Natriumfluoracetat Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSER FESTSTOFF IN VERSCHIEDENEN FORMEN.
CHEMISCHE GEFAHREN
Zersetzung beim Erhitzen oder Verbrennen unter Bildung giftiger Rauche mit Fluorwasserstoff.
ARBEITSPLATZGRENZWERTE
TLV: 0,05 mg/m?(als TWA); Hautresorption; (ACGIH 2005).
MAK: 0,05 mg/m?(Einatembare Fraktion); Spitzenbegrenzung: überschreitungsfaktor II(4); Hautresorption; Schwangerschaft: Gruppe C; (DFG 2006).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch schnell erreicht werden.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Möglich sind Auswirkungen auf das Herzkreislaufsystem und das Zentralnervensystem mit nachfolgenden Herzfunktionsstörungen und Atemversagen. Exposition kann zum Tod führen.
LECKAGE
Gefahrenbereich verlassen! Fachmann zu Rate ziehen! Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.
R-Sätze Betriebsanweisung:
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R50:Sehr giftig für Wasserorganismen.
S-Sätze Betriebsanweisung:
S13:Von Nahrungsmitteln, Getränken und Futtermitteln fernhalten.
S22:Staub nicht einatmen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Chemische Eigenschaften
Sodium fluoroacetate is a fluffy, colorless, odorless, hygroscopic solid (sometimes dyed black).
Verwenden
Sodium fluoroacetate is used for rodent control in restricted
environments and for the control of the brushtail possum and other wild
mammals in some countries.
Allgemeine Beschreibung
A fine, white, odorless, powdered solid. Toxic by ingestion, inhalation and skin absorption. Used as a rodenticide.
Air & Water Reaktionen
Water soluble.
Reaktivität anzeigen
Salts, basic, such as SODIUM FLUOROACETATE, are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Hazard
Toxic by ingestion, inhalation, and skin
absorption. For use by trained operators only, use
has been restricted. Cardiac impairment, central
nervous system impairment, and nausea.
Health Hazard
SODIUM FLUOROACETATE is super toxic. The probable oral lethal dose in humans is less than 5 mg/kg, or a taste (less than 7 drops) for a 150-lb. person.
Brandgefahr
When heated to decomposition, SODIUM FLUOROACETATE emits highly toxic fumes of sodium oxide and fluorides. Avoid decomposing heat.
Landwirtschaftliche Anwendung
Insecticide, Rodenticide, Wildlife control: A U.S. EPA restricted Use Pesticide (RUP). Not listed for use in EU countries. It is seldom used as an insecticide. Sodium fluoroacetate is primarily used around sewers, ships and warehouses, and in agriculture and by state agricultural departments as bait for rodents and large predators, to control rats, mice, squirrels, prairie dogs, coyotes, rabbits and otherpests. It is seldom used as an insecticide. It is very toxic to birds, domestic animals and wildlife either by consuming the bait or eating poisoned carcasses. It is sometimes used in 1% solutions which are injected into collars which are strapped to the necks of sheep, goats and other livestock that predators are attracted to. Coyotes that puncture the collars are likely to be fatally poisoned by the sodium fluoroacetate as a result.
Handelsname
AI3-08434®; FLUORAKIL® 3; FRATOL®; FURATOL®; RATBANE 1080®; TENEIGHTY®; TL 869®; YASOKNOCK®
Sicherheitsprofil
A deadly human poison by ingestion. Experimental poison by ingestion, skin contact, intraperitoneal, subcutaneous, and intravenous routes. A very highly toxic water-soluble salt used mainly as an immediate-action rodenticide. It is absorbed rapidly by the gastrointestinal tract but slowly by the skin unless the skin is abraded or cut. It operates by blocking the Krebs cycle by formation of fluorocitric acid, which inhbits aconitase. It has an effect on either the cardiovascular or nervous system, or both, in all species and, in some species, the skeletal muscles. Humans have mixed responses, with the cardiac feature predominating. By a duect action on the heart, contractile power is lost, which leads to declining blood pressure. Ventricular premature contractions and arrhythmias are seen in all species, including humans. The central nervous system is directly attacked by sodtum fluoroacetate. In humans, the action on the central nervous system produces epileptiform convulsive seizures followed by severe depression. The dangerous dose for humans is 0.5-2 mg/kg. Other species vary considerably in their response to hs material, with primates and birds being the most resistant and carnivora and rodents being the most susceptible. Most domestic animals show a susceptibility fahng between the two extremes indtcated above. Experimental reproductive effects. When heated to decomposition it emits highly toxic fumes of NazO and F-.
mögliche Exposition
A potential danger to those involved in the manufacture, formulation, and application of this highly toxic, immediate-action rodenticide.
Carcinogenicity
In developmental studies in rats
0.75mg/kg/day administered by gavage on
days 6–17 of gestation caused significant reductions
in maternal and fetal body weight gains,
but no external fetal abnormalities were noted.
Environmental Fate
Ingestion, inhalation, and dermal exposures are all possible,
but ingestion is the major route of exposure. Sodium fluoroacetate
is rapidly absorbed by the gastrointestinal tract and
by the lungs. There is evidence that leaching and metabolism
are the major routes of dissipation. Sodium fluoroacetate
which has not undergone degradation is considered mobile by
the EPA and has a high risk for movement into the soil and the
ground water. Once adsorbed in soil, sodium fluoroacetate can
be degraded by halidohydrolase in many microbial and fungal
species. The ‘half-life’ of sodium fluoroacetate in soil is
dependent on temperature, weather, and initial amount of
chemical and decomposition of the host animal. There have
been no reports that sodium fluoroacetate can leach into water
and reach levels exceeding that which would be deemed toxic.
Stoffwechselwegen
Sodium fluoroacetate is toxic to all mammals, especially to dogs (LD50
0.1 mg kg
-1) and therefore its use is very restricted. An exception is the
aerial application of baits for the control of the brushtail possum in
New Zealand and of other wild mammals in Australia. Such use is controversial
and has been the impetus for some environmental fate studies
(Eason et al., 1993) and secondary toxicity studies.
The role of fluoroacetate in interfering with citrate metabolism is now
classical biochemical toxicology (see below).
Versand/Shipping
UN2629 Sodium fluorosilicate, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
läuterung methode
It is a free-flowing white HIGHLY TOXIC powder which is purified by dissolving it in ca 4 parts of H2O and the pH is checked. If it is alkaline, add a few drops of FCH2CO2H to make the solution just acidic. Evaporate (fumehood) on a steam bath until crystals start to separate, cool and filter the solid off. More solid can be obtained by adding EtOH to the filtrate. Dry it at 100o in vacuum. The p-nitrobenzyl ester crystallises from EtOH with m 76o. POISONOUS. The free acid interferes with the citric acid cycle. [Saunders & Stacey J Chem Soc 1778 1948, Beilstein 2 IV 446.]
Inkompatibilitäten
Incompatible with alkaline metals and carbon disulfide. Avoid decomposing heat.
Waste disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. This compound is unstable at temperatures above 110°C and decomposes @ 200°C. Thus, careful incineration has been suggested as a disposal procedure. According to their procedure, the produce should be mixed with large amounts of vermiculite, sodium bicarbonate, and sand-soda ash. Slaked lime should also be added to the mixture. Two incineration procedures for this mixture are suggested. The better of these procedures is to burn the mixture in a closed incinerator equipped with an afterburner and an alkali scrubber. The other procedure suggests that the mixture be covered with scrap wood and paper in an open incinerator. (The incinerator should be lighted by means of an excelsior train).
Natriumfluoracetat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
