ABT 263 Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Pale Yellow Solid
Verwenden
A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate.
Mechanism of action
ABT‐263 exerts its senolytic activity in senescent tumor cells by inhibiting BCL‐XL's interaction with BAX. ABT‐263 is a BH3 mimetic that inhibits anti‐apoptotic BCL‐2 family proteins by impeding their ability to bind pro‐apoptotic proteins, such as BAK and BAX. BCL‐2 and BCL‐XL are the primary targets of ABT‐263 in cancer cells.
ABT 263 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte