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Dihydromyricetin Produkt Beschreibung

Dihydromyricetin Struktur
27200-12-0
CAS-Nr.
27200-12-0
Englisch Name:
Dihydromyricetin
Synonyma:
ampeloptin;AMPELOPSIN;3,3',4',5,5;,(2r-trans)-;Ampelopsin(AMP);DIHYDROMYRICETIN;ampelopsin(flavanol);DIHYDROMYRICETIN(RG);(+)-Dihydromyricetin;Two hydrogenMyricetin
CBNumber:
CB1670507
Summenformel:
C15H12O8
Molgewicht:
320.25
MOL-Datei:
27200-12-0.mol

Dihydromyricetin Eigenschaften

storage temp. 
-20°C
Löslichkeit
DMSO: ≥5mg/mL (warmed)
Aggregatzustand
powder
Siedepunkt:
780.7±60.0 °C(Predicted)
Dichte
1.808±0.06 g/cm3(Predicted)
Schmelzpunkt:
239-241 °C
pka
7.38±0.60(Predicted)
Farbe
white to beige
InChIKey
KJXSIXMJHKAJOD-LSDHHAIUSA-N
CAS Datenbank
27200-12-0

Sicherheit

S-Sätze: 24/25
WGK Germany  3
HS Code  29329990

Dihydromyricetin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Dihydromyricetin (DHM), also called ampelopsin, is the major flavonoid in Ampelopsis plants, primarily in the species grossedentata. It is also found in some other plant species, such as the Japanese raisin tree, Hovenia dulcis. These plants have been used as part of traditional Asian medicine, due to their reported anti-inflammatory, antioxidant, and anti-cancer properties, which have more recently been attributed to their high DHM content. DHM is sold as a supplement and is commonly marketed as a treatment for hangovers due to its ability to reduce blood alcohol levels and projected hepatoprotective properties. In preclinical animal models, DHM shows a variety of beneficial anti-aging properties, by reducing inflammation, oxidative stress, lipidemia, as well as regulating energy metabolism and promoting autophagy. These effects are primarily derived from its ability to activate sirtuins. However, the magnitude of the benefits seen in preclinical studies has not yet translated to the effects seen in clinical trials, likely due to the poor stability and bioavailability of currently available DHM preparations.

Definition

ChEBI: An optically active form of dihydromyricetin having (2R,3R)-configuration.

Clinical Use

Dihydromyricetin (DHM) is a natural antioxidant, It is a flavonoid isolated from Ampelopsis grossedentata (Hand.-Mazz.) W.T. Wang (family Vitaceae), an edible plant used in traditional Chinese medicine (Li et al., 2017). The original herb has effects of detoxification, anti-inflammatory and analgesic, commonly used as a dietary supplement. DHM is now demonstrated to impede atherosclerotic process by regulating endothelial dysfunction(Yang D. et al.,2018),and exert anti-aging effect against neurodegenerative diseases (Kou et al.,2016).It inhibits miR-21 expression and then improves endothelial dysfunction induced by TNF- , accompanied by suppression of abnormal expression of eNOS, DDAH1, NO, and ADMA, as well as improvement of tube formation and migration. Furthermore, miR-21 blockade can produce similar effects with DHM treatment; while miR-21 overexpression abolishes the above protection. Additionally,improvement of endothelial dysfunction can be reversed by a non-specific NOs inhibitor, indicating DHM ameliorates vascular endothelial function and inhibits atherosclerosis by targeting miR-21-mediated DDAH1/ADMA/NO signal pathway(Yang D.et al., 2018).

Dihydromyricetin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dihydromyricetin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 303)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Aktin Chemicals, Inc.
028-85159085
86-28-85159085 Ex:604 info@aktinchem.com CHINA 1026 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2858 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58

27200-12-0()Verwandte Suche:


  • 2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on
  • 3,3’,4’,5,5’,7-hexahydroxy-2,3-dihydroflavanonol
  • 3,3’,4’,5,5’,7-hexahydroxy-flavanon
  • DihydroMyricetin, froM Myrica rubra
  • Two hydrogenMyricetin
  • (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
  • Dihydromyricetin (+)-Dihydromyricetin
  • Ampelopsin (2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one
  • Ampelopsin(AMP)
  • Dihydromyricetin (DHM)
  • Dihydromyricetin, 98%, from Myrica rubra
  • 3,3',4',5,5
  • Nano Liposomal Dihydromyricetin
  • 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
  • Dihydromyricetin 27200-12-0
  • 4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-, (2R,3R)-
  • ampelopsin(flavanol)
  • ampeloptin
  • DIHYDROMYRICETIN(RG)
  • 3,3’,4’,5,5’,7-hexahydroxyflavanone
  • (2R)-2,3-Dihydro-3β,5,7-trihydroxy-2α-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
  • (2R)-2α-(3,4,5-Trihydroxyphenyl)-3β,5,7-trihydroxy-2,3-dihydro-4H-1-benzopyran-4-one
  • DihydroMyricetin(AMpeloptin)
  • DihydroMyricetin, AMpelopsin
  • (+)-Dihydromyricetin
  • (2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one
  • AMPELOPSIN
  • DIHYDROMYRICETIN
  • (2r-trans)-2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benz
  • ,(2r-trans)-
  • aMpeloptin,(2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroMan-4-one
  • Dihydromyricetin 25%-98%
  • Dihydromyricetin,HPLC≥98%
  • Dihydromyricetin fandachem
  • 27200-12-0
  • C21H12O8
  • natural product
  • Inhibitors
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • chemical reagent
  • pharmaceutical intermediate
  • Flavanones
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