S6K1 Inhibitor, PF-4708671 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A cell-permeable piperazinyl-pyrimidine compound that acts as an inhibitor against S6K1 (K
i = 20 nM; IC
50 = 160 nM) and MSK1 (IC
50 = 950 nM) kinase activity, exhibiting little or much reduced potency against 85 other protein and lipid kinases (IC
50 = 4.7, 9.2, 65 μM, respectively, against RSK1, RSK2, and S6K2; ≤27% inhibition of the rest at 1 μM). Shown to selectively inhibit IGF1- and PMA-stimulated S6K1 substrates phosphorylation in HEK-293 cells in a dose-dependent manner (up to 10 μM)
in vitro and alleviate heart remodeling and functional damage in a MI (myocardial infarction) model in mice
in vivo (75/mg/kg/daily i.p.).
S6K1 Inhibitor, PF-4708671 - Calbiochem Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
