InSolution GM 6001 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs
in vitro [K
i = 0.4 nM for skin fibroblast collagenase (MMP-1); K
i = 0.5 nM for gelatinase A (MMP-2); K
i = 27 nM for stromelysin (MMP-3); K
i = 0.1 nM for neutrophil collagenase (MMP-8); and K
i = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-α
in vivo and
in vitro and abrogates endotoxin-induced lethality in mice.
Biochem/physiol Actions
Cell permeable: yes
InSolution GM 6001 - Calbiochem Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
