Dichloressigsäure, Verbindung mitN-(1-Methylethyl)-2-propanamin(1:1)

Diisopropylammonium dichloroacetate Struktur
660-27-5
CAS-Nr.
660-27-5
Bezeichnung:
Dichloressigsäure, Verbindung mitN-(1-Methylethyl)-2-propanamin(1:1)
Englisch Name:
Diisopropylammonium dichloroacetate
Synonyma:
N-isopropylpropan-2-amine;Diisopropylammonium;Dedyl;Dapocel;β-Anoxin;Oxypangam;N-propan-2-ylpropan-2-amine;diisopropylaMini dichlorocacetas;diisopropylammonium dichloroacetate;Diisopropylaminedichloroacetate,95%
CBNumber:
CB22130466
Summenformel:
C8H17Cl2NO2
Molgewicht:
230.13208
MOL-Datei:
660-27-5.mol

Dichloressigsäure, Verbindung mitN-(1-Methylethyl)-2-propanamin(1:1) Eigenschaften

Schmelzpunkt:
119-121°
RTECS-Nr.
AG6475000
storage temp. 
Sealed in dry,Room Temperature
Löslichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Crystalline Powder
Farbe
White
Merck 
14,3197
Stabilität:
Hygroscopic
InChI
InChI=1S/C6H15N.C2H2Cl2O2/c1-5(2)7-6(3)4;3-1(4)2(5)6/h5-7H,1-4H3;1H,(H,5,6)
InChIKey
ILKBHIBYKSHTKQ-UHFFFAOYSA-N
SMILES
C(O)(=O)C(Cl)Cl.CC(NC(C)C)C
CAS Datenbank
660-27-5
EPA chemische Informationen
Acetic acid, dichloro-, compd. with N-(1-methylethyl)-2-propanamine (1:1) (660-27-5)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
TSCA  Yes
HS Code  2921199990
Toxizität LD50 orally in mice: 1700 mg/kg (Kraushaar)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Dichloressigsäure, Verbindung mitN-(1-Methylethyl)-2-propanamin(1:1) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Diisopropylammonium dichloroacetate is a hepatoprotective drug that improves the energy metabolism of hepatocytes, promotes the regeneration of injured hepatocytes, increases the rate of tissue cell respiration and oxygen respiration, and reduces the accumulation of fat in the liver. It is mainly used clinically for the treatment of fatty liver, intrahepatic cholestasis, and general liver dysfunction. It is also used in the treatment of acute and chronic hepatitis, hepatomegaly, and early cirrhosis.

Chemische Eigenschaften

White or off-white loose mass or powder, slightly bitter, easily soluble in water, ethanol or chloroform, slightly soluble in ether.

History

In the 1950s, the compound diisopropylammonium dichloroacetate (DIPA) was used in the synthesis of methylated derivatives of a purportedly naturally occurring B vitamin (pangamic acid; dgluconodimethylaminoacetate). Anecdotal clinical reports appeared claimingefficacy in various metabolic and cardiovascular disorders from pharmaceuticalmixtures of pangamic acid and DIPA. In 1970,DCA was identified as themetabolically active moiety of DIPA(Stacpoole & Felts,1970) and it has beenused thereafter almost exclusively as the sodium salt.

Verwenden

Diisopropylammonium dichloroacetate (DIPA) is known to produce a significant and prolonged hypoglycemic effect in alloxan-diabetic but not in normal rats.
Diisopropylamine 2,2-Dichloroacetate is used in the treatment of antituberculosis drugs-induced liver injury.

Definition

ChEBI: Diisopropylamine dichloroacetate is an organohalogen compound and a carboxylic acid.

Synthese

Diisopropylammonium dichloroacetate is prepared by the reaction of dichloro-acetic acid and diisopropylamine. The steps are as follows:
1 volume of acetone is mixed with 1.5 volumes of cyclohexane to obtain a mixed solvent; Add 1 mol of diisopropylamine (101.19g, C6H15N, Mr=101.19) into 150ml of mixed solvent, stir evenly, and heat the liquid material to 50°C; slowly add 1mol of dichloroacetic acid (128.94g, C2H2Cl2O2, Mr=128.94) dropwise to the liquid material obtained in step (at a speed of about 10g/min) under heat preservation and stirring conditions,After the feeding is complete, keep warm and continue to stir for 3 hours, then naturally cool to 4-8°C, and then stand at this temperature for 10 hours; Filter the material obtained in step, separate the mother liquor, collect white crystals, and dry at 70° C. to obtain 216.8 g of the diisopropylamine dichloroacetate (C8H17Cl2NO2, Mr=230.13), with a molar yield of 94.2%.
Diisopropylammonium dichloroacetate synthesis

Dichloressigsäure, Verbindung mitN-(1-Methylethyl)-2-propanamin(1:1) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dichloressigsäure, Verbindung mitN-(1-Methylethyl)-2-propanamin(1:1) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 249)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
shandong perfect biotechnology co.ltd
+86-53169958659; +8618596095638
sales@sdperfect.com China 294 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
sales@frappschem.com China 885 50
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806
sales@capotchem.com China 29797 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21700 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714
fandachem@gmail.com China 9354 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Jinan Shengqi pharmaceutical Co,Ltd
86+18663751872
christine@shengqipharm.com CHINA 491 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58

660-27-5(Dichloressigsäure, Verbindung mitN-(1-Methylethyl)-2-propanamin(1:1))Verwandte Suche:


  • Dapocel
  • Dedyl
  • Oxypangam
  • β-Anoxin
  • N-propan-2-ylpropan-2-amine
  • diisopropylammonium dichloroacetate
  • diisopropylaMini dichlorocacetas
  • bis(propan-2-yl)aMino 2,2-dichloroacetate
  • Diisopropylamine 2,2-dichloroacetate
  • Diisopropylammonium dichloroacetate USP/EP/BP
  • Diisopropylamine dichloroacetate 97%
  • Diisopropylaminedichloroacetate,95%
  • Diisopropylammonium
  • N-isopropylpropan-2-amine
  • 660-27-5
  • Liver Disease Series
Copyright 2019 © ChemicalBook. All rights reserved