
S-Sätze: 26-36-36/37/39
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS-Nr. CD2625000
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29331190
Giftige Stoffe Daten 58-15-1(Hazardous Substances Data)
Toxizität LD50 orally in rats: 1.7 g/kg (Hart)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P330 Mund ausspülen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-on Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R21/22:Gesundheitsschädlich bei Berührung mit der Haut und beim Verschlucken.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Chemische Eigenschaften

white crystalline powder

Verwenden

Antipyretic; analgesic.

Verwenden

Antipyretic;ACTH secretor

Verwenden

Oxidation by Fe(VI) has potential to remove N-nitrosodiumethylamine precursors, including 4-dimethylaminoantipyrine, from drinking water. 4-Dimethylaminoantipyrine is itself an effective scavenger of reactive nitrogen compounds nitric oxide and peroxynitrite, important in the inflammatory response.

Definition

ChEBI: A pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic proper ies.

Trademarks

Adexogan;Agevis;Algimicin anttitermico;Amidazopen;Amidozen;Anoixal;Antigripina;Areumal;Axiston;Balbion;Barsedan;Baukal suppositories;Bayer 1387 p;Bronchisan;Brufaneuseol;Butapyrine;Capsyka dr knapf;Capysal;Chinopyrin;Cibalgin;Ciclazon;Clinit;Coffan;Compral;Cusayth;Demolpas;Dentigoa;Depiral c;Dexa escopyrin;Dha 51;Dialpyrin;Digisab;Dimametten;Dimopyrin;Diprin;Dolo-attirin;Dolo-optineural;Dolorphen;Dolovosano;Donobin;Duerin;Dysmensan;Escopyrinus;Espasnatex;Eufibran;Euprogan;Febren;Febrosolvin;Fenodone;Fever;Flivalgin;Flumil;Framidone;Ftalazon;Funapon;Galenopyrin;Glucopirina;Glucopitina;Helvagit-f;Hemicraneal;Hisense-p;Influnal depot;Inst;Irgapyrine;Isoftal;Kalmine;Katareuma;Lagaflex;Latepyrine;Lauroanginol;Manslu;Medispanmin;Meloka;Neuro-demoplast;Nifedon;Nikartrone;Nostress;Optineural(analgesic);Optipax;Osadrine;Osmotipax;P.s.b.p.;Piracodid;Piradenil;Piradol;Pirasco;Piraseptolo.

Weltgesundheitsorganisation (WHO)

Aminophenazone, a pyrazolone derivative, has been used as an antiinflammatory and analgesic agent for over a century. Its use has been associated with cases of bone marrow depression and agranulocytosis and more recently it has been claimed to have a carcinogenic potential. Products containing aminophenazone have been formally withdrawn in many countries and marketing has been voluntarily suspended in others. Elsewhere, however, proprietary preparations containing this ingredient may remain available. (Reference: (WHODI) WHO Drug Information, 3, 9, 1977)

Allgemeine Beschreibung

Small colorless crystals or white crystalline powder. Aqueous solution slightly alkaline to litmus. pH (5% water solution) 7.5-9. Odorless. Slightly bitter taste.

Air & Water Reaktionen

Water soluble.

Reaktivität anzeigen

Aminophenazone is sensitive to exposure to light. Aminophenazone is readily attacked by mild oxidizing agents in the presence of water. Aminophenazone is incompatible with acacia, apomorphine, aspirin, chloral hydrate, iodine and tannic acid.

Brandgefahr

Flash point data for Aminophenazone are not available; however, Aminophenazone is probably combustible.

Biochem/physiol Actions

Antipyrine was found to be nonmutagenic when screened against Salmonella typhimurium tester strains TA100, TA98, TA97, TA102 and TA104.

Sicherheitsprofil

Human poison by unspecified route. Experimental poison by ingestion, subcutaneous, intramuscular,intravenous, and intraperitoneal routes. Moderately toxic by parenteral route. Experimental teratogenic and reproductive effects. Questionable carcinogen when mixed with NaNO2 (1:l). Mutation data reported. Can cause bone marrow depression resulting in leucopenia. Has been implicated in development of aplastic anemia. A tranquilizer. When heated to decomposition it emits toxic fumes of NOx.

läuterung methode

It crystallises from pet ether, sublimes between 80o and 90o, and forms metal complexes. [Beilstein 25 H 452, 25 III/IV 3555.]

4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-on Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 256)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
alice@crovellbio.com China 5941 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14344 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58

58-15-1(4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-on)Verwandte Suche:


  • 2-dihydro-4-(N.,N-dimethylamino-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
  • 4-Dimethylamino-2,3-dimethyl-1-phenyl pyrazol-1-one, 97%
  • 4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Aminopyrine
  • Amidozon
  • Aminofebrin
  • Aminopyrazolin
  • 4-(Dimethylamino)antipyrine, 98+%
  • 4-Dimethylaminoantipyrine,97%
  • 4-Dimethylaminoantipyrine,4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, Aminopyrine
  • 4-DiMethylaMino-1,5-diMethyl-2-phenyl-1-pyrazolone
  • 4-DiMethylaMino-1,5-diMethyl-2-phenyl-2-pyrazolone
  • MetaMizole IMpurity D
  • Cladomia anaurocraea
  • AMidopyrine/aMinopyrine
  • 4-DiMethylaMinoantipyrine, 97% 5GR
  • 200-365-8
  • 4-DIMETHYLAMINOANTIPYRINE, REACTIVE
  • AMINOPYRENE
  • ANTIPYRENE,4-(DIMETHYLAMINO)-
  • PIRAMIDONE
  • 4-(DIMETHYLAMINO)PHENAZONE
  • 4-(DIMETHYLAMINO)-1,5-DIMETHYL-2-PHENYL-3-PYRAZOLONE
  • 4-DIMETHYLAMINOANTIPYRINE
  • 4-DIMETHYLAMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE
  • 4-(DIMETHYLAMINO)-2,3-DIMETHYL-1-PHENYL-5-PYRAZOLONE
  • 4-DIMETHYLAMINO-2,3-DIMETHYL-1-PHENYLPYRAZOL-5-ONE
  • AMIDOPYRINE
  • AMINOPYRINE
  • AMINOPHENAZONE
  • PYRAMIDON
  • (Dimethylamino)phenazone
  • 1,5-Dimethyl-2-phenyl-4-dimethylamino-3-pyrazolone
  • 1,5-Dimethyl-4-dimethylamino-2-phenyl-3-pyrazolone
  • 1-Phenyl-2,3-dimethyl-4-(dimethylamino)-5-pyrazolone
  • 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one
  • Pyramidon, Amidozon, Aminophenazon, Aminopyrine
  • Aminophenazone Solution, 1000ppm
  • 4-DIMETHYLAMINO-2,3-DIMETHYL-1-PHENYLPYRAZOL-5-ONE BP2000
  • 4-(dimethylamino)-1,5-dimethyl-2-phenylpyrazol-3-one
  • 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazolone-5
  • 2,3-Dimethyl-4-dimethylamino-1-phenyl-5-pyrazolone
  • 3H-Pyrazol-3-one, 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-
  • 3-keto-1,5-Dimethyl-4-dimethylamino-2-phenyl-2,3-dihydropyrazole
  • 3-Pyrazolin-5-one, 4-(dimethylamino)-2,3-dimethyl-1-phenyl-
  • 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-on
  • 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-one
  • 4-(Dimethylamino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
  • 4-(dimethylamino)-2,3-dimethyl-1-phenyl-3-pyrazolin-5-on
  • 4-(dimethylamino)-antipyrin
  • 4-Dimethylamino-1-phenyl-2,3-dimethylpyrazolone
  • 4-Dimethylaminoantipyrine;Aminopyrine
  • Aminopyrinum
  • Amidopyrinum
  • 4-DIMETHYLAMINOANTIPYRINE FREE BASE
  • Amidazofen
  • Amidazophen
  • Amidazophene
  • Amidofebrin
Copyright 2019 © ChemicalBook. All rights reserved