Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

160844-75-7

CAS-Nr.: 160844-75-7

Englisch Name:: Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate

Synonyma:: 2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-Thiazolecarboxylic acid ethyl ester;Febuxostat Ethyl Ester;Febuxostat-7;FEBUXOSTAT INT N-1;Non-Bust Impurity 23;Febuxostat Impurities3;ethyl ester of febuxostat;Febuxostat Ethyl Ester Impurity;ethyl 2-(3-cyano-4-isobutoxyphenyl);2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Me

CBNumber:: CB22129451

Summenformel:: C18H20N2O3S

Molgewicht:: 344.43

MOL-Datei:: 160844-75-7.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 393

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Eigenschaften

Schmelzpunkt:: 176 °C

Siedepunkt:: 497.1±55.0 °C(Predicted)

Dichte: 1.22

storage temp.: Sealed in dry,Room Temperature

Löslichkeit: DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)

Aggregatzustand: Solid

pka: 1.02±0.10(Predicted)

Farbe: White to Off-White

InChI: InChI=1S/C18H20N2O3S/c1-5-22-18(21)16-12(4)20-17(24-16)13-6-7-15(14(8-13)9-19)23-10-11(2)3/h6-8,11H,5,10H2,1-4H3

InChIKey: OGAZOYHQFBSRMC-UHFFFAOYSA-N

SMILES: S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(OCC(C)C)C(C#N)=C1

CAS Datenbank: 160844-75-7(CAS DataBase Reference)

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

HS Code	2934.10.2000

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P

Sicherheit

P264	Nach Gebrauch gründlich waschen.
P264	Nach Gebrauch gründlich waschen.
P280	Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352	BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P321	Besondere Behandlung
P332+P313	Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P362	Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen.

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White crystalline powder

Verwenden

Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

Synthese

CarboxylatePotassium carbonate (300 g, 2.17 mol) and isobutyl bromide (142.7 g, 1.041 mol) were added to a solution of ethyl-2-(3-cyano-4-hydroxyphenyl)-4-methyl-5-thiazole carboxylate (100 g, 0.347 mol) in dimethylformamide (300 mL), and the reaction mixture was heated at a temperature of about 75°C for about 8 hours. After completion of the reaction, the reaction mixture was cooled to about 40°C, and water was added. The reaction mixture was further cooled to about 0°C and stirred for about 1 hour. The solid thus obtained was filtered, washed with water, and dried to give Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate. (Yield: 11 lg, 92.9%)

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

5-iodo-2-isobutoxybenzonitrile ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate 5-bromo-2-isobutoxy benzonitirle 3-Cyano-4-(2-methylpropoxy)benzenecarbothioamide (3-cyano-4-isobutoxyphenyl)boronic acid Febuxostat Impurity 6 ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Ethyl 4-methyl-5-thiazoleactate Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 5-Bromo-2-fluorobenzonitrile 1-Brom-2-methylpropan

Downstream Produkte

Febuxostat

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 393)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.	+86-18616643091 +86-18616643091	info@rochipharma.com	China	246	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12457	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55

160844-75-7()Verwandte Suche:

5-Nitrobenzol-1,2-dicarbonitril Thiazol-5-carbonsure 4-Methylthiazol

5-Thiazolecarboxylicacid, 2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-, ethyl ester
2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
Ethyl> 2-(3-cyano-4-isobutoxyphenyl)-4-Methyl-5-th
5-carboxylato-2-[3-cyano-4-(2-Methylpropoxy)phenyl]-1-ethyl-4-Methyl-1H-1$l^{4},3-thiazol-1-yl
ethyl ester of febuxostat
2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Me
Febuxostat Ethyl Ester Impurity
Febuxostat Impurity 15/Febuxostat Ethyl Ester/Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazol
Febuxostat-7
2[3-Cyano-4-(2-methyl propoxy)phenyl]4-methyl-5-thiazole carboxylic acid ethyl ester (CPT)
ethyl 2-(3-cyano-4-isobutoxyphenyl)
Non-Bust Impurity 23
2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester
FEBUXOSTAT INT N-1
2-[3-CYANO-4-(2-METHYLPROPOXY)PHENYL]-4-METHYL-5-THIAZOLECARBOXYLIC ACID ETHYL
Febuxostat intermediates，Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4- methyl-5-thiazolecarboxylate
2-(4-isobutoxyphenyl)-3-carboxylate)4-methyl-1,3- thiazole-5- carboxylate acid( Febuxostat dicarboxylic acid impurity)
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarbo...
Febuxostat Impurities3
2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl esterQ: What is 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl ester Q: What is the CAS Number of 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl ester Q: What is the storage condition of 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl ester
Febuxostat Ethyl Ester
2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-Thiazolecarboxylic acid ethyl ester
Ethyl 2-(3- cyano -4- isobutyloxyphenyl) -4- methylthiazole -5- carboxylate
Ethyl 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylate
Ethyl 2-(3-cyno-4-isobutoxyphenyl)-4-methyl-5- thiazolecarboxylate
2-(4-ISOBUTOXYPHENYL)-3-CARBOXYLATE)4-METHYL-1,3- THIAZOLE-5-
Febuxostat Ethyl Ester Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5- carboxylate
160844-75-7
161797-01-2
Febuxostat Intermediates
Febuxostat intermediate