Bisacodyl Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Crystalline Solid
Originator
Dulcolax,Boehringer
Ingelheim,US,1958
Verwenden
Stimulant laxative.
Verwenden
Cathartic.
Manufacturing Process
Preparation of (4,4'-Dihydroxy-Diphenyl)-(Pyridyl-2)-Methane
70.0 grams of α-pyridine aldehyde are fed portionwise with stirring and
cooling to a mixture of 200 grams of phenol and 100 cc of concentrated
sulfuric acid. The reaction mixture is allowed to stand for a while with
repeated stirring, whereby it becomes syrupy, neutralized with sodium
carbonate, dissolved in methanol and filtered. The filtrate is introduced into a
large quantity of water and the resulting precipitate is recrystallized from a
methanol/water mixture. Colorless crystals are obtained of MP 254°C. When
using zinc chloride or tin tetrachloride and warming to a temperature of about
50°C, a corresponding result is obtained.
Preparation of Bisacodyl: 5 grams of (4,4'-dihydroxy-diphenyl)-(pyridyl-2)-
methane are heated with 5 grams of anhydrous sodium acetate and 20 cc of
acetic anhydride for three hours over a boiling water bath. The cooled reaction
mixture is poured into water, whereby after a while a colorless substance
precipitates, which is filtered off with suction, washed with water and
recrystallized from aqueous ethanol. Colorless bright crystals, MP 138°C are
obtained.
Trademarks
Correctol
Tablets, Caplets (Schering-Plough HealthCare); Dulcolax
(Boehringer Ingelheim); Evac-Q-Tabs (Savage); Feen-a-
Mint Tablets (Schering-Plough HealthCare); Modane
(Savage); SK-Bisacodyl (SmithKline Beecham); Theralax
(SmithKline Beecham).
Therapeutic Function
Laxative
Veterinary Drugs and Treatments
Bisacodyl oral and rectal products are used as stimulant cathartics
in dogs and cats.
Bisacodyl Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
