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Bisacodyl Produkt Beschreibung

Bisacodyl Struktur
603-50-9
CAS-Nr.
603-50-9
Bezeichnung:
Bisacodyl
Englisch Name:
Bisacodyl
Synonyma:
laco;Bicol;LA96A;neolax;ivilax;Laxans;laxine;zetrax;nigalax;Pyrilax
CBNumber:
CB2233693
Summenformel:
C22H19NO4
Molgewicht:
361.39
MOL-Datei:
603-50-9.mol

Bisacodyl Eigenschaften

Schmelzpunkt:
138°C
Siedepunkt:
493.21°C (rough estimate)
Dichte
1.2545 (rough estimate)
Brechungsindex
1.5614 (estimate)
storage temp. 
2-8°C
Löslichkeit
Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent). It dissolves in dilute mineral acids.
pka
4.69±0.10(Predicted)
Aggregatzustand
neat
Wasserlöslichkeit
Soluble in alcohol (slightly), ether (slightly), chloroform, and acetone. Insoluble in water.
maximale Wellenlänge (λmax)
220nm(MeOH)(lit.)
Merck 
14,1242
Stabilität:
Stable. Incompatible with strong oxidizing agents.
InChIKey
KHOITXIGCFIULA-UHFFFAOYSA-N
CAS Datenbank
603-50-9(CAS DataBase Reference)
NIST chemische Informationen
Bisacodyl(603-50-9)
EPA chemische Informationen
Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester) (603-50-9)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 22-36/37/38
S-Sätze: 26-36
WGK Germany  3
RTECS-Nr. SM8750000
TSCA  Yes
HS Code  2933399090
Giftige Stoffe Daten 603-50-9(Hazardous Substances Data)
Toxizität LD50 orally in rats: >3 g/kg (Schmidt)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Bisacodyl Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

Crystalline Solid

Originator

Dulcolax,Boehringer Ingelheim,US,1958

Verwenden

Stimulant laxative.

Verwenden

Cathartic.

Manufacturing Process

Preparation of (4,4'-Dihydroxy-Diphenyl)-(Pyridyl-2)-Methane 70.0 grams of α-pyridine aldehyde are fed portionwise with stirring and cooling to a mixture of 200 grams of phenol and 100 cc of concentrated sulfuric acid. The reaction mixture is allowed to stand for a while with repeated stirring, whereby it becomes syrupy, neutralized with sodium carbonate, dissolved in methanol and filtered. The filtrate is introduced into a large quantity of water and the resulting precipitate is recrystallized from a methanol/water mixture. Colorless crystals are obtained of MP 254°C. When using zinc chloride or tin tetrachloride and warming to a temperature of about 50°C, a corresponding result is obtained.
Preparation of Bisacodyl: 5 grams of (4,4'-dihydroxy-diphenyl)-(pyridyl-2)- methane are heated with 5 grams of anhydrous sodium acetate and 20 cc of acetic anhydride for three hours over a boiling water bath. The cooled reaction mixture is poured into water, whereby after a while a colorless substance precipitates, which is filtered off with suction, washed with water and recrystallized from aqueous ethanol. Colorless bright crystals, MP 138°C are obtained.

Trademarks

Correctol Tablets, Caplets (Schering-Plough HealthCare); Dulcolax (Boehringer Ingelheim); Evac-Q-Tabs (Savage); Feen-a- Mint Tablets (Schering-Plough HealthCare); Modane (Savage); SK-Bisacodyl (SmithKline Beecham); Theralax (SmithKline Beecham).

Therapeutic Function

Laxative

Veterinary Drugs and Treatments

Bisacodyl oral and rectal products are used as stimulant cathartics in dogs and cats.

Bisacodyl Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Bisacodyl Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 270)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21711 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22617 55
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3048 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Hebei bin yun import and export co., LTD
+8618034552304 +86 19930599843
86-0311-83975816 cindy@hbbinyun.com CHINA 575 58
Jinan Chenghui-Shuangda Chemical Co.,Ltd
+86-531-58897082
+86-531-58897093 ericqiao@jnchsd.com CHINA 158 58
Jinan Shengqi pharmaceutical Co,Ltd
86+18663751872
christine@shengqipharm.com CHINA 478 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28230 58
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 sales@zhonglanindustry.com CHINA 4895 58

603-50-9(Bisacodyl)Verwandte Suche:


  • 2-(4,4’-diacetoxydiphenylmethyl)pyridine
  • 2-(4,4'-Diacetoxydiphenylmethyl)pyridine
  • 4,4'-(2-Pyridylmethylene)diphenol diacetate
  • 4,4'-(2-Pyridylmethylene)diphenol diacetate (ester)
  • 4,4’-(2-pyridinylmethylene)bis-phenodiacetate(ester)
  • 4,4’-(2-pyridylmethylene)di-phenodiacetate(ester)
  • 4,4’-(2-pyridylmethylene)-diphenolacetate
  • 4,4’-(2-Pyridylmethylene)-diphenolace-tate
  • 4,4’-(2-pyridylmethylene)diphenoldiacetate
  • neolax
  • nigalax
  • Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate
  • Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester)
  • Phenol, 4,4'-(2-pyridylmethylene)di-, diacetate
  • phenol,4,4’-(2-pyridinylmethylene)bis-,diacetate(ester)
  • Pyrilax
  • sanvacual
  • Sk-bisacodyl
  • stadalax
  • telemin
  • Theralax
  • BISACODYL
  • AURORA KA-6302
  • GENTLAX (PURDUE FREDERICK)
  • EX-LAX ULTRA (NOVARTIS)
  • LAXADIN (TEVA)
  • LABOTEST-BB LT00134695
  • DULCOLAN (BOEHRINGER, ING)
  • dulcolax
  • DULCOLAX (BOEHRINGER, ING)
  • DUROLAX (BOEHRINGER, ING)
  • CONTALAX (3M PHARMA)
  • CORRECTOL (SCHERING-PLOUGH)
  • STADALAX (STADA)
  • PERILAX (FERRING)
  • PYRILAX (BERLIN-CHEMIE)
  • 4,4'-DIACETOXYDIPHENYLPYRIDYL-2-METHANE
  • [4-[(4-acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate
  • 4,4'-(2-pyridylmethylene)bisphenol diacetate
  • (4,4’-diacetoxydiphenyl)(2-pyridyl)methane
  • (4,4'-Diacetoxydiphenyl)(2-pyridyl)methane
  • 4,4’-diacetoxydiphenylpyrid-2-ylmethane
  • 4,4'-Diacetoxydiphenylpyrid-2-ylmethane
  • 4-[[4-(Acetyloxy)phenyl](2-pyridinyl)methyl]phenyl acetate
  • Bicol
  • bicosacodyl
  • Bis(p-acetoxyphenyl)-2-pyridylmethane
  • brocalax
  • broxalax
  • deficol
  • Di-(4-acetoxyphenyl)-2-pyridylmethane
  • Di-(p-acetoxyphenyl)-2-pyridylmethane
  • Dulcolan
  • durolax
  • endokolat
  • eulaxan
  • fenilaxan
  • godalax
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