Gummi arabicum Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
Chemische Eigenschaften
white to yellow-white powder
Verwenden
As mucilage, excipient for tablets, size, emulsifier, thickener, also in candy, other foods; as colloidal stabilizer. In the manufacture of spray-dried "fixed" flavorsstable, powdered flavors used in packaged dry-mix products (puddings, desserts, cake mixes) where flavor stability and long shelf life are important.
Definition
The dried, water-soluble exudate
from the stems of Acacia senegal or related species.
Vorbereitung Methode
Acacia is the dried gummy exudate obtained from the stems and
branches of Acacia senegal (Linné ) Willdenow or other related
species of Acacia (Fam. Leguminosae) that grow mainly in the
Sudan and Senegal regions of Africa.
The bark of the tree is incised and the exudate allowed to dry on
the bark. The dried exudate is then collected, processed to remove
bark, sand, and other particulate matter, and graded. Various acacia
grades differing in particle size and other physical properties are
thus obtained. A spray-dried powder is also commercially available.
Allgemeine Beschreibung
White powder.
Air & Water Reaktionen
Water soluble. Aqueous solution is acid to litmus.
Reaktivität anzeigen
Arabic gum reacts with strong oxidizing agents. Arabic gum precipitates out of solution or jellies upon addition of solutions of ferric salts, borax, basic lead acetate, alcohol, sodium silicate, gelatin or ammoniated tincture of guaiac.
Health Hazard
Exposures to gum arabica dust produce a weak allergen reaction. Prolonged periods of
dust inhalation may cause allergic respiratory reaction, headache, coughing, dizziness,
dyspnea, respiratory symptoms such as asthma, watery nose and eyes, cough, wheezing,
nausea, vomiting, dyspnea, and urticaria. Hives, eczema, and swelling may also occur.
Ingestion and inhalation of gum acacia is considered non-toxic, but sensitive individuals
may develop symptoms of mild toxicity.
Brandgefahr
Flash point data for Arabic gum are not available; however, Arabic gum is probably combustible.
Pharmazeutische Anwendungen
Acacia is mainly used in oral and topical pharmaceutical formulations
as a suspending and emulsifying agent, often in combination
with tragacanth. It is also used in the preparation of pastilles and
lozenges, and as a tablet binder, although if used incautiously it can
produce tablets with a prolonged disintegration time. Acacia has
also been evaluated as a bioadhesive; and has been used in novel
tablet formulations,and modified release tablets.
Acacia is also used in cosmetics, confectionery, food products,
and spray-dried flavors.
Sicherheitsprofil
Very low toxicity by ingestion.Inhalation or ingestion has produced hives, eczema, andangiodema. Experimental reproductive effects. A severeeye irritant. A weak allergen. Mutation data reported.Combustible. When heated to decomposition it emitsacrid
Sicherheit(Safety)
Acacia is used in cosmetics, foods, and oral and topical
pharmaceutical formulations. Although it is generally regarded as
an essentially nontoxic material, there have been a limited number
of reports of hypersensitivity to acacia after inhalation or
ingestion.Severe anaphylactic reactions have occurred following
the parenteral administration of acacia and it is now no longer
used for this purpose.
The WHO has not set an acceptable daily intake for acacia as a
food additive because the levels necessary to achieve a desired effect
were not considered to represent a hazard to health.
LD
50 (hamster, oral): >18 g/kg
LD
50 (mouse, oral): >16 g/kg
LD
50 (rabbit, oral): 8.0 g/kg
LD
50 (rat, oral): >16 g/kg
Lager
Aqueous solutions are subject to bacterial or enzymatic degradation
but may be preserved by initially boiling the solution for a short
time to inactivate any enzymes present; microwave irradiation can
also be used. Aqueous solutions may also be preserved by the
addition of an antimicrobial preservative such as 0.1% w/v benzoic
acid, 0.1% w/v sodium benzoate, or a mixture of 0.17% w/v
methylparaben and 0.03% propylparaben. Powdered acacia should
be stored in an airtight container in a cool, dry place.
Inkompatibilitäten
amidopyrine, apomorphine, cresol, ethanol (95%), ferric salts,
morphine, phenol, physostigmine, tannins, thymol, and vanillin.
An oxidizing enzyme present in acacia may affect preparations
containing easily oxidizable substances. However, the enzyme may
be inactivated by heating at 100℃ for a short time.
Many salts reduce the viscosity of aqueous acacia solutions,
while trivalent salts may initiate coagulation. Aqueous solutions
carry a negative charge and will form coacervates with gelatin and
other substances. In the preparation of emulsions, solutions of
acacia are incompatible with soaps.
Regulatory Status
GRAS listed. Accepted for use in Europe as a food additive.
Included in the FDA Inactive Ingredients Database (oral preparations
and buccal or sublingual tablets). Included in the Canadian
List of Acceptable Non-medicinal Ingredients. Included in nonparenteral
medicines licensed in the UK.
Gummi arabicum Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
