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Molsidomin Produkt Beschreibung

Molsidomine Struktur
25717-80-0
CAS-Nr.
25717-80-0
Bezeichnung:
Molsidomin
Englisch Name:
Molsidomine
Synonyma:
SIN-10;Coruno;morial;CAS 276;CORVATON;corvasal;Corraton;MOTAZOMIN;SydnopharM;molsidolat
CBNumber:
CB2234645
Summenformel:
C9H14N4O4
Molgewicht:
242.23
MOL-Datei:
25717-80-0.mol

Molsidomin Eigenschaften

Schmelzpunkt:
140-141°C
Siedepunkt:
385.05°C (rough estimate)
Dichte
1.3186 (rough estimate)
Brechungsindex
1.6300 (estimate)
storage temp. 
Inert atmosphere,2-8°C
Löslichkeit
Sparingly soluble in water, soluble in anhydrous ethanol and in methylene chloride.
Aggregatzustand
neat
pka
pK (100°) 3.0 ± 0.1
maximale Wellenlänge (λmax)
317nm(MeOH)(lit.)
Merck 
14,6234
CAS Datenbank
25717-80-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22
S-Sätze: 36
WGK Germany  3
RTECS-Nr. WU7677400
HS Code  29349990
Toxizität LD50 in male, female mice, male, female rats (mg/kg): 780, 750, 1380, 1350 s.c.; 860, 800, 830, 760 i.v.; 700, 760, 1250, 1250 i.p.; 830, 840, 1050, 1200 orally (Nakaguchi)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit

Molsidomin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.

S-Sätze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

White to Off-White Solid

Originator

Corvasal,Hoechst

Verwenden

Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitric oxide donor.

Verwenden

Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitr ic oxide donor.

Manufacturing Process

1.6 parts by volume of ethyl chloroformate is stirred dropwise into a suspension of 1.0 part by weight of 3-morpholinosydnonimine hydrochloride in 5 parts by volume of pyridine, and the mixture is agitated for a while to allow reaction to take place. Pyridine is removed from the reaction mixture by evaporation, and the residue is dissolved in a small amount of water and extracted with chloroform several times. The extract is dehydrated by adding anhydrous magnesium sulfate and subjected to filtration. Chloroform is removed from the filtrate by distillation, crude crystals being obtained. Recrystallization of the crude crystals from toluene gives 0.6 part by weight of 3-morpholino-N-carboethoxysydnonimine having a melting point of 140°- 141°C. Yield 51%.

Trademarks

Corvaton (Hoechst-Roussel).

Therapeutic Function

Coronary vasodilator

Molsidomin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Molsidomin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 154)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3284 55
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58
career henan chemical co
15093356674 0371-55982848
0086-371-86658258 factory@coreychem.com CHINA 29863 58
Shaanxi Dideu Medichem Co. Ltd
15319487004
029-88380327 1015@dideu.com CHINA 3994 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58

25717-80-0(Molsidomin)Verwandte Suche:


  • ethyl (3-morpholin-4-yl-1-oxa-2-aza-3-azoniacyclopenta-2,4-dien-5-yl)aminoformate
  • CORVATON
  • N-Carboxy-3-morpholino-syndone imine ethyl ester
  • corvasal
  • SIN-10
  • n-carboxy-3-morpholinosynonimine ethyl ester
  • N-(ETHOXYCARBONYL)-3-(4-MORPHOLINO)SYDNONE IMINE
  • N-[ETHOXYCARBONYL]-3-[4-MORPHOLINYL]SYDNONE IMINE
  • MOTAZOMIN
  • MORSIDOMINE
  • MORSYDOMINE
  • MOLSIDOMINE
  • 5-[(Ethoxycarbonyl)aMino]-3-(4-Morpholinyl)-1,2,3-oxadiazoliuM Inner Salt
  • CAS 276
  • Corraton
  • Coruno
  • N-(Ethoxycarbonyl)-3-Morpholinosydnone iMine
  • SIN 10 (pharMaceutical)
  • SydnopharM
  • Molsidomine, 98%, Guanylate cyclase activator
  • N-(Ethoxycarbonyl)-3-(4-morpholino)sydnone imine, SIN-10
  • 1-Ethoxy-N-(3-morpholin-4-yl-1-oxa-2-aza-3-azoniacyclopenta-2,4-dien-5-yl)methanimidate
  • 5-Ethoxycarbonyl-3-morpholinosydnonimine
  • N-(Ethoxycarbonyl)-3-(4-morpholino)syndone imine
  • N-Ethoxycarbonyl-3-morphalinosydnomine
  • (1E)-1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate
  • molsidolat
  • morial
  • n-(ethoxycarbonyl)-3-(4-morpholinyl)-sydnoneimin
  • n-carboxy-3-morpholino-sydnoneiminethylester
  • n-carboxy-3-morpholinosydnonimineethylester
  • n-ethoxycarbonyl-3-morpholinosydnonimine
  • Molsidomine>
  • Molsidomine CRS
  • Molsidomine USP/EP/BP
  • 25717-80-0
  • C9H14N4O4
  • Nitric Oxide Metabolism
  • NO Donors
  • Cell Signaling Enzymes
  • Biochemicals and Reagents
  • Application Index
  • BioChemical
  • Enzymes, Inhibitors, and Substrates
  • Nitric Oxide
  • API
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