NFAT Inhibitor, Cell-Permeable - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Use at 1 μM for preventing the activation and proliferation of T cells
Allgemeine Beschreibung
A cell-permeable version of NFAT Inhibitor (Cat. No. 480402) that is modified at the C-terminus with an 11-arginine transduction domain and a 3-glycine linker sequence. Prevents the activation and proliferation of T cells both
in vitro (~43% at 1 μM using mixed lymphocyte cultures) and
in vivo (10 mg/kg using C3H/HeN mice). Show to be effective in providing immunosuppression in a murine islet xenograft model. Unlike Cyclosporin A (Cat. No. 239835) and FK-506, 11R-VIVIT does not cause side effects outside the immune system as a result of calcineurin (Cat. No. 539568) inhibition, therefore serves as a less toxic alternative for animal studies. The functional half-life of 11R-VIVIT has been estimated to be ~30 h in Jurkat cells.
Biochem/physiol Actions
Primary TargetNFAT
NFAT Inhibitor, Cell-Permeable - Calbiochem Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
