LUMIRACOXIB
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- CAS-Nr.
- 220991-20-8
- Englisch Name:
- LUMIRACOXIB
- Synonyma:
- Prexige;COX 189;CGS 35189;Lumaricoxib;Unii-V91T9204hu;Prexige, Lumiracoxib;Xanthine Impurity 30;LuMiracoxib (COX-189);Lumiracoxib (CGS 35189;Lumiracoxib, COX-189, Prexige
- CBNumber:
- CB21006324
- Summenformel:
- C15H13ClFNO2
- Molgewicht:
- 293.72
- MOL-Datei:
- 220991-20-8.mol
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LUMIRACOXIB Eigenschaften
- Schmelzpunkt:
- 139-141°C
- Siedepunkt:
- 395.7±42.0 °C(Predicted)
- Dichte
- 1.363±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- ≥29.4 mg/mL in DMSO; insoluble in H2O; ≥27.15 mg/mL in EtOH with ultrasonic
- Aggregatzustand
- solid
- pka
- 4.18±0.10(Predicted)
- CAS Datenbank
- 220991-20-8
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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LUMIRACOXIB Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
As a second-generation, selective cyclooxygenase (COX-2) inhibitor, lumiracoxib
is devoid of the gastrointestinal issues that plague other non-selective, nonsteroidal,
anti-inflammatory drugs (NSAIDs) that crossover to COX-1. As an inhibitor
of the inducible COX-2 that is up-regulated in pathological processes of
pain and inflammation, lumiracoxib blocks the conversion of arachidonic acid to
prostaglandins, the mediators of the pathological effects. It’s mode of binding to
COX-2 has been found to differ from the other selective COX-2 inhibitors; the
carboxylic acid forms hydrogen bonds with Tyr-385 and Ser-530 in the catalytic site
rather than seeking interactions within the larger hydrophobic side pocket. Since lumiracoxib is mainly metabolized by CYP2C9, a study evaluating
the co-administration of lumiracoxib with fluconazole, a potent inhibitor of
CYP2C9, was conducted, and it concluded that there was no need for lumiracoxib
dose adjustment, since changes in the systemic exposure were not significant. No
serious adverse effects were reported, but in the small number of cases where
treatment was discontinued, Gastro intestinal (GI) and musculoskeletal complaints
were common.
Chemische Eigenschaften
Pale Yellow Solid
Verwenden
Lumiracoxib is a selective cyclooxygenase-2-(COX-2) inhibitor and an anti-inflammatory agent (1,2,3,4).
Definition
ChEBI: An amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthrit
s, but was withdrawn due to concersns of hepatotoxicity.
LUMIRACOXIB Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
LUMIRACOXIB Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 129)Lieferanten
220991-20-8()Verwandte Suche:
- 2-[2-[(2-chloro-6-fluoro-phenyl)amino]-5-methyl-phenyl]acetic acid
- 2-[(2-Chloro-6-fluorophenyl)amino]-5-methylbenzeneacetic Acid
- CGS 35189
- COX 189
- Prexige
- Lumaricoxib
- Benzeneacetic acid, 2-((2-chloro-6-fluorophenyl)amino)-5-methyl-
- Unii-V91T9204hu
- Lumiracoxib, COX-189, Prexige
- LuMiracoxib (COX-189)
- 2-(5-((2-chloro-6-fluorophenyl)amino)-2-methylphenyl)acetic acid
- 2-[2-(2-chloro-6-fluoroanilino)-5-methylphenyl]acetic acid
- Lumiracoxib (CGS 35189
- 2-[2-(2-Chloro-6-fluorophenylamino)-5-methylphenyl]acetic ac...
- Prexige, Lumiracoxib
- Cyclooxygenase,Inhibitor,bone cancer,osteoarthritis,inflammatory,COX189,inhibit,hyperalgesic,COX 189,Lumiracoxib,COX,Metabolic Syndrome
- Xanthine Impurity 30
- 220991-20-8
- C15H13ClFNO2
- Inhibitors
- PREXIGE
- Aromatics Compounds
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
