HUMAN TGF-BETA3

HUMAN TGF-BETA3 Struktur
CAS-Nr.
Englisch Name:
HUMAN TGF-BETA3
Synonyma:
TGF-BETA3;HUMAN TGF-B3;TGF-β3 active;HUMAN TGF-BETA3;TGF-BETA3, HUMAN;TGF-beta 3-E. coli human;RECOMBINANT HUMAN TGF-B3;TRANSFORMING GROWTH FACTOR-BETA3;TRANSFORMING GROWTH FACTOR-BETA3, HUMAN;HUMAN TRANSFORMING GROWTH FACTOR BETA 3
CBNumber:
CB1702226
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

HUMAN TGF-BETA3 Eigenschaften

storage temp. 
-20°C
Aggregatzustand
powder
Farbe
white

Sicherheit

WGK Germany  3

HUMAN TGF-BETA3 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

TGF-β3 (transforming growth factor β 3) human has been used in the media for the chondrogenic differentiation of the stromal cells. It has been used in the culture medium to allow attachment of primary human dermal fibroblasts to the scaffolds.

Allgemeine Beschreibung

The gene TGF-β3 (transforming growth factor β 3) is mapped to human chromosome 14q24.3. The three mammalian isoforms of TGF-β, TGF-β1, β2, β3 elicit similar biological responses. TGF-β proteins are made as precursor molecules which are cut to generate a mature carboxy-terminal region of 110-140 amino acids. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. Recombinant TGF-β3 is a 25.0kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

Biochem/physiol Actions

The three mammalian isoforms of TGF-β (transforming growth factor β), TGF-β1, β2, β3, are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. TGF-β3 is the predominant TGF-β in the testis and controls the blood-testis barrier activity. Polymorphisms in this gene might be associated with male infertility. Heterozygous mutation in the gene at position Arg300 might be associated with increased TGF-β signaling, leading to a disorder with phenotypic overlap with Marfan syndrome and Loeys-Dietz syndrome. TGF-β3 is involved in the mesenchymal stem cells (MSCs)-mediated inhibition of fibroblast proliferation and decreases skin fibrosis.

HUMAN TGF-BETA3 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


HUMAN TGF-BETA3 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 38)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
3bsc@sina.com China 15848 69
United States Biological --
sales@advtechind.com United States 6106 58

  • HUMAN TRANSFORMING GROWTH FACTOR BETA 3
  • HUMAN TGF-BETA3
  • HUMAN TGF-B3
  • TGF-BETA3
  • TGF-BETA3, HUMAN
  • RECOMBINANT HUMAN TGF-B3
  • TRANSFORMING GROWTH FACTOR-BETA3
  • TRANSFORMING GROWTH FACTOR-BETA3, HUMAN
  • TRANSFORMING GROWTH FACTOR-BETA3, HUMAN, RECOMBINANT
  • TGF-beta 3-E. coli human
  • TGF-β3 active
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