PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem

PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A cell-permeable thiazolidinedione compound that is shown to inhibit the enzymatic activity of PTP1B, SHP-1, YOP, TC-PTP, and YPTP1 (IC₅₀ = 5, 5.8, 6, 16, and 18 μM, respectively), but not that of LAR even at concentrations as high as 100 μM. Also reported to activate cellular PPAR with an comparable potency seen with troglitazone (Cat. No. 648469). The combined effect of PTP1B inhibition and PPAR activation most likely accounts for the compound′s in vivo antiobesity and antihypoglycemic activity when supplemented directly into the daily high fat diet of C57BL/6j jms Slc male mice (2 mg/g food, ~143 mg/kg animal weight or 4.8 mg/animal).

PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80

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• PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem
• 2,4-Thiazolidinedione, 5-[[2-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-5-bromophenyl]methylene]-
• 1229246-07-4
• C19H10BrF6NO3S