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Vatalanib Dihydrochloride

Vatalanib Dihydrochloride Struktur
212141-51-0
CAS-Nr.
212141-51-0
Englisch Name:
Vatalanib Dihydrochloride
Synonyma:
PTK/ZK;CS-465;CGP-79787;ZK-222584;CGP-79787D;CGP79787) 2HCl;Vatalinib 2HCl;PTK787 dihydrochloride;Vatalanib 2HCl (PTK787);Vatalanib (PTK787) 2HCl
CBNumber:
CB21176854
Summenformel:
C20H17Cl3N4
Molgewicht:
419.74
MOL-Datei:
212141-51-0.mol
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Vatalanib Dihydrochloride Eigenschaften

Schmelzpunkt:
268-2700C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
Löslichkeit
Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml)
Aggregatzustand
solid
Farbe
White or off-white
Stabilität:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS Datenbank
212141-51-0
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
R-Sätze: 36/37/38
S-Sätze: 24/25
HS Code  29333990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P271 Nur im Freien oder in gut belüfteten Räumen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Vatalanib Dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively. It less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on a large panel of additional kinases. Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.

Chemische Eigenschaften

White to Off-White Crystalline Powder

Verwenden

Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Antineoplastic.

Vatalanib Dihydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Vatalanib Dihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 128)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29914 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873
 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 47465 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-519-519-85557386
marketing1@neostarunited.com China 8349 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 29321 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321
 info@finetechnology-ind.com China 9702 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739
 info@dycnchem.com CHINA 52867 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58

212141-51-0()Verwandte Suche:

Lysinhydrochlorid Pyridiniumchlorid Triethylammoniumchlorid Glucosaminhydrochlorid Ethylendiammoniumdichlorid Vatalanib base Gemcitabine hydrochloride Diphenylammoniumchlorid Methoxyammoniumchlorid Dihydrochloride
  • CGP-79787 Dihydrochlorid
  • N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Dihydrochloride
  • Vatalanib Dihydrochloride
  • CGP-79787 Dihydrochloride
  • Vatalanib 2hcl((ZK-222584,PTK 787)
  • Vatalanib dihydrochloride (PTK787)
  • CGP-79787
  • CGP-79787D
  • PTK/ZK
  • ZK-222584
  • CGP-79787, PTK 787, ZK222584
  • N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride
  • ZK 222584 (cpg-79787) 2HCl
  • Vatalanib 2HCl (PTK787)
  • Vatalanib (PTK787) 2HCl
  • Vatalanib (hydrochloride)
  • Vatalanib dihydrochloride(2HCL)
  • Vatalanib (PTK787) diHydrochloride
  • CS-465
  • ZK-222584 dihydrochloride
  • CGP-797870 dihydrochloride
  • PTK787 dihydrochloride
  • Vatalanib Dihydrochloride USP/EP/BP
  • 1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, hydrochloride (1:2)
  • CGP79787) 2HCl
  • Vatalinib 2HCl
  • 212141-51-0
  • C20H17Cl3N4
  • C20H15ClN42HCl
  • C20H15Cl2N42HCl
  • C20H15ClN42ClH
  • Heterocycles
  • Tyrosine Kinase Inhibitors
  • Antineoplastic
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Inhibitors
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